Influence of glycemic control on pulmonary function and heart rate in response to exercise in subjects with type 2 diabetes mellitus

Brassard, Patrice; Ferland, Annie; Bogaty, Peter; Desmeules, Marc; Jobin, Jean; Poirier, Paul

doi:10.1016/j.metabol.2006.06.025

Cited by 23 publications

(22 citation statements)

References 39 publications

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“…In these studies, poor glycemic control seemed to have a stronger detrimental effect on chronotropic heart response during sub-maximal exercise, and on cardiovascular response to exercise, than on pulmonary response [93]. Nevertheless, the histopathological changes in diabetic lung parenchyma, interstitium, and vasculature may be responsible for a small functional reserve of the lung which, generally sub-clinical, could become evident in situations of increased functional request such as during physical exercise.…”

Section: Cardiopulmonary Exercise Testmentioning

confidence: 92%

The Diabetic Lung - A New Target Organ?

Pitocco

Fuso²,

Conte³

et al. 2012

Rev Diabet Stud

146

112

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■ AbstractSeveral abnormalities of the respiratory function have been reported in patients with type 1 and type 2 diabetes. These abnormalities concern lung volume, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Many hypotheses have emerged, and characteristic histological changes have been described in the "diabetic lung", which could explain this abnormal respiratory function. Given the specific abnormalities in diabetic patients, the lung could thus be considered as a target organ in diabetes. Although the practical implications of these functional changes are mild, the presence of an associated acute or chronic pulmonary and/or cardiac disease could determine severe respiratory derangements in diabetic patients. Another clinical consequence of the pulmonary involvement in diabetes is the accelerated decline in respiratory function. The rate of decline in respiratory function in diabetics has been found to be two-to-three times faster than in normal non-smoking subjects, as reported in longitudinal studies. This finding, together with the presence of anatomical and biological changes similar to those described in the aging lung, indicates that the "diabetic lung" could even be considered a model of accelerated aging. This review describes and analyses the current insight into the relationship of diabetes and lung disease, and suggests intensifying research into the lung as a possible target organ in diabetes.

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Section: Cardiopulmonary Exercise Testmentioning

confidence: 92%

The Diabetic Lung - A New Target Organ?

Pitocco

Fuso²,

Conte³

et al. 2012

Rev Diabet Stud

146

112

View full text Add to dashboard Cite

show abstract

“…During prolonged exercise, the decrement in plasma insulin levels further stimulates lipolysis and allows plasma free-fatty acids to provide the major substrate for energy [69,70]. The function of carnitine in energy metabolism is impaired in diabetes and is also associated with increased lipolysis and the mobilization of free-fatty acids [71].…”

Section: Metabolic Hormonal and Autonomic Modulation Of Exercise In mentioning

confidence: 99%

“…Acute hyperglycemia affects BRS and/or ANS function, whereas chronic hyperglycemia and elevated catecholamine levels decrease adrenergic response. Moreover, chronic hyperglycemia leads to alterations in lung structure affecting pulmonary ventilation in response to exercise, also via impaired chemoreflex and/or ergoreflex activity [70,71].…”

Section: Physiology and Exercise Capacity In Diabetesmentioning

confidence: 99%

Exercise improves cardiac autonomic function in obesity and diabetes

Voulgari¹,

Pagoni²,

Vinik

et al. 2013

Metabolism

Self Cite

109

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“…A subset showed excessively high tidal volumes during exercise resembling changes after vagotomy. The ventilatory response during submaximal exercise 6 and acute isocapneic hypoxia 7 was blunted in type 2 diabetes. Patients with diabetes demonstrate diminished ability to perceive inspiratory resistive loads.…”

Section: Respiratory Autonomic Neuropathymentioning

confidence: 90%

Lung Function Changes Related to Diabetes Mellitus

Hsia

Raskin

2007

Diabetes Technology & Therapeutics

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Diabetic microangiopathy targets the lung as it does other organs. Even though respiratory dysfunction in most patients with diabetes is subclinical and rarely the presenting complaint, there are several reasons why pulmonary assessment is important: (1) Pulmonary function testing noninvasively quantifies physiological reserves in a large microvascular bed that is not clinically devastated by diabetes. (2) Subclinical loss of pulmonary reserves becomes overtly debilitating under conditions of stress, such as with aging, chronic hypoxia due to lung disease or high altitude exposure, or volume overload secondary to cardiac and renal failure. (3) Unlike myocardial or skeletal muscle function, pulmonary indices are largely independent of physical fitness. (4) Interpretation of pulmonary function indices is not complicated by secondary sequelae of diabetic end-organ failure or prior therapy. Lung function could provide useful measures of the progression of systemic microangiopathy. (5) Chronic use of inhaled insulin may affect long-term pulmonary function, while preexisting pulmonary dysfunction may alter the absorption and bioavailability of inhaled insulin. This review will discuss the changes in lung function observed in diabetes, their underlying mechanisms, and their physiological and clinical implications.

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Influence of glycemic control on pulmonary function and heart rate in response to exercise in subjects with type 2 diabetes mellitus

Cited by 23 publications

References 39 publications

The Diabetic Lung - A New Target Organ?

The Diabetic Lung - A New Target Organ?

Exercise improves cardiac autonomic function in obesity and diabetes

Lung Function Changes Related to Diabetes Mellitus

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