Influence of highly active antiretroviral treatment (HAART) on risk factors for vertical HIV transmission

García‐Tejedor, Amparo; Maiques, Vicente; Perales, Alfredo; López‐Aldeguer, José

doi:10.1080/00016340903062836

Cited by 24 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, in France the rate of elective cesarean delivery decreased since 2000 [31]; this has also been reported elsewhere in Europe [26]: The proportion of cesarean delivery in the French perinatal cohort was 52.9% in 2005 through 2010, which was twice the general French cesarean delivery rate [38]. In the same cohort, the proportion of elective cesarean trended from 56% in 2000 to 41% in 2004, whereas that for emergency cesarean section was stable at 29% [23]. In the European Collaborative study, the elective cesarean delivery rate for HIV-infected women declined from 67% in 1999–2001 to 51% by 2005–2007, whereas the emergency cesarean rate ranged from 15 to 17% in the HAART era [24].…”

Section: Discussionsupporting

confidence: 53%

“…Most of this increased risk for morbidity is related to infection (e.g., urinary tract infection, pneumonia, wound infection, septicemia), which is elevated for all women undergoing cesarean delivery [20], such that the risks are greatest for cesarean deliveries performed after onset of labor or ruptured membranes, intermediate with scheduled cesarean delivery, and lowest with vaginal delivery [21]. Although the studies upon which existing US guidelines were made demonstrate a clear benefit in reducing MTCT that outweighs potential risks of morbidity, most were conducted before the widespread use of HAART [21–23]. As maternal viral load is significantly associated with risk of MTCT [24–30], the additional benefit of scheduled cesarean delivery when full viral suppression has been achieved through the use of HAART has been questioned [31–33], and the US guidelines, as mentioned, do not recommend elective cesarean delivery in women with undetectable viral load [4,5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Complications of cesarean deliveries among HIV-infected women in the United States

Kourtis

Ellington

Pazol

et al. 2014

Aids

View full text Add to dashboard Cite

Objective To compare rates of complications associated with cesarean delivery in HIV-infected and HIV-uninfected women in the United States and to investigate trends in such complications across four study cycles spanning the implementation of HAART in the United States (1995–1996, 2000–2001, 2005–2006, 2010–2011). Design The Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project is the largest all-payer hospital inpatient care database in the United States; when weighted to account for the complex sampling design, nationally representative estimates are derived. After restricting the study sample to women aged 15–49 years, our study sample consisted of approximately 1 090 000 cesarean delivery hospitalizations annually. Methods Complications associated with cesarean deliveries were categorized as infection, hemorrhage, or surgical trauma, based on groups of specific International Classification of Diseases 9th revision codes. Length of hospitalization, hospital charges, and in-hospital deaths were also examined. Results The rate of complications significantly decreased during the study periods for HIV-infected and HIV-uninfected women. However, rates of infectious complications and surgical trauma associated with cesarean deliveries remained higher among HIV-infected, compared with HIV-uninfected women in 2010–2011, as did prolonged hospital stay and in-hospital deaths. Length of hospitalization decreased over time for cesarean deliveries of HIV-infected women to a greater extent compared with HIV-uninfected women. Conclusion In the United States, rates of cesarean delivery complications decreased from 1995 to 2011. However, rates of infection, surgical trauma, hospital deaths, and prolonged hospitalization are still higher among HIV-infected women. Clinicians should remain alert to this persistently increased risk of cesarean delivery complications among HIV-infected women.

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Complications of cesarean deliveries among HIV-infected women in the United States

Kourtis

Ellington

Pazol

et al. 2014

Aids

View full text Add to dashboard Cite

show abstract

“…The prescription of HAART to pregnant mothers has demonstrated its effectiveness in the reduction of viral load [15,16], its safety [15] and therefore, a significantly reduced transmission rate of HIV [1,3,15,18]. We observed a significant decrease of maternal viral loads measured at the end of the pregnancy over the study period (figure 2).…”

Section: Discussionmentioning

confidence: 66%

“…The therapeutic strategy to limit MTCT has dramatically changed over time [14][15][16][17][18]. The prescription of HAART to pregnant mothers has demonstrated its effectiveness in the reduction of viral load [15,16], its safety [15] and therefore, a significantly reduced transmission rate of HIV [1,3,15,18].…”

Section: Discussionmentioning

confidence: 99%

Management of Newborns from HIV-1 Seropositive Mothers: Results of a Single Center Implementation of the French National Guidelines

Moulin¹,

Rubio²,

Monpoux³

et al. 2012

J AIDS Clinic Res

View full text Add to dashboard Cite

“…In group 2, only one baby was HIV positive and CD4 count of the mother was 352/mm 3 compared to 297/mm 3 in women whose babies were HIV negative. Garcia-Tejedor et al 11 reported that CD4 count < 500/mm 3 increased the HIV transmission three times when the mother did not take ART. However, no difference was observed if mother were receiving HAART.…”

Section: Discussionmentioning

confidence: 99%

Perinatal Transmission of HIV in Women Receiving Antiretroviral Prophylaxis/Therapy during Pregnancy with Zidovudine, Lamivudine, and Nevirapine: Experience at Tertiary Care Center in India

Arora¹,

Meena²,

Arora³

2015

Journal of Postgraduate Medicine, Education and Research

View full text Add to dashboard Cite

Objective: To compare the perinatal transmission rate, maternal and neonatal outcome among HIV positive women on triple drug antiretroviral therapy (ART) with women receiving antiretroviral (ARV) prophylaxis for prevention of mother to child transmission (MTCT). Materials and methods:This prospective study recruited all HIV positive antenatal women who delivered at Postgraduate Institute of Medical Education and Research, Chandigarh from June 2010 to December 2011. The rate of HIV perinatal transmission was calculated in the two groups. The perinatal outcome was studied in the form of birth weight, gestation at delivery, mode of delivery, maternal morbidity and mortality. Results:The overall HIV transmission rate was 13.3% (10% in ART group and 15% in ARV group). A trend was seen toward a lower MTCT among women in ARV prophylaxis group who delivered by elective cesarean section (CS) as compared to vaginal delivery (7.7 vs 16.7%). Conclusion:The vertical transmission rate of HIV was lower among women receiving triple drug ART. The mode of delivery did not affect the transmission rate in this group.

show abstract

Influence of highly active antiretroviral treatment (HAART) on risk factors for vertical HIV transmission

Abstract: HAART therapy reduces the influence of the perinatal risk factors on vertical HIV transmission.

Cited by 24 publications

References 22 publications

Complications of cesarean deliveries among HIV-infected women in the United States

Complications of cesarean deliveries among HIV-infected women in the United States

Management of Newborns from HIV-1 Seropositive Mothers: Results of a Single Center Implementation of the French National Guidelines

Perinatal Transmission of HIV in Women Receiving Antiretroviral Prophylaxis/Therapy during Pregnancy with Zidovudine, Lamivudine, and Nevirapine: Experience at Tertiary Care Center in India

Contact Info

Product

Resources

About