Influence of high-intensity interval training and intermittent fasting on myocardium apoptosis pathway and cardiac morphology of healthy rats

Carvalho, Marianna Rabelo de; Mendonça, Maria Lua Marques de; Oliveira, Jéssica Ml; Romanenghi, Rodrigo Boniollis; Morais, Camila Souza de; Ota, Gabriel Elias; Lima, A. R. R.; Oliveira, Rodrigo Juliano; Filiú, Wander Fo; Okoshi, Katashi; Okoshi, Marina Politi; Oliveira-Junior, Silvio Assis de; Martinez, Paula Felippe

doi:10.1016/j.lfs.2020.118697

Cited by 16 publications

(10 citation statements)

References 54 publications

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“…Contrary to our study results, the findings from the study by Carvalho et al (2020) also indicated that 12 weeks of HIIT had no effect on Bax, SMAC, and caspase-8 proteins expression in the cardiac of healthy rats (30). Although the type, duration, and intensity of exercise in Carvalho et al study were similar to those in the present study, it seemed that the type of subjects was the most important reason behind the difference between the results of Carvalho et al study and those of the present study.…”

Section: Discussioncontrasting

confidence: 99%

The Effect of High Intensity Interval Training on the Intrinsic and Extrinsic Pathways of Myocardial Apoptosis in Diet-Induced Obese Rats

Astani

Bashiri

Pourrazi

et al. 2022

Hormozgan medical journal

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Background: Diet-induced obesity is associated with several cardiovascular diseases and myocardial apoptosis. This study aimed to investigate the effect of high intensity interval training (HIIT) on the myocardial apoptosis in the diet-induced obese rats. Methods: Thirty-two male rats, after an obesity induction period, were randomly selected and assigned to four groups including non-obese control (NOC; n=8), basal obese control (BOC; n=8), obese control (OC; n=8), and obese+HIIT (OT; n=8). NOC and BOC groups were sacrificed before the training period. The OT group underwent a HIIT program performed 5 times/week over 12 weeks. Rat hearts were removed 48 hours after the last training session. The Bax, Bcl-2, cytochrome-c, Bid, caspase-8, as well as caspase-3 protein expressions were analyzed using western blotting. Data were analyzed using independent t test. Results: After obesity induction period, the Bax, Bid, cytochrome-c, caspase-8, caspase-3 proteins, and Bax/Bcl-2 in BOC were found to be significantly higher than those in NOC (P=0.025, P=0.0001, P=0.013, P=0.017, P=0.01, P=0.18, respectively). However, Bcl-2 protein in BOC was detected to be significantly lower than that in NOC (P=0.025). The results obtained after completing HIIT training showed that Bid, cytochrome-c, caspase-8, caspase-3, and Bax/Bcl-2 in OT were lower than those in OC (P=0.005, P=0.039, P=0.001, P=0.04, P=0.05, respectively). However, Bcl-2 protein in OT was significantly higher than that in OC (P=0.004). No significant difference was found between OT and OC regarding Bax protein (P=0.32). Conclusion: Diet-induced obesity may have exacerbated the myocardial apoptosis through both intrinsic and extrinsic pathways. However, it seemed that HIIT training significantly prevented the increase of myocardial apoptosis in obese rats.

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Section: Discussioncontrasting

confidence: 99%

The Effect of High Intensity Interval Training on the Intrinsic and Extrinsic Pathways of Myocardial Apoptosis in Diet-Induced Obese Rats

Astani

Bashiri

Pourrazi

et al. 2022

Hormozgan medical journal

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“…Several previous animal studies suggested that the cumulative food intake of mice subjected to an IF regimen was comparable to that of the control group due to the compensatory feeding behavior induced by starvation, which became the premise for these studies to speculate that the metabolic benefits of IF are independent of caloric intake ( 25 – 27 ). However, there are also studies showing that IF significantly reduces the total food amount or weekly food intake ( 30 – 32 ). In our present study, the results posit that, although IF-OLZ mice did consume more food on non-fasting days than the AL-OLZ group during the first 4 weeks, this compensatory food intake was insufficient to offset the calorie loss caused by fasting.…”

Section: Discussionmentioning

confidence: 99%

5:2 intermittent fasting tapers food intake in the refeeding state and ameliorates metabolic disturbances in mice exposed to olanzapine

Zhang

Li²,

Yan³

et al. 2022

Front. Psychiatry

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A considerable number of patients suffer from adverse metabolic reactions caused by atypical antipsychotics (AAPs), however, current management strategies are disappointing to clinicians. Preclinical studies have consistently demonstrated that intermittent fasting (IF) has robust disease-modifying efficacy in animal models in a wide range of pathological conditions, especially obesity and diabetes. However, it is unclear what role IF can play in addressing AAPs-induced metabolic disturbances. In our study, we found that a 5:2 IF regimen significantly ameliorated the metabolic disturbances induced by olanzapine (a drug representative of AAPs) in animal models. Meanwhile, our research suggests that IF altering food intake during the refeeding phase may account for the metabolic benefit. This study provides supporting evidence regarding a potentially cost-effective intervention strategy for AAPs-induced metabolic disturbances.

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“…The cardioprotective effects induced by IF are mediated by interaction with pro-inflammatory cytokines; alternate-day-fasting reduced the amount of TNFα, IL-6, and IL-1β in aged myocardium animals together with the reduction of TGF-β1, collagen contents, and NF-κB DNA-binding activity (Castello et al, 2010 ). Other studies aimed to investigate the influence of IF (associated with exercise training) on cardiac remodeling, which reported a reduction in cardiac interstitial collagen fraction (Basilio et al, 2020 ; Carvalho et al, 2021 ), a better glycemic control, a low expression of proapoptotic gene BAX and of cytochrome c, and increased expression of the antiapoptotic protein Bcl-2 (Carvalho et al, 2021 ).…”

Section: Effects Of Dietary Interventions On Cardiovascular Metabolic Parametersmentioning

confidence: 99%

Impact of Dietary Restriction Regimens on Mitochondria, Heart, and Endothelial Function: A Brief Overview

et al. 2021

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Caloric restriction (CR) and intermittent fasting (IF) are strategies aimed to promote health beneficial effects by interfering with several mechanisms responsible for cardiovascular diseases. Both dietary approaches decrease body weight, insulin resistance, blood pressure, lipids, and inflammatory status. All these favorable effects are the result of several metabolic adjustments, which have been addressed in this review, i.e., the improvement of mitochondrial biogenesis, the reduction of reactive oxygen species (ROS) production, and the improvement of cardiac and vascular function. CR and IF are able to modulate mitochondrial function via interference with dynamics (i.e., fusion and fission), respiration, and related oxidative stress. In the cardiovascular system, both dietary interventions are able to improve endothelium-dependent relaxation, reduce cardiac hypertrophy, and activate antiapoptotic signaling cascades. Further clinical studies are required to assess the long-term safety in the clinical setting.

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Influence of high-intensity interval training and intermittent fasting on myocardium apoptosis pathway and cardiac morphology of healthy rats

Cited by 16 publications

References 54 publications

The Effect of High Intensity Interval Training on the Intrinsic and Extrinsic Pathways of Myocardial Apoptosis in Diet-Induced Obese Rats

The Effect of High Intensity Interval Training on the Intrinsic and Extrinsic Pathways of Myocardial Apoptosis in Diet-Induced Obese Rats

5:2 intermittent fasting tapers food intake in the refeeding state and ameliorates metabolic disturbances in mice exposed to olanzapine

Impact of Dietary Restriction Regimens on Mitochondria, Heart, and Endothelial Function: A Brief Overview

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