Influence of Glucagon on the Ischemic Liver in the Pig

Fredlund, P; Kallum, Bengt; Tibblin, S

doi:10.1001/archsurg.1972.04180100060015

Cited by 14 publications

(2 citation statements)

References 19 publications

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“…The method has been used extensively in our laboratory and can, therefore, be carried out rapidly and with a minimum of trauma. The replicability has been found to be good [6,7],…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Glucocorticoid Treatment on the Release of Acid Hydrolases from the Dearterialized Pig Liver

Fredlund¹,

Kallum²,

Vang³

1974

Eur Surg Res

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In vitro glucocorticoids are known to exert a membrane stabilizing effect on the cell membrane and to intracellular organelles. Treatment with these drugs has, therefore, been suggested for protection of the hypoxic liver during various procedures. With the use of the hepatic dearterialization in the pig as an experimental model for hepatic ischemia the plasma activity of the acid hydrolases glucosidase ?-galactosidase, and SGOT were studied after pre treatment with glucocorticoids. In control pigs dearterialization caused a typical pattern of plasma enzyme increase. Treatment with glucocorticoids before the hepatic dearterialization did not diminish the plasma enzyme reactions. The steroid-treated animals showed a significantly higher activity of all the investigated enzymes. Hepatic histopathology and the tissue activity of the liver enzymes were not clearly modified by the steroid treatment. Thus, in this type of hepatic ischemia treatment with glucocorticoids does not seem to protect the hypoxic liver. Possibly it might even be detrimental as judged from the ezyme reactions.

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“…The method has been used extensively in our laboratory and can, therefore, be carried out rapidly and with a minimum of trauma. The replicability has been found to be good [6,7],…”

Section: Discussionmentioning

confidence: 99%

“…The liver was dearterialized in the same way in all animals as described in pre vious communications [6,7]. Through an upper midline abdominal incision all the hepatic membraneous fixations were divided.…”

Section: Operative Proceduresmentioning

confidence: 99%

The Effect of Glucocorticoid Treatment on the Release of Acid Hydrolases from the Dearterialized Pig Liver

Fredlund¹,

Kallum²,

Vang³

1974

Eur Surg Res

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Ruptured Intrahepatic Aneurysm

Erskine¹

1973

Arch Surg

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Hepatic artery ligation and postoperative chemotherapy for hepatic metastases: Clinical and pathophysiological results

Sparks¹,

Mosher²,

Hallauer³

et al. 1975

Cancer

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Nineteen patients underwent hepatic artery ligation for metastatic cancer of the liver. Metastases were from colon cancer in 13 and from other primary cancers in 6. Postoperative chemotherapy was given to 15 by the systemic route, and to 1 by infusion into the ligated hepatic artery. Sixteen patients survived the procedure. In these patients, the mean survival of those with metastases from colon cancer was 2 7 f (5-72) weeks, and from other cancer 50+ (8-23) weeks. Among the patients evaluated, 57% had symptomatic improvement, 43% showed improvement in the liver scan, and 33% had a decrease in liver size. Our experience suggests that hepatic artery ligation can offer temporary but significant palliation in carefully selected patients.Cancer 35:1074-1082, 1975.

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Influence of Glucagon on the Ischemic Liver in the Pig

Cited by 14 publications

References 19 publications

The Effect of Glucocorticoid Treatment on the Release of Acid Hydrolases from the Dearterialized Pig Liver

The Effect of Glucocorticoid Treatment on the Release of Acid Hydrolases from the Dearterialized Pig Liver

Ruptured Intrahepatic Aneurysm

Hepatic artery ligation and postoperative chemotherapy for hepatic metastases: Clinical and pathophysiological results

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