Influence of green tea on enzymes of carbohydrate metabolism, antioxidant defense, and plasma membrane in rat tissues

Khan, Sara Anees; Priyamvada, Shubha; Arivarasu, N. A.; Khan, Sheeba; Yusufi, A. N. K.

doi:10.1016/j.nut.2007.06.007

Cited by 40 publications

(15 citation statements)

References 35 publications

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“…The gene expression of G6Pase was down-regulated by intake of green tea for 28 days, indicating its chronic effect. The finding is compatible with a recent result showing that the enzymatic activity of hepatic G6Pase was lowered by 20% in normal rats given green tea as drinking fluid as compared with that in water-given rats (8). In addition, the gene expression of fatty acid synthase (FASN) was shown to be chronically down-regulated.…”

Section: Methodssupporting

confidence: 91%

Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats

et al. 2009

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Normal rats were given catechin-rich green tea as drinking fluid and the effects on hepatic gene expression were examined. The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor α in the rats given green tea for 4 weeks as compared with the water-given animals. One may expect anti-diabetic activity by catechin-rich green tea through its chronic down-regulatory effect on G6Pase expression.

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Section: Methodssupporting

confidence: 91%

Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats

et al. 2009

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“…This result is in agreement with most studies on glucose homeostasis (NOMURA et al, 2008;VENABLES et al, 2008) after green tea intake. In those studies, in which a beneficial effect of green tea in reducing glucose was observed, the amount of green tea in the diet was about 3%, six times higher than that offered in the present study (KHAN et al, 2007), and the experimental period was 16 weeks, twice as much time of the present study (BOSE et al, 2008). In this regard, it seems unlikely that the lack of effect seen here was due to low dose or short time of experimentation.…”

Section: Discussioncontrasting

confidence: 48%

“…Several studies have shown the antioxidant effect of white (ALMAJANO; VILA; GINES, 2011;CALZUOLA;GIANFRANCESCHI;MARSILI, 2006;KOUTELIDAKIS et al, 2009;KUMAR et al, 2012;SEERAM et al, 2008;THRING;HILI;NAUGHTON, 2009) and green tea (KHAN et al, 2007;KUMAR et al, 2012;PANZA et al, 2008). Since obesity caused by high-fat diet is also associated to the increase in oxidative rather than reduction in hepatic production or uptake of endogenous lipids.…”

Section: Discussionmentioning

confidence: 99%

White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice

et al. 2012

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White tea is an unfermented tea made from young shoots of Camellia sinensis protected from sunlight to avoid polyphenol degradation. Although its levels of catechins are higher than those of green tea (derived from the same plant), there are no studies addressing the relationship between this tea and obesity associated with oxidative stress.The objective of this study was to evaluate the effect of white tea on obesity and its complications using a diet induced obesity model. Forty male C57BL/6 mice were fed a high-fat diet to induce obesity (Obese group) or the same diet supplemented with 0.5% white tea extract (Obese + WTE) for 8 weeks. Adipose tissue, serum lipid profile, and oxidative stress were studied. White tea supplementation was not able to reduce food intake, body weight, or visceral adiposity. Similarly, there were no changes in cholesterol rich lipoprotein profile between the groups. A reduction in blood triacylglycerols associated with increased cecal lipids was observed in the group fed the diet supplemented with white tea. White tea supplementation also reduced oxidative stress in liver and adipose tissue. In conclusion, white tea extract supplementation (0.5%) does not influence body weight or adiposity in obese mice. Its benefits are restricted to the reduction in oxidative stress associated with obesity and improvement of hypertriacylglycerolemia.

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“…The inhibition of NQO found in this study may lead to an enhanced level of ROS. In contrast, several previously published studies reported induction of antioxidant enzymes after consumption of green tea [Khan et al, 1992;Lin et al, 1998;Khan et al, 2007;Park et al, 2011]. However, all these studies were performed in non-obese individuals and with doses of green tea exceeding those used in our study.…”

Section: Discussioncontrasting

confidence: 65%

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Bártíková¹,

Boušová²,

Matoušková³

et al. 2017

Pol. J. Food Nutr. Sci.

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Key words: monosodium glutamate-induced obesity, catechins, oxidative stress, polyphenon 60Green tea and green tea extracts (GTE) are often incorporated into diet intended to weight reduction, although the information about their effi cacy in obese individuals is insuffi cient. The present study was designed to follow up the effect of defi ned and standardized GTE in mice with obesity induced by monosodium L-glutamate. Obese mice were fed with GTE-supplemented diet in three dosage regimens: 28-day and 3-day intake of 1 g GTE in 1 kg of diet and 28-day intake of 0.1 g GTE in 1 kg of diet. The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. High doses of GTE decreased the specifi c activities of glutathione reductase and catalase and increased concentrations of malondialdehyde in blood. Specifi c activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. Our results showed that GTE did not affect average body weight and did not markedly improve antioxidant status in glutamate-induced obese mice. Moreover, intake of high doses of GTE made antioxidant defense in obese animals even worse.Unauthenticated Download Date | 5/12/18 3:35 AM

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Influence of green tea on enzymes of carbohydrate metabolism, antioxidant defense, and plasma membrane in rat tissues

Cited by 40 publications

References 35 publications

Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats

Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats

White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

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