Influence of hepatitis delta virus superinfection on the clearance of hepatitis B virus (HBV) markers in HBV carriers in Japan

Ishiguro, Hiroshi; Tamura, Ikuo; Tsubakio, T; Kurimura, Osamu; Kurimura, Takashi

doi:10.1002/jmv.1890260108

Cited by 24 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are compatible with the published data by (Ichimura et al, 1988). They concluded that, HBeAg clearance was observed in a significantly higher proportion of HDV-superinfected carriers18/28 (64.3%) as compared with carriers without HDV infection 70/214 (32.7%) (P-value < 0.005), suggesting that HDV superinfection can be considered as an inducer factor of HBeAg clearance in HBV carriers.…”

Section: Effect Of Hdv On Hbe Ag and Hbe Absupporting

confidence: 93%

Study of the Impact of Hepatitis D Virus Infection on Chronic Hepatitis B Virus Patients in Egypt

Ahmed¹,

Sheemy²,

Sedky³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Hepatitis D virus (HDV) is a defectivevirus thatrequires the presence of hepatitis B virus (HBV) for infection. It has been estimated that approximately 5% of the global hepatitis B surface antigen (HBsAg) carriers are also co-infected with HDV, leading to a total of 10-15 million HDV carriers worldwide. In the current study, we investigated anti-HDV seroprevalance, epidemiological features and effect of HDV on HBV morbidity and presence ofHBe antigen markers among 216 HBsAg seropositive patients recruited from four hospitals in Egypt between October 2009 and October 2011. Anti-HDV assay was performed by enzyme immunoassay (EIA). Then, the HDV seropositive patients were further investigated for HBe antigen and antibody, HBV DNA and HBV genotyping.Out of 216 HBsAg positive patients, 32 (14.8%) were anti-HDV positive. This study confirmed a declining trend in the prevalence of HDV infection in Egypt. A suppressive effect of HDV on HBV replication was suggested from the lower rate of detection of HBeAg (3.13%), which is indirectly proportional to viral replication, and the higher rate of detection of HBeAb (75%) in anti-HDV positive patients.

show abstract

Section: Effect Of Hdv On Hbe Ag and Hbe Absupporting

confidence: 93%

Study of the Impact of Hepatitis D Virus Infection on Chronic Hepatitis B Virus Patients in Egypt

Ahmed¹,

Sheemy²,

Sedky³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

show abstract

“…In this study, a low HBeAg-positive rate (16.3%) was also found among HBsAg-positive drug abusers than in with other studies in Taiwan Chung et al, 1988;Liu et al, 19841. Some studies [Ichimura et al, 1988;Krogsgaard et al, 19871 indicate that HDV infection plays a role in HBeAg clearance, which is known to suppress HBV replication and, to a lesser extent, in HBsAg clearance in HBV carriers. Although the HBeAg +/HBsAg + ratio in anti-HDV+ subjects was lower than in anti-HDV-subjects, there was no statistically significant difference.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of hepatitis b virus, hepatitis d virus, and human immunodeficiency virus infections among parenteral drug abusers in southern taiwan

Chung¹,

Chen

et al. 1989

Journal of Medical Virology

View full text Add to dashboard Cite

A total of 390 parenteral drug abusers (PDAs) at the Kaohsiung Municipal Narcotics Abstention Institute were examined for markers of hepatitis B virus (HBV), hepatitis D virus (HDV), and human immunodeficiency virus (HIV). All sera were tested for hepatitis B surface antigen (HBsAg), surface antibody (anti-HBs), and core antibody (anti-HBc) by radioimmunoassay (RIA) and for antibody to HIV (anti-HIV) by enzyme-linked immunosorbent assay (ELISA). Hepatitis B e antigen (HBeAg) and antibody to HDV (anti-HDV) were also tested for HBsAg-positive serum samples. Although the HBsAg-positive rate (22.1%) among PDAs was similar to that of the general population in southern Taiwan, the HBV infection rate (99.2%) and the anti-HDV-positive rate (78.5%) among HBsAg-positive subjects were significantly higher than those of the general population in southern Taiwan (P less than 0.0001). None of the PDAs studied were positive for anti-HIV. The levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) among PDAs were significantly higher than those of the general population in southern Taiwan (P less than 0.0001). The more frequent the institutionalisation, the higher the infection rates with HBV and HDV and elevated levels of SGOT and SGPT. Horizontal transmission through parenteral drug abuse may be considered a possible reason for the significantly higher rates of HBV and HDV among parenteral drug abusers.

show abstract

“…In this study, the prevalence of HBV and HDV infection as well as risk factors for parenteral transmission were investigated in a prison with 680 intravenous drug abusers. Although HDV superinfection has generally been observed to have deleterious effects on HBsAg carriers and it results in progressive and refractory courses [Smedile et al, 1982;Rizzetto et al, 1983;Hadler et al, 19841, uneventful or even self-lim- ited clinical courses have also been reported [Chen et al, 1987a;Ichimura et al, 1988;Ambu et al, 19881. To address this, liver function tests were also studied. Subjects In August 27-29, 1986, 761 (99%) serum samples from 772 men were collected from a prison a t Yun-Lin County, located in the central part of Taiwan.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis D virus infection among intravenous drug abusers in Taiwan: Analysis of risk factors and liver function tests

Hsu

Wang

et al. 1990

Journal of Medical Virology

View full text Add to dashboard Cite

To investigate the prevalence of hepatitis D virus (HDV) and hepatitis B virus (HBV) infection among intravenous drug abusers in Taiwan, a total of 761 male prisoners, including 680 intravenous drug abusers, were studied for serological markers of HBV and HDV. Questionnaires were distributed to evaluate the risk factors for HDV infection and also to estimate the strength of association among HDV infection and the risk factors. HBV infection was common, and the positive rates of HBV markers between intravenous drug abusers and non-drug abusers were not statistically different. However, the positive rate of the antibody to HDV was significantly higher among intravenous drug abusers than among non-drug abusers (21.3% vs. 8.6%). Of 131 chronic HBV carriers with intravenous drug abuse, 119 (91%) were anti-HD positive. Using multiple logistic regression models, we found that the most important risk factor for HDV infection was hepatitis B surface antigen (HBsAg) carriage, and intravenous drug addiction the next. A matched case-control study also was conducted to compare liver function tests among both anti-HD- and HBsAg-positive group anti-HD-negative, and HBs-AG-positive group as well as those with neither positive. Statistically significant difference in liver function tests was not found. It is concluded that the HBsAg carriers with intravenous drug abuse in Taiwan are commonly HDV infected with and that the infection does not seem to affect the liver as assessed by liver function tests.

show abstract

Influence of hepatitis delta virus superinfection on the clearance of hepatitis B virus (HBV) markers in HBV carriers in Japan

Cited by 24 publications

References 19 publications

Study of the Impact of Hepatitis D Virus Infection on Chronic Hepatitis B Virus Patients in Egypt

Study of the Impact of Hepatitis D Virus Infection on Chronic Hepatitis B Virus Patients in Egypt

Seroepidemiology of hepatitis b virus, hepatitis d virus, and human immunodeficiency virus infections among parenteral drug abusers in southern taiwan

Hepatitis D virus infection among intravenous drug abusers in Taiwan: Analysis of risk factors and liver function tests

Contact Info

Product

Resources

About