Influence of HLA alleles in response to treatment with pegylated interferon‐alpha and ribavirin in patients with chronic hepatitis C

Marangon, Amanda Vansan; Moliterno, Ricardo Alberto; Sell, Ana Maria; Moraes, Camila Fernanda Verdichio de; Grotto, Rejane Maria Tommasini; Pardini, Maria Inês de Moura Campos; Pauli, Dayse Sousa de; Visentainer, Jeane Eliete Laguila; Silva, Giovanni Faria

doi:10.1111/j.1744-313x.2012.01088.x

Cited by 3 publications

(2 citation statements)

References 51 publications

(41 reference statements)

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“…This phenomenon has been observed in several association studies involving DQ alleles and susceptibility to virus infections, like HIV, HPV, and HCV [20–23]. …”

Section: Discussionmentioning

confidence: 58%

Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil

Cardozo

Moliterno

Sell

et al. 2014

Journal of Tropical Medicine

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Dengue infection (DI) transmitted by arthropod vectors is the viral disease with the highest incidence throughout the world, an estimated 300 million cases per year. In addition to environmental factors, genetic factors may also influence the manifestation of the disease; as even in endemic areas, only a small proportion of people develop the most serious form. Immune-response gene polymorphisms may be associated with the development of cases of DI. The aim of this study was to determine allele frequencies in the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in a Southern Brazil population with dengue virus serotype 3, confirmed by the ELISA serological method, and a control group. The identification of the HLA alleles was carried out using the SSO genotyping PCR program (One Lambda), based on Luminex technology. In conclusion, this study suggests that DQB1∗06:11 allele could act as susceptible factors to dengue virus serotype 3, while HLA-DRB1∗11 and DQA1∗05:01 could act as resistance factors.

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“…This phenomenon has been observed in several association studies involving DQ alleles and susceptibility to virus infections, like HIV, HPV, and HCV [20–23]. …”

Section: Discussionmentioning

confidence: 58%

Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil

Cardozo

Moliterno

Sell

et al. 2014

Journal of Tropical Medicine

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“…Several aspects of T cell functionality are altered in DHF patients, including proliferation, activation status, production of cytokines, and their survival [67][68][69][70]. All these functions are influenced by specific recognition, through TCRs, of the antigen associated with HLA molecules.…”

Section: Hla and Denguementioning

confidence: 99%

HLA and Infectious Diseases

Cardozo¹,

Marangon²,

Sell³

et al. 2014

HLA and Associated Important Diseases

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HLA and Associated Important Diseases 260CD . During antigen presentation, CD and CD are intimately associated with the TCR and bind to the MHC molecule [ ].. Haplotype, linkage disequilibrium and HLA genes expression HL" genes are transmitted for Mendel segregation and allelic variant is expressed in a codominant mode. The set of HL" alleles present in each chromosome of the pair is denominated haplotype. The probability of a sibling having the same HL" haplotype as the other is %, different haplotypes is % and % are share only one haplotype [ ].Moreover, there is a fact that occurs in HL" genes called linkage disequilibrium which denotes that certain alleles occur together with a greater frequency than would be expected by chance non-random gametic association . Variations in the expected combinations of alleles in the population, more often or less often than would be expected from a random formation of haplotypes from alleles, could be related to linkage disequilibrium [ ]. For example, a determined population has a gene frequency of % for HLA-A* and % for HLA-B* , therefore the expected frequency for this haplotype would be . % . x . , the actual frequency is however, . % in this population, a higher frequency than expected, characterizing a positive linkage disequilibrium [ ].. HLA and infection diseasesThe frequency and the presence of HL" alleles vary among different populations. Studies suggest that the alleles that can confer resistance to certain pathogens are prevalent in areas with endemic diseases. Furthermore, genomic analysis in families has helped to map and identify the loci related to a number of diseases. Moreover, a number of diseases have been mapped and had their related loci identified thanks to the genomic analysis of families.

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Dendritic Cells in HIV-1 and HCV Infection: Can They Help Win the Battle?

2013

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Persistent infections with human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are a major cause of morbidity and mortality worldwide. As sentinels of our immune system, dendritic cells (DCs) play a central role in initiating and regulating a potent antiviral immune response. Recent advances in our understanding of the role of DCs during HIV-1 and HCV infection have provided crucial insights into the mechanisms employed by these viruses to impair DC functions in order to evade an effective immune response against them. Modulation of the immunological synapse between DC and T-cell, as well as dysregulation of the crosstalk between DCs and natural killer (NK) cells, are emerging as two crucial mechanisms. This review focuses on understanding the interaction of HIV-1 and HCV with DCs not only to understand the immunopathogenesis of chronic HIV-1 and HCV infection, but also to explore the possibilities of DC-based immunotherapeutic approaches against them. Host genetic makeup is known to play major roles in infection outcome and rate of disease progression, as well as response to anti-viral therapy in both HIV-1 and HCV-infected individuals. Therefore, we highlight the genetic variations that can potentially affect DC functions, especially in the setting of chronic viral infection. Altogether, we address if DCs’ potential as critical effectors of antiviral immune response could indeed be utilized to combat chronic infection with HIV-1 and HCV.

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Influence of HLA alleles in response to treatment with pegylated interferon‐alpha and ribavirin in patients with chronic hepatitis C

Cited by 3 publications

References 51 publications

Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil

Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil

HLA and Infectious Diseases

Dendritic Cells in HIV-1 and HCV Infection: Can They Help Win the Battle?

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