Influence of Hemorrhagic Shock and Subsequent Fluid Resuscitation on the Electroencephalographic Effect of Isoflurane in a Swine Model

Kurita, Tadayoshi; Morita, Koji; Fukuda, Kazushige; Uraoka, Masahiro; Takata, Kazuhide; Sanjo, Yoshimitsu; Sato, Shigehito

doi:10.1097/00000542-200512010-00013

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…The median (range) summarized anesthetic depth score was 4 (3)(4)(5) in both groups, while the median (range) BSR was 3 (0-27) in the propofol group, and 2 (1-53) in the alfaxalone group. EEG was evaluated in the last seven pigs of the experiment.…”

Section: Resultsmentioning

confidence: 93%

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Macrocirculatory Parameters and Oxygen Debt Indices in Pigs During Propofol Or Alfaxalone Anesthesia When Subjected to Experimental Stepwise Hemorrhage

et al. 2021

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Background: Pigs are anesthetized when used for emergency procedures live tissue training (LTT) of civilian and military medical personnel or for experimental purposes, but there is a paucity in the literature regarding anesthesia of pigs for this purpose.Objective(s): The main goals of the study were to compare oxygen debt, macrocirculatory parameters, and time to cardiac arrest between pigs in hemorrhagic shock and anesthetized with propofol-ketamine-dexmedetomidine or alfaxalone-ketamine-dexmedetomidine.Design: A prospective, non-blinded randomized study design was used. Sixteen pigs were randomized in blocks of four to be anesthetized with either propofol-ketamine-dexmedetomidine (n = 8) or alfaxalone-ketamine-dexmedetomidine (n = 8) as a continuous infusion.Interventions: Premedication with ketamine 15 mg kg−1 and midazolam 1 mg kg−1 was given i.m. Anesthesia was maintained with propofol 8 mg kg−1 h−1 or alfaxalone 5 mg kg−1 h−1 combined with ketamine 5 mg kg−1 h−1 and dexmedetomidine 4 μg kg−1 h−1 i.v. A stepwise, volume-controlled model for hemorrhage was created by exsanguination.Main Outcome Measures: Indices of oxygen debt (lactate, base excess, and oxygen extraction), macrocirculatory (PR, SAP, DAP, MAP, and CI, SVI, and TPR) variables, and time to death was compared between groups.Results: Pigs in the alfaxalone group had significantly higher SAP than pigs given propofol. No difference in other macrocirculatory variables or indices of oxygen debt could be found. A blood loss of 50% of the total blood volume or more was possible in most pigs with both anesthetic regimes.Conclusions: Pigs anesthetized with propofol or alfaxalone combined with ketamine and dexmedetomidine tolerated substantial blood loss.

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Section: Resultsmentioning

confidence: 93%

“…In two other studies in pigs anesthetized with propofol and remifentanil exsanguination of 35-55% of the blood volumes increased the heart rate only by ∼30% from baseline (3,4). This is relatively modest compared with findings in pigs anesthetized with pure isoflurane anesthesia (5,6).…”

Section: Introductionmentioning

confidence: 81%

Macrocirculatory Parameters and Oxygen Debt Indices in Pigs During Propofol Or Alfaxalone Anesthesia When Subjected to Experimental Stepwise Hemorrhage

et al. 2021

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“…El EC 50 de isoflurano con frecuencia espectral disminuyó de 1,12% a 0,99%, aún después de la reanimación con coloides. Junto a lo anterior, los tiempos de equilibrio de la Fe/ Fi disminuyeron producto de la menor captación de gas, producto de la disminución del débito cardíaco, dando una falsa impresión de mayor profundidad anestésica [11], [12].…”

Section: Drogas Inhaladasunclassified

Anestesia intravenosa en urgencia

Voullieme¹

2021

Rev. chil. anest.

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Influence of Hemorrhagic Shock and Subsequent Fluid Resuscitation on the Electroencephalographic Effect of Isoflurane in a Swine Model

Cited by 2 publications

References 17 publications

Macrocirculatory Parameters and Oxygen Debt Indices in Pigs During Propofol Or Alfaxalone Anesthesia When Subjected to Experimental Stepwise Hemorrhage

Macrocirculatory Parameters and Oxygen Debt Indices in Pigs During Propofol Or Alfaxalone Anesthesia When Subjected to Experimental Stepwise Hemorrhage

Anestesia intravenosa en urgencia

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