The evaluation of high-temperature-induced damage to an ordinary Portland cement concrete was carried out. Results showed that the uniaxial compressive strength of the concrete linearly decreased with the increasing exposure temperature. After a high-temperature exposure, the concrete was more easily deformed under loading. The as-received cement was dense and free of obvious holes. The cement and the aggregate were bonded tightly, and no cracks were observed. Above 200°C, dehydration and decomposition of calcium silicate hydrate during the high-temperature exposure led to small holes, formed in the cement, and microcracks at the bonding aggregate/cement interface. With the increasing exposure temperature, the small holes formed in the cement grew up and the microcracks located at the aggregate/cement interface gradually expanded into a coherent crack network. Above 600°C, the cement was significantly locally pulverized and the microcracks at the aggregate/cement interface were further broadened. Below 400°C, detected phases of the exposed mortar sample were the same as those of the as-received mortar. After exposures to 600°C and 800°C, peaks of CaO were also detected besides the pre-existing phases. The reaction between CaO and SiO2 enhanced the decomposition of CaCO3 while promoting the formation of Ca2SiO4.