Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection

Abstract

These data demonstrate that host genetic factors can influence the clinical manifestations of acute HIV-1 infection and provide a functional link between HLA-B57 and viral immune control.

HIV Protective KIR3DL1 and HLA-B Genotypes Influence NK Cell Function Following Stimulation with HLA-Devoid Cells

“…HLA-B*57 is an HLA allele previously reported to be associated with slow HIV disease progression (9,(38)(39)(40). It has been reported that CD8 + T cell responses restricted by this allele may have unique qualities that influence the efficiency with which they control HIV (41)(42)(43). For example, CD8 + T cell responses restricted by HLA-B*57 contribute more to the total HIV-specific response during early infection, recognize a greater fraction of potential HIV-restricted epitopes, and are associated with a reduction in the level of the response restricted by other alleles carried by the same individual (41)(42)(43).…”

Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection

“…Hence, neutralizing antibody responses exert ''soft'' selection pressure (67), by affecting the relative fitness of different strains present in the viral quasispecies. In contrast, cellular immune responses may exert ''hard'' selection pressure (67), in which the absolute fitness of the population is affected, suggested by the correlation of CTL responses and class I HLA alleles with viral load (68,69).…”

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

“…The HLA-B*57:01 allele is associated with slower HIV-1 disease progression 15,16,17,18,19 and autoimmune reactions, including hypersensitivity, to the anti-viral drug abacavir 20,21,22 . In HIV-1-infected individuals, the expressed HLA-B*57:01 allomorph elicits robust CD8 + T-cell responses that are thought to control viremia.…”