Influence of gold salts on adjuvant arthritis in the rat.

Jessop, J D; Currey, H. L. F.

doi:10.1136/ard.27.6.577

Cited by 31 publications

(10 citation statements)

References 13 publications

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“…These results are in agreement with the observations of Newbould (1963) on the effectiveness of gold sodium thiomalate in adjuvant-induced arthritis and also strengthen and extend his observations by showing that there is a dose-response relationship in suppressing adjuvant arthritis and elevating serum gold levels. These results are not, however, in agreement with reported observations of Jessop and Currey (1968), who could not produce an effect on adjuvant-induced arthritis in rats pretreated with gold sodium thiomalate.…”

Section: Discussioncontrasting

confidence: 91%

“…Since the doses of gold sodium thiomalate used in our laboratory were similar to most of those used by Jessop and Currey (1968), the divergent results may be due to a difference in experimental protocol. Some of the differences between our study and Jessop and Currey's work were strain of rat, adjuvant material, dosing regimen, and methods of evaluating the arthritic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Their effectiveness, while not consistent, has been well established (Freyberg, 1966) and their use continues. Recently, conflicting results concerning the effectiveness of gold salts on adjuvant arthritis in rats have been reported (Newbould, 1963;Jessop and Currey, 1968). Adjuvant arthritis, a crippling deformity resulting from diffuse connective tissue involvement, is considered by some authorities to be the best available experimental model of rheumatoid arthritis because of its strong clinical and pathological siinilarities to the human disease (Pearson, 1963), and because it can be effectively treated with most antiarthritic drugs it is widely used to evaluate potential therapeutic agents.…”

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confidence: 99%

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Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate.

Walz¹,

Martino²,

Misher³

1971

Annals of the Rheumatic Diseases

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Gold salts have been used in the treatment of rheumatoid arthritis for nearly 40 years. Their effectiveness, while not consistent, has been well established (Freyberg, 1966) and their use continues. Recently, conflicting results concerning the effectiveness of gold salts on adjuvant arthritis in rats have been reported (Newbould, 1963;Jessop and Currey, 1968). Adjuvant arthritis, a crippling deformity resulting from diffuse connective tissue involvement, is considered by some authorities to be the best available experimental model of rheumatoid arthritis because of its strong clinical and pathological siinilarities to the human disease (Pearson, 1963) HINDLEG VOLUME This was determined by a modified method of VanArman, Begany, Miller, and Pless (1965). On the day of assay (3 to 4 hours after drug administration), the hindlegs were immersed to the anatomical hairline into a mercury reservoir. The mercury column was connected to a Statham pressure transducer (Model P23BB, 0-5 cm. Hg.). The output from the transducer was led through an amplifier to a Hewlett-Packard digital voltmeter (Model HP-3440A), and a high gain/auto range unit (Model 3443A), and finally to a digital recorder (Model J74562A). The digital recordings were calibrated, and a linear relationship between MV and ML was obtained by placing cylinders of known volumes into the mercury reservoir. ARTHRITIC SCOREThe severity of secondary lesions in the uninjected hindleg was graded 0 to 4, depending upon the area and magnitude of involvement. DRUG ADMINISTRATIONGold sodium thiomalate (Myocrysine() was prepared at various concentrations in 0 5 per cent. benzyl alcohol and injected intramuscularly (right thigh) in a volume of 0 5 ml./kg. The drug was administered once daily (exclusive of weekend days indicated in the text) starti either on Day 0 or one week before adjuvant injection and continuing until the termination of the experiment (Day 16). Control animals were treated in an identical manner using 0 5 per cent. benzyl alcohol for the intramuscular injections. The benzyl alcohol solution was prepared with either 0 * 9 per cent. saline or water for injection.The level of significant difference between hindleg volumes, arthritic score, and body weight of drug-treated and control groups was determined by the Student's 't' test. SERUM GOLD LEVELBlood samples were obtained after the decapitation of the adjuvant arthritic rats. 0 5 mJ. aliquot of serum was diluted to 3 0 ml. with distilled water and absorption measured in a Perkin-Elmer Model 303 atomic absorption spectrophotometer (wavelength 243 -3 mjt slit 4,

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate.

Walz¹,

Martino²,

Misher³

1971

Annals of the Rheumatic Diseases

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“…(1965) 2-butoxycarbonylmethylene-4-oxothiazolidine Winter and Nuss (1966) Dexamethasone, Mefenamic acid, Phenylbutazone, Aspirin, Flufenamic acid, Indomethacin Ward and Cloud (1966) Indomethacin, Prednisolone, Phenylbutazone Currey and Ziff (1966,1967,1968) ALS (globulin) Glenn . (1966) Steroids, Indomethacin, Flufenamic acid, Phenylbutazone, Mefenamic acid, Hydrocortisone acetate Kapusta andMendelson (1967) Statolon Jessop andCurrey (1968) (Gold salts) Whitehouse and Whitehouse (1968) Lymphocyte depletion…”

Section: Discussionmentioning

confidence: 99%

Suppression of adjuvant arthritis by a new cytotoxic compound, rubidomycin.

Quagliata¹,

Sanders²,

Gardner³

1969

Annals of the Rheumatic Diseases

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“…This is mainly because the rat model is suppressed by numerous drugs used in the treatment of the human disease, as for example glucocorticoids, salicylates and other analgesics (Newbould, 1963;Winter & Nuss, 1966;Graeme, Fabry & Sigg, 1966), and immunosuppressive agents (Ward, Cloud, Krawitt & Jones, 1964). However, reports that gold salts improve adjuvant arthritis (Newbould, 1963;Walz, Di Martino & Misher, 1971) were not confirmed by Jessop & Currey (1968).…”

Section: Discussionmentioning

confidence: 98%

Blood changes in experimental arthritis in two types of genetically different rats

Eisen

Freeman²,

Loveday

et al. 1973

British J Pharmacology

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Summary1. Rats genetically resistant to dextran and other agents producing the anaphylactoid reaction (NR rats), have a higher polymorph count than do rats which react to these agents (R rats). 2. NR rats do not develop polyarthritis when a hind paw is injected intradermally with Freund's adjuvant. 3. The polyarthritis produced by an intravenous injection of Mycoplasma arthritidis culture develops more slowly in NR rats than in R rats. 4. It is not clear whether the higher polymorph count in NR rats is a main factor in determining their resistance to adjuvant-induced arthritis. IntroductionWhilst testing the sensitivity to clinical dextran of Wistar rats from different colonies, Harris & West (1963) found that more than one-fifth of the animals from one colony failed to respond with gross oedema of the extremities to the first dose and to all subsequent doses of dextran. By selective breeding experiments,

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Influence of gold salts on adjuvant arthritis in the rat.

Cited by 31 publications

References 13 publications

Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate.

Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate.

Suppression of adjuvant arthritis by a new cytotoxic compound, rubidomycin.

Blood changes in experimental arthritis in two types of genetically different rats

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