Influence of HbS levels upon the hematological and clinical characteristics of sickle cell trait

Abstract

The variable concentration of HbS in individuals with sickle cell trait led us to study the relationship between HbS level and selected vascular events in 355 hospitalized black men with sickle cell trait. There were significant differences in hemoglobin concentration and mean corpuscular volume found in four groups divided by their HbS level, the lowest proportion of HbS (less than 30%) being associated with the lowest hemoglobin concentration (12.6 g/dl) and MCV (77 fl). The percent HbS did not influence the incidence of pulmonary embolism, thrombophlebitis, myocardial infarction, cerebrovascular accident, or idiopathic hematuria. Our results suggest that HbS level does not influence vascular disease, and while certain hematological alterations occur, they are very unlikely to have any clinical significance. Regardless of the proportion of HbS, sickle cell trait in black men is benign.

Different Regions of HIV-1 Subtype CenvAre Associated with Placental Localization andIn UteroMother-to-Child Transmission

“…However, the mutations identified (Table 3) include two relatively conservative K-to-R mutations. Although less conservative mutations are expected to have a stronger impact on the biochemistry of the protein product, this is not always the case-even relatively conservative amino acid substitutions may have significant biological effects (36). Although they were not associated with placental localization, it is possible that the sp-gp120 env positions associated with in utero MTCT are also a marker of placental adaptation.…”

Sickle-Cell Trait: Novel Clinical Significance

“…7,12,13,28 The degree of impairment of urinary concentration is also variable among subjects with SCT, and may be related to the percentage of hemoglobin S, which in turn is determined by the co-occurrence of an α-globin gene deletion(s). 29,30 Thus, among individuals with SCT, maximal achievable concentration of urine following administration of intranasal desmopressin acetate ranges between 530 and 845 mOsm, and is inversely correlated with the number of α-globin gene deletions. 31 In the presence of two α-globin gene deletions (HbS concentration ~29%), urine concentration is only moderately reduced, while in those with no α-globin gene deletions (HbS concentration ~42%), the ability to concentrate urine is maximally impaired.…”

Sickle cell trait and the risk of venous thromboembolism among blacks

“…On the other hand, in a study of 355 hospitalized men with SCT, HbS concentration was not related to PE. 20 However, because all subjects in this study had SCT, this study is not directly relevant to the issue of whether SCT is a risk factor for PE.Our study had limitations. The participation rate of subjects, especially case patients, was somewhat low.…”