Influence of gold nanoparticles on wound healing treatment in rat model: Photobiomodulation therapy

Lau, PikSuan; Bidin, Noriah; Islam, Shumaila; Shukri, Wan Norsyuhada Binti Wan Mohd; Zakaria, Nurlaily; Musa, Nurfatin; Krishnan, Ganesan

doi:10.1002/lsm.22614

Cited by 80 publications

(39 citation statements)

References 59 publications

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“…Wound healing is a natural process that repairs and regenerates damaged tissues, for example, in the skin (15), lung (16), or intestine (17). Numerous therapies have been developed to accelerate this process, involving, for example, pharmaceutics, stem cells, electrical stimulation, negative pressure, light, or radiation (15, 18–21).…”

Section: Wound Healingmentioning

confidence: 99%

“…Numerous therapies have been developed to accelerate this process, involving, for example, pharmaceutics, stem cells, electrical stimulation, negative pressure, light, or radiation (15, 18–21). Furthermore, NPs, especially those with antimicrobial properties, are considered as valuable tools in accelerating the wound-healing process (22).…”

Section: Wound Healingmentioning

confidence: 99%

“…Gold (Au) NPs were successful in acceleration of wound healing in combination with photobiomodulation therapy in rats (15) or in combination with the antioxidants epigallocatechin gallate (EGCG) and α-lipoic acid (ALA) in mice (30). The observed decrease of CD68 expression and increase of SOD1 expression around the wound area suggest that anti-inflammatory as well as antioxidative effects of the Au NP/EGCG/ALA mixture play a role in increased wound-healing efficiency (30).…”

Section: Wound Healingmentioning

confidence: 99%

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Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

et al. 2017

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The type 2 immune response is an adaptive immune program involved in defense against parasites, detoxification, and wound healing, but is predominantly known for its pathophysiological effects, manifesting as allergic disease. Engineered nanoparticles (NPs) are non-self entities that, to our knowledge, do not stimulate detrimental type 2 responses directly, but have the potential to modulate ongoing reactions in various ways, including the delivery of substances aiming at providing a therapeutic benefit. We review, here, the state of knowledge concerning the interaction of NPs with type 2 immune responses and highlight their potential as a multifunctional platform for therapeutic intervention.

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Section: Wound Healingmentioning

confidence: 99%

Section: Wound Healingmentioning

confidence: 99%

Section: Wound Healingmentioning

confidence: 99%

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Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

et al. 2017

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“…[13] In fact, few previous studies have reported the wound healing activity and antimicrobial property of large sized AuNPs (3-100 nm). [14][15][16][17] These AuNPs facilitated healing of infectious wound by several proposed mechanisms including (a) by altering the membrane potential of bacterial cells, resulting in the depletion of ATP, eventually disrupting the metabolism and death of bacterial cells, [18] (b) through the generation of reactive oxygen species (ROS), [19] and (c) by regulating anti-inflammatory cytokines and supporting angiogenesis. [20][21][22] Furthermore, the combination of AuNPs with polymers resulted in substantial increase in the wound healing activity.…”

Section: Introductionmentioning

confidence: 99%

Ultrasmall Gold Nanocluster Based Antibacterial Nanoaggregates for Infectious Wound Healing

et al. 2019

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Wound infections are a growing challenge and significantly delay the healing process. To overcome this challenge, nanotechnology‐inspired treatments have recently emerged as promising alternatives to conventional drugs and antibiotics. Here, we introduce a new type of antimicrobial nanoaggregate that integrates the intrinsic properties of ultra‐small gold nanoclusters (AuNCs) with a biocompatible antimicrobial polymer, namely, chitosan (CS). The synergetic combination created from the AuNCs and CS in the nanoaggregates resulted in superior antimicrobial activity against Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus bacterial strains, when compared with their individual components. Furthermore, the nanoaggregates also facilitate rapid wound healing without exhibiting any cytotoxic effects in mammalian cells. These nanoaggregates may become a potent component of innovative wound healing therapies.

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“…The employment of metallic nanoparticles can be particularly effective in regulating the different phases of the repair process and in promoting a faster wound closure, based on the specific ion properties. [8][9][10] Emphasis has been mainly placed so far on silver, which has been widely used in medicine for millennia due to its anti-bacterial and anti-inflammatory activity, having led to a variety of silver-containing formulations. 11 It has been shown that scaling down silver to the nanoscale (<100 nm) improves its antimicrobial activity compared with the bulk material due to the higher specific surface area.…”

Section: Introductionmentioning

confidence: 99%

<p>Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context</p>

Torre¹,

Giasafaki²,

Steriotis³

et al. 2019

IJN

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Introduction: Silver decorated mesoporous carbons are interesting systems that may offer effective solutions for advanced wound care products by combining the well-known antimicrobial activity of silver nanoparticles with the versatile properties of ordered mesoporous carbons. Silver is being used as a topical antimicrobial agent, especially in wound repair. However, while silver shows bactericidal properties, it is also cytotoxic at high concentrations. Therefore, the incorporation of silver into ordered mesoporous carbons allows to exploit both silver's biological effects and mesoporous carbons' biocompatibility and versatility with the purpose of conceiving silver-doped materials in light of the growing health concern in wound care. Methods: The wound healing potential of an ordered mesoporous carbon also doped with two different loadings of silver nanoparticles (2 wt% and 10 wt%), was investigated through a biological assessment study based on different assays (cell viability, inflammation, antibacterial tests, macrophage-conditioned fibroblast and human keratinocyte cell cultures). Results: The results show silver-doped ordered mesoporous carbons to positively condition cell viability, with a cell viability percentage >70% even for 10 wt% Ag, to modulate the expression of inflammatory cytokines and of genes involved in tissue repair (KRT6a, VEGFA, IVN) and remodeling (MMP9, TIMP3) in different cell systems. Furthermore, along with the biocompatibility and the bioactivity, the silver-doped ordered mesoporous carbons still retain an antibacterial effect, as shown by a maximum of 13.1% of inhibited area in the Halo test. The obtained results clearly showed that the silver-doped ordered mesoporous carbons exhibit both good biocompatibility and antibacterial effect with enhanced re-epithelialization, angiogenesis promotion and tissue regeneration. Discussion: These findings suggest that the exceptional properties of silver-doped ordered mesoporous carbons could be exploited in the treatment of acute and chronic wounds and that such carbon materials could be potential candidates for use in medical devices for wound healing purposes, in particular, the 10 wt% loading, as the results showed to be the most effective.

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Influence of gold nanoparticles on wound healing treatment in rat model: Photobiomodulation therapy

Abstract: The application of AuNPs in PBMT has potential to accelerate wound healing due to enhanced epithelialization, collagen deposition and fast vascularization. Lasers Surg. Med. 49:380-386, 2017. © 2016 Wiley Periodicals, Inc.

Cited by 80 publications

References 59 publications

Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

Ultrasmall Gold Nanocluster Based Antibacterial Nanoaggregates for Infectious Wound Healing

<p>Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context</p>

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