Influence of head‐up tile and lower body negative pressure on the internal jugular vein

Ogoh, Shigehiko; Hirasawa, Ai; Shibata, Shigeki

doi:10.14814/phy2.15248

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…The authors of the article by Shigehiko Ogoh et al (2022) noticed an error in the title of their article. The word “tile” should be “tilt.” The correct article title should be Influence of head‐up tilt and lower body negative pressure on the internal jugular vein.…”

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Corrigendum: Influence of head‐up tilt and lower body negative pressure on the internal jugular vein

2022

Physiological Reports

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mentioning

confidence: 99%

Corrigendum: Influence of head‐up tilt and lower body negative pressure on the internal jugular vein

2022

Physiological Reports

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Integrative cardiovascular dose-response to graded lower body negative pressure

Whittle,

Keller,

Hall

et al. 2024

Preprint

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Background: Lower body negative pressure (LBNP) has been posited as a potential spaceflight countermeasure to counteract the physiological deconditioning related to fluid shifts in microgravity. However, open questions remain as to the magnitude of LBNP that should be applied. We systematically characterized the cardiovascular effects of LBNP and quantified the effect size of varied LBNP doses across different parts of the cardiovascular system. Methods: Twenty-four subjects (12M, 12F) were exposed to graded LBNP from 0~mmHg to -50 mmHg in 10 mmHg increments, both in supine (0°) and 15° head-down tilt postures. We measured the steady-state response in a large range of variables, including those related to the systemic circulation, cardiovascular control, and hemodynamics of the eyes and neck. Results: Building on the experimental data, dose-response curves were constructed using a Bayesian multivariate hierarchical modeling framework to quantify the effect size of every variable considered when subjected to LBNP. The methodology allows direct comparison of the variables and the underlying structural relationships between them. Further, we demonstrated the potential for LBNP to reduce jugular venous flow stagnation, which is considered one of the major health risks during human spaceflight. Conclusions: The Dose-response curves and effect sizes generated from this research effort establish the most comprehensive framework available to date that characterizes physiological responses to LBNP. These results directly inform the development of countermeasures to mitigate the negative effects of spaceflight, including cardiovascular deconditioning, spaceflight-associated neuro-ocular syndrome, and venous thromboembolism events.

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Characterization of internal jugular vein region-specific distension and flow patterns during progressive volume shifting

Cohen,

Hedge,

Greaves

et al. 2024

Journal of Applied Physiology

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Blood volume shifts during postural adjustment leads to irregular distension of the internal jugular vein (IJV). In microgravity, distension may contribute to flow stasis and thromboembolism, though the regional implications and associated risk remain unexplored. We characterized regional differences in IJV volume distension and flow complexity during progressive head-down tilt (HDT) (0°, -6°, -15°, -30°) using conventional ultrasound and vector flow imaging. We also evaluated low-pressure thigh cuffs (40 mmHg) as a fluid shifting countermeasure during -6° HDT. Total IJV volume expanded 139±95% from supine (4.6±2.7 mL) to -30° HDT (10.3±5.0 mL). Blood flow profiles had greater vector uniformity at the cranial IJV region (P<0.01) and became more dispersed with increasing tilt (P<0.01). Qualitatively, flow was more uniform throughout the IJV during its early flow cycle phase, and more disorganized during late flow phase. This disorganized flow was accentuated closer to the vessel wall, near the caudal region, and during greater HDT. Low-pressure thigh cuffs during -6° HDT decreased IJV volume at the cranial region (-12±15%; P<0.01) but not the caudal region (P=0.20), although flow uniformity was unchanged (both regions,P>0.25). We describe a distensible IJV accommodating large volume shifts along its length. Prominent flow dispersion was primarily found at the caudal region, suggesting multi-directional blood flow. Thigh cuffs appear effective for decreasing IJV volume but effects on flow complexity are minor. Flow complexity along the vessel length is likely related to IJV distension during chronic volume shifting and may be a precipitating factor for flow stasis and future thromboembolism risk.

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Influence of head‐up tile and lower body negative pressure on the internal jugular vein

Cited by 5 publications

References 37 publications

Corrigendum: Influence of head‐up tilt and lower body negative pressure on the internal jugular vein

Corrigendum: Influence of head‐up tilt and lower body negative pressure on the internal jugular vein

Integrative cardiovascular dose-response to graded lower body negative pressure

Characterization of internal jugular vein region-specific distension and flow patterns during progressive volume shifting

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