Influence of HA on Release Process of Anionic and Cationic API Incorporated into Hydrophilic Gel

Abstract

The properties of sodium hyaluronate (HA), such as hygroscopicity, flexibility, the ability to form hydrogels, as well as biocompatibility and biodegradability, are beneficial for the applications in pharmaceutical technology, cosmetics industry, and aesthetic medicine. The aim of this study was to prepare HA-based hydrogels doped with active pharmaceutical ingredient (API): a cationic drug—lidocaine hydrochloride or anionic drug—sodium. The interaction between the carrier and the implemented active pharmaceutical substances was evaluated in prepared systems by applying viscometric measurements, performing release tests of the drug from the obtained formulations, and carrying out FTIR and DSC. The data from release studies were analyzed using the zero-, first-, and second-order kinetics and Higuchi, Korsmeyer-Peppas, and Hixon-Crowell models. The respective kinetic parameters: the release rate constants, the half-release time and, in the case of the Korsmeyer-Peppas equation, the n parameter were calculated. The variability between the obtained release profiles was studied by calculating the difference (f1) and the similarity factor (f2) as well as employing statistical methods. It was revealed that the incorporation of the drugs resulted in an increase in the viscosity of the hydrogels in comparison to the respective drug-free preparations. The dissolution study showed that not entire amount of the added drug was released from the formulation, suggesting an interaction between the carrier and the drug. The FTIR and DSC studies confirmed the bond formation between HA and both medicinal substances.

Utilization of Multi-Ionic Interaction of Yumoto Hot Springs for Enhancing the Moisturizing Properties of Hyaluronic Acid Sodium Salt

“…Notably, the HA-HS conditions exhibited higher moisture retention percentages compared to HA-DI across all HA concentration ranges from 0.5% to 3%. The hygroscopic properties of HA [37] enable it to attract and retain water molecules from the surrounding environment effectively, thus hydrating the skin by drawing moisture from the air and deeper layers of the skin. Additionally, HA plays a role in supporting the skin's natural barrier function by maintaining adequate moisture levels in the outermost layer of the skin [38].…”

Biopolymer-Based Hydrogel Incorporated with Naproxen Sodium and Lidocaine Hydrochloride for Controlled Drug Delivery

“…The kinetic analysis was carried out using zero-, first-, and second-order kinetics as well as Higuchi and Korsmeyer-Peppas dependences [31][32][33][34]. The equations were included in our previous work [23,35,36], and they are as follows:…”

“…The measured viscosity of the formulations F1-F3 containing Nap and Lid, in comparison to the viscosity of the corresponding Lid-free hydrogels assessed in previous work [23], is listed in Table 2. It was found that the viscosity of the preparations F1-F3 was lower than the corresponding viscosity of hydrogels with Nap only.…”

“…This work was a continuation of previous studies concerning the influence of the HA on the dissolution patterns of anionic and cationic drug introduced into the hydrogel. The anionic drug was sodium naproxen (Nap) and the cationic substance was lidocaine hydrochloride (Lid) [23]. In the present work, we studied the release of Nap from HA-based matrixes in the presence of Lid.…”

“…The purpose of this work was to test the Lid's influence on the dissolution of Nap from HA-based hydrogels. It was interesting to calculate the kinetic parameters of Nap release from formulations containing Lid and to compare the parameters with the values obtained in the previous study, where Nap was released from hydrogels without Lid [23]. Moreover, the interactions between the ingredients of the composition were also studied.…”