Influence of Hepatic Artery Ligation on Regeneration of Liver Tissue in the Rat

Wiles, Charles E.; Schenk, Worthington G.; Lindenberg, J

doi:10.1001/archsurg.1952.01260010803009

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…In previous studies ligation of the hepatic artery had no effect on the capacity for re generation of the liver after hepatectomy [6,29] but if portal blood supply was inter rupted it almost completely eliminated the capacity for hepatic regeneration [18]. These results further support the interpretation that diversion of contents other than oxygen is of importance when the liver is deprived of portal blood.…”

Section: Discussionsupporting

confidence: 76%

“…In previous stud ies from our laboratory hepatic protein syn thesis was reduced 1 and 16 h following HAL [8,11]. In a recent study hepatic tissue oxy gen tension was immediately reduced follow ing clamping of the proper hepatic artery but was unaffected when portal blood flow was reduced [30], Even if arterial collaterals are seldom found primarily in rats [29] they develop rap idly after interruption of the arterial supply [6], This might be one reason why hepatic protein synthesis returned to normal 3 days after HAL. Also in man early development of collaterals was reported following HAL and might be one reason why HAL alone has not been successful in the treatment of liver tu mors [2,3], The importance of portal blood for the maintenance of normal liver function is well established.…”

Section: Discussionmentioning

confidence: 88%

“…This procedure was chosen instead of separate ligation o f the arterial branches to left and median liver lobes in order to also occlude arteries along the bile duct. In rats complete elimination o f arterial blood from all hepatic tissue was demonstrated after ligation o f the proper hepatic artery [29]. In sham-operated control animals the vessels to the left and median liver lobes were dissected free but not ligated.…”

Section: Operative Proceduresmentioning

confidence: 99%

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Changes of Protein Synthesis in Liver Tissue following Ligation of Hepatic Artery or Portal Vein in Rats

J¹,

Seeman²,

Hasselgren³

1985

Eur Surg Res

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The effects of short-term (1 h) complete liver ischemia, hepatic artery ligation (HAL) and portal vein ligation (PVL) on protein synthesis and ATP in liver tissue were studied in rats. Protein synthesis was measured by determining rate of amino acid incorporation into protein in incubated liver slices and was reduced to 34% of the control value after 1 h of complete liver ischemia. ATP was reduced from 3.2 to 0.28 µmol × g-¹ wet weight. Following HAL for 1 h, protein synthesis was reduced to 63% of control value and ATP to 2.4 µmol × g-¹ wet weight. No significant changes of protein synthesis or ATP were noticed 1 h after PVL. The results indicate that deprivation of hepatic arterial blood plays a greater role than exclusion of portal blood for impairment of protein synthesis in short-lasting liver ischemia. The effect of complete ischemia was more pronounced than the sum effect of HAL and PVL, suggesting that accumulation of metabolites and tissue acidosis might contribute to the consequences of abolished blood supply in liver ischemia. In another series of experiments the effects of HAL and PVL on protein synthesis and ATP in liver tissue were studied after 1, 3 and 7 days. Protein synthesis was reduced 1 day after HAL but normalized after 3 days, probably reflecting development of collaterals. Following PVL, protein synthesis was reduced after 1 day and remained depressed up to 7 days at which time it was 55% of the control value. ATP in liver tissue was not significantly different from the control value 1 day after HAL of PVL but was slightly reduced 7 days after PVL. Thus, the results demonstrated that hepatic protein synthesis was rapidly reduced after HAL but returned to normal after a few days. The effects of PVL developed more slowly but were more pronounced and protracted. The effects of HAL are probably caused by hypoxia while reduced protein synthesis following PVL might reflect decreased inflow to the liver of other factors of importance for protein synthesis than oxygen, e.g., amino acids and hormones.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 88%

Section: Operative Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

Changes of Protein Synthesis in Liver Tissue following Ligation of Hepatic Artery or Portal Vein in Rats

J¹,

Seeman²,

Hasselgren³

1985

Eur Surg Res

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“…While relatively independent of portal venous supply, bile flow is highly dependent upon hepatic arterial supply (39). In the isolated rat liver per fused with erythrocyte-free blood plasma at oxygen tensions ranging from 1 to 4 atm., bile flow became progressively less dependent upon perfusion rate or pressure: at 4 atm.…”

Section: Bile Secretionmentioning

confidence: 99%

Liver

Braver¹

1956

Annu. Rev. Physiol.

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“…In Case minute changes i months after the signs of altered li ligation but died The third patient sumably was liga tion 10 months only showed bioc function which hepatic occlusive episode of signs probably due to a been described devoted to the effect of ligation of 70 16-0 6-7 4-6 1-6 1-6 the hepatic artery (e.g., Cameron and Mayes, 1930, 19-5 Thus, while dogs almost always die after ligation of the hepatic artery (Rappaport, 1951), most monkeys 6-8 6-0 1-2 survive (Child, 1954) and rats may even regenerate liver tissue after hepatic resection preceded by ent suffered jaundice and itching. The ligation of the hepatic artery (Wiles, Schenk, and showed signs of parenchymatous liver Lindenberg, 1952). ied during the patient's stay in hospital.…”

mentioning

confidence: 99%

Peripheral ligation of the hepatic artery during surgery in non-cirrhotic patients

Andreassen¹,

Lindenberg²,

Winkler³

1962

Gut

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EDITORIAL SYNOPSIS A report is given on four non-cirrhotic patients in whom the hepatic artery proper was ligated for different reasons. In the post-operative course only slight signs of liver damage were present and no later sequels were observed.Ligation of the hepatic artery central or distal to the point of origin of the gastroduodenal tributary has for several years been used in the treatment of patients with cirrhosis of the liver. On the other hand it has so far been generally accepted that ligation of the hepatic artery in patients with a normal liver is followed by serious complications, especially if the hepatic artery is tied peripherally to the gastroduodenal tributary.In the present communication four non-cirrhotic patients are described, who, during surgery, had the hepatic arterial blood supply interrupted during peripheral ligation of the hepatic artery. Only slight and transient symptoms of liver damage were demonstrated in the post-operative period in these four cases.CASE REPORTS CASE 1 A woman of 64 with symptoms for four years of biliary tract disease underwent a cholecystectomy and choledochotomy. The immediate post-operative course was uneventful, but four weeks after the operation she had a severe haematemesis and was admitted to this hospital. On examination an oesophageal hiatal hernia, a slightly deformed duodenal bulb, and a diverticulum of the duodenum were found, and, though oesophagoscopy did not reveal any peptic ulcer, the bleeding was thought to be due to the hernia and a transthoracic herniotomy was performed. Two weeks after the second operation she had a second severe haematemesis and a further operation was necessary, this time a bleeding duodenal ulcer being suspected. At operation, however, no abnormality was found in the ventricle and duodenum, but during duodenotomy it was observed that the bleeding originated in the deep biliary tracts as pulsating bleeding through the papilla of Vater was seen. By choledochotomy near the cystic duct it was seen that the bleeding came from the hepatic duct. As immediate haemostasis was vital at that stage of the operation the hepatic artery was ligated distal to the pancreatic-duodenal artery after which the bleeding quickly stopped.After the operation penicillin (2 m. units twice daily) and streptomycin (1 g. daily) were given for 11 days.On the third post-operative day the serum transaminases showed slightly raised values: glutamic-oxalic acid transaminase (S-GOT) 2.8 units (normal < 17), glutamic-pyruvic acid transaminase (S-GPT) 5.5 units (normal < 1-5) but on the twelfth day after the operation all values were normal. Serum bilirubin, thymol turbidity, and alkaline phosphatases were normal postoperatively and paper electrophoresis showed the following values: Albumin 197, alpha, 070, alpha2 094, beta, 057, beta2 043, and gamma globulin 1-30 g./100 ml.The patient left the hospital well 32 days after the last operation.She was readmitted 13 months later on account of a ventral hernia. She had been completely well since the ligation o...

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Influence of Hepatic Artery Ligation on Regeneration of Liver Tissue in the Rat

Cited by 8 publications

References 3 publications

Changes of Protein Synthesis in Liver Tissue following Ligation of Hepatic Artery or Portal Vein in Rats

Changes of Protein Synthesis in Liver Tissue following Ligation of Hepatic Artery or Portal Vein in Rats

Liver

Peripheral ligation of the hepatic artery during surgery in non-cirrhotic patients

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