Influence of gut microbiome on the human physiology

Srivastava, Aakriti; Prabhakar, Muhil Raj; Mohanty, Anee; Meena, Sumer Singh

doi:10.1007/s43393-021-00052-w

Cited by 8 publications

(6 citation statements)

References 141 publications

(219 reference statements)

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“…Gut microbiota consists of trillions of microbial species that harbour living organisms' intestinal tracts. The gut microbiota has the capabilities to adapt according to different foods (Srivastava et al, 2021;Lindell et al, 2022). Mealworms (Tenebrio molitor Linnaeus) can ingest and biodegrade the polyester (PS) to CO 2 and low molecular weight compounds within the gut.…”

Section: Relevance Of Microbes In Plastic Degradationmentioning

confidence: 99%

Microbial biodegradation of plastics: Challenges, opportunities, and a critical perspective

Shilpa

Basak

Meena

2022

Front. Environ. Sci. Eng.

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Section: Relevance Of Microbes In Plastic Degradationmentioning

confidence: 99%

Microbial biodegradation of plastics: Challenges, opportunities, and a critical perspective

Shilpa

Basak

Meena

2022

Front. Environ. Sci. Eng.

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“…Further, the gut microbiome’s composition and diversity vary among individuals, influenced by factors such as age, diet, and environment ( Odamaki et al, 2016 ). A balanced gut microbiome or eubiosis, is crucial for health, while an imbalance or dysbiosis, can contribute to various diseases like systemic inflammation, insulin resistance, and autoimmune and metabolic disorders ( Srivastava et al, 2022 ). Furthermore, a strong and expanding evidence base supports the influence of gut microbiota in human metabolism, particularly in relation to conditions like hyperglycaemia and hyperlipidaemia ( Kim et al, 2019 ; He & You, 2020 ; Cunningham, Stephens & Harris, 2021 ; Srivastava et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Microbiota based personalized nutrition improves hyperglycaemia and hypertension parameters and reduces inflammation: a prospective, open label, controlled, randomized, comparative, proof of concept study

Kallapura,

Prakash,

Sankaran

et al. 2024

PeerJ

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Background Recent studies suggest that gut microbiota composition, abundance and diversity can influence many chronic diseases such as type 2 diabetes. Modulating gut microbiota through targeted nutrition can provide beneficial effects leading to the concept of personalized nutrition for health improvement. In this prospective clinical trial, we evaluated the impact of a microbiome-based targeted personalized diet on hyperglycaemic and hyperlipidaemic individuals. Specifically, BugSpeaks®-a microbiome profile test that profiles microbiota using next generation sequencing and provides personalized nutritional recommendation based on the individual microbiota profile was evaluated. Methods A total of 30 participants with type 2 diabetes and hyperlipidaemia were recruited for this study. The microbiome profile of the 15 participants (test arm) was evaluated using whole genome shotgun metagenomics and personalized nutritional recommendations based on their microbiota profile were provided. The remaining 15 participants (control arm) were provided with diabetic nutritional guidance for 3 months. Clinical and anthropometric parameters such as HbA1c, systolic/diastolic pressure, c-reactive protein levels and microbiota composition were measured and compared during the study. Results The test arm (microbiome-based nutrition) showed a statistically significant decrease in HbA1c level from 8.30 (95% confidence interval (CI), [7.74–8.85]) to 6.67 (95% CI [6.2–7.05]), p < 0.001 after 90 days. The test arm also showed a 5% decline in the systolic pressure whereas the control arm showed a 7% increase. Incidentally, a sub-cohort of the test arm of patients with >130 mm Hg systolic pressure showed a statistically significant decrease of systolic pressure by 14%. Interestingly, CRP level was also found to drop by 19.5%. Alpha diversity measures showed a significant increase in Shannon diversity measure (p < 0.05), after the microbiome-based personalized dietary intervention. The intervention led to a minimum two-fold (Log2 fold change increase in species like Phascolarctobacterium succinatutens, Bifidobacterium angulatum, and Levilactobacillus brevis which might have a beneficial role in the current context and a similar decrease in species like Alistipes finegoldii, and Sutterella faecalis which have been earlier shown to have some negative effects in the host. Overall, the study indicated a net positive impact of the microbiota based personalized dietary regime on the gut microbiome and correlated clinical parameters.

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“…Through co-evolution, organisms make up the microbiota and the term 'gut microbiota' has been given to the overall dynamic microbial population inhabiting the GI tract of humans [2,3]. Gut microorganisms are also viewed as an 'indispensable unit' of living beings as they form a symbiotic relationship with the host and carry out numerous functions responsible for host immunity, metabolism, nutrition, and illness [4].…”

Section: Introductionmentioning

confidence: 99%

Study of altered gut microbial dynamics and their association with gestational diabetes mellitus

Srivastava

Prabhakar

Mohanty

et al. 2023

Syst Microbiol and Biomanuf

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The human gastrointestinal system is home to billions of different microbial species that coexist peacefully with the host. Age, diet, and environment affect gut microbial structure and diversity. Bacteroidetes and Firmicutes are the main gut microbial groups in humans. Human physiology is greatly affected by gut microbial metabolism and host-microbe interactions. Gestational diabetes mellitus (GDM) women have a different gut microbial makeup. However, whether these microbial changes in the stomach may be detected before the diagnosis of GDM remains unknown. This study aims to study the dynamics of gut microbe in healthy and GDM women and analyze the potential biomarkers for early detection of GDM in pregnant women. In this study, gut microbial variations have been characterized and their relationship is evaluated with GDM development. A large multi-taxon microbial shift between GDM and normal cases was evident, indicating that few microbial disruptions from early to mid-pregnancy were related to the later development of GDM. Results of linear discriminant analysis (LDA) show the variable relative abundance of 13 taxonomic groups (at the family level) between the GDM and normal groups. Moreover, 8 taxonomic groups (at the family level) were found to be present in the GDM group only. The results contribute to the gut microbiota's potential relevance as a biomarker for the early detection of GDM.

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Influence of gut microbiome on the human physiology

Cited by 8 publications

References 141 publications

Microbial biodegradation of plastics: Challenges, opportunities, and a critical perspective

Microbial biodegradation of plastics: Challenges, opportunities, and a critical perspective

Microbiota based personalized nutrition improves hyperglycaemia and hypertension parameters and reduces inflammation: a prospective, open label, controlled, randomized, comparative, proof of concept study

Study of altered gut microbial dynamics and their association with gestational diabetes mellitus

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