1969
DOI: 10.1172/jci105972
|View full text |Cite
|
Sign up to set email alerts
|

Influence of hemoglobin precipitation on erythrocyte metabolism in alpha and beta thalassemia

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

5
25
0

Year Published

1972
1972
2001
2001

Publication Types

Select...
5
2
1

Relationship

1
7

Authors

Journals

citations
Cited by 78 publications
(31 citation statements)
references
References 29 publications
5
25
0
Order By: Relevance
“…This resistance has been generally attributed to changes in cell shape or in intracellular protein osmotic pressure (3). While cells of patients with thalassemia major have elevated K+ fluxes (4,5), lose intracellular K+, and decrease in size upon incubation (6), cells from patients with P-thalassemia minor have not been systematically investigated with regard to membrane function.…”
Section: Introductionmentioning
confidence: 99%
“…This resistance has been generally attributed to changes in cell shape or in intracellular protein osmotic pressure (3). While cells of patients with thalassemia major have elevated K+ fluxes (4,5), lose intracellular K+, and decrease in size upon incubation (6), cells from patients with P-thalassemia minor have not been systematically investigated with regard to membrane function.…”
Section: Introductionmentioning
confidence: 99%
“…Second, the amount of i-antigen is increased on the circulating erythrocytes and the persistence of this fetal antigen has led to the suggestion that the erythrocyte membrane is immature (3,4). Finally permeability studies have established that K+ fluxes are increased both into and out ofthe erythrocyte although the intracellular K+ concentrations are unknown (5). In this study the Na+ and Ca2+ permeability as well as the binding of [3H]ouabain to erythrocytes has been measured in patients with both a-and f3-thalassemia major.…”
mentioning
confidence: 99%
“…Tail DNA from 129 sv͞ev mice was used as a template for a PCR reaction. Primers were designed according to a published BALB͞c ␤-globin major (13). An EcoRI site was added to the primers (forward) 5Ј-ACGAATTCATG-GTGCACCTGACTGAT-3Ј and (reverse) 5Ј-ACGAATTCGT-GGTACTTGTGAGCCAAGCA-3Ј.…”
Section: Methodsmentioning
confidence: 99%
“…As noted above, a major cause of erythroid cell destruction in ␣-thalassemia is the excess of unpaired ␤-globin chains that aggregate within inclusion bodies and exert a harmful effect on the cell membrane (13)(14)(15). We wondered whether the two groups of mice showing different degrees of erythrocyte destruction-indicated by the degree of reticulocytosis-were dissimilar as to the frequency and size of such inclusions.…”
Section: Fig 2 Electron Microscopic and Immunoelectron Microscopic mentioning
confidence: 99%
See 1 more Smart Citation