Introduction: As mobile technology has evolved and is used extensively by most of the population, there is an increase in incidences of pain associated with the overuse of mobile phones. Pain associated with smartphone use is because of prolonged periods of time engaging with digital devices. The use of smartphones can cause various types of physical discomforts, such as neck pain, shoulder pain, and thumb pain, collectively referred to as “smartphone-related musculoskeletal disorders” (SRMDs). These medical issues arise mainly due to poor posture, repetitive movements, and prolonged use of smartphones without breaks. The impact of SRMDs on an individual’s daily life can be significant, resulting in decreased productivity, reduced quality of life, and increased healthcare costs. It is important for individuals to be aware of the risks associated with smartphone use and take steps to minimize their risk of developing SRMDs. Methods: The proposed study was an observational, questionnaire-based non-invasive study. The study was conducted in AIIMS Bhopal. The study was conducted on 130 adult males and 70 adult females. Personal and demographic details along with anthropometric measurements like Palm length, Palm breadth, and middle finger length were recorded. The level of smartphone addiction of individuals was also documented. Results: Correlations among palm length, palm breadth, length of the middle finger, smartphone size and shape, addiction level, and musculoskeletal pain were calculated. Conclusion: Present study proposes some important remedies which may minimize the musculoskeletal pain associated with the overuse of mobile phones.