Influence of hormonal replacement therapy on the regional cerebral blood flow in postmenopausal women

Słopień, Radosław; Junik, Roman; Męczekalski, Błażej; Halerz-Nowakowska, B; Maciejewska, Marzena; Warenik-Szymankiewicz, A; Sowiński, Jerzy

doi:10.1016/s0378-5122(03)00144-0

Cited by 34 publications

(26 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Earlier investigations indicate that women have a higher mean CBF than men (10), which declines with the onset of menopause (33). Lower CBF was also noted in hypoestrogenic states (9).…”

Section: Discussionmentioning

confidence: 96%

Cerebral blood flow is increased during controlled ovarian stimulation

Nevo¹,

Soustiel²,

Thaler³

2007

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Estrogen appears to enhance cerebral blood flow (CBF). An association between CBF and physiologically altered hormonal levels due to menstrual cycle, menopause, or exogenous manipulations such as ovariectomy or hormone replacement therapy has been demonstrated. The purpose of this study was to determine the association between ovarian stimulation and CBF in vivo by measuring blood flow in the internal carotid artery (ICA) after pituitary suppression and during controlled ovarian stimulation in women undergoing in vitro fertilization treatment cycles. ICA volume flows were measured by angle-independent dual-beam ultrasound Doppler in 12 women undergoing controlled ovarian stimulation. Measurements were performed after pituitary/ovarian suppression, in the late follicular phase, and at midluteal phase. Blood flow in the ICA increased by 22.2% and 32% in the late follicular and midluteal phases compared with the respective values obtained during ovarian suppression (P Ͻ 0.0005 and P Ͻ 0.0001, respectively). There was a significant correlation between increments in estrogen levels and increments in CBF when the late follicular phase was compared with the ovarian suppression period (r ϭ 0.8, P Ͻ 0.001). Mean blood flow velocity significantly increased (by 15.7% and 16.9%, respectively) and cerebral vascular resistance significantly decreased (by 17.6% and 26.5%) during the late follicular and midluteal phases compared with respective measures during ovarian suppression. There was a significant correlation between an increase in estrogen levels and a decrease in cerebral vascular resistance when the late follicular phase was compared with the ovarian suppression period (r ϭ Ϫ0.6, P Ͻ 0.05). These changes imply sex hormone-associated intracranial vasodilation leading to increased CBF during controlled ovarian stimulation.estrogen; progesterone; angle-independent Doppler; in vitro fertilization RECENT REPORTS HAVE SUGGESTED that the cerebral circulation may be affected by hormonal status. Increased cerebral blood flow (CBF) velocities were observed in the presence of high levels of estradiol (3,25). Progesterone was shown to increase peripheral blood flow in pigs (24) and to have neuroprotective properties in male rats (12). However, there is little information regarding the effect of estrogen and progesterone on CBF in human subjects.During controlled ovarian stimulation that is utilized for in vitro fertilization (IVF) treatment cycles, there is a significant increase in serum estradiol levels during the hyperstimulated follicular phase and the luteal phase (13). The source of estrogen during an IVF cycle is the hyperstimulated follicles in the follicular phase and the corpora lutea during the luteal phase. Progesterone levels start to increase after the induction of final oocyte maturation by human chorionic gonadotropin (hCG), and supraphysiological levels are encountered during the luteal phase (11). Progesterone is secreted during the luteal phase from multiple corpora lutea that develop after trigger of oocyte ma...

show abstract

“…Earlier investigations indicate that women have a higher mean CBF than men (10), which declines with the onset of menopause (33). Lower CBF was also noted in hypoestrogenic states (9).…”

Section: Discussionmentioning

confidence: 96%

Cerebral blood flow is increased during controlled ovarian stimulation

Nevo¹,

Soustiel²,

Thaler³

2007

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

show abstract

“…2001; Slopien et al, 2003). Increased CMR glu and CBF are likely associated, in part, with increased basal neuronal activity with estrogen treatment (Woolley et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Estrogen Influences Cocaine-Induced Blood Oxygen Level-Dependent Signal Changes in Female Rats

Febo¹,

Ferris²,

Segarra³

2005

J. Neurosci.

View full text Add to dashboard Cite

We investigated the effect of estrogen on cocaine-induced brain activity using blood oxygen level-dependent (BOLD) magnetic resonance imaging. Ovariectomized (Ovx) rats without estrogen and Ovx rats with estrogen (OvxϩE) were given a single saline or cocaine injection (15 mg/kg, i.p.) for 5 d. After 7 d of withdrawal from injections, rats were challenged with cocaine during functional imaging. Acute cocaine administration produced positive BOLD activation in the prefrontal cortex, nucleus accumbens, striatum, ventral tegmental area, and hippocampus, among other brain regions. Positive BOLD signal changes were lower in OvxϩE than in Ovx rats. With repeated cocaine administration, OvxϩE rats showed enhanced BOLD signal changes in the nucleus accumbens, ventral tegmental area, and hippocampus compared with acutely treated animals. Our results indicate that estrogen influences the effects of acute and repeated cocaine administration on BOLD signal changes. The data suggest that in females with estrogen, cocaine-induced neuronal activity is enhanced after repeated cocaine administration. It is possible that the actions of estrogen within the aforementioned brain regions potentiate the behavioral response to cocaine observed in female rats.

show abstract

“…It has been suggested that estradiol exerts these effects through a nitric oxide and cGMP-dependent mechanism [99, 169]. Interestingly, post-menopausal women exhibit approximately a 5% increase in cerebellar blood flow following estrogen replacement therapy compared to their pre-therapy blood flow measurements [143]. Further, this cerebellar blood flow increase correlates with an increase in serum levels of estradiol [143].…”

Section: Health Implicationsmentioning

confidence: 99%

The cerebellum as a target for estrogen action

Hedges

Ebner

Meisel

et al. 2012

Frontiers in Neuroendocrinology

View full text Add to dashboard Cite

This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.

show abstract

Influence of hormonal replacement therapy on the regional cerebral blood flow in postmenopausal women

Cited by 34 publications

References 22 publications

Cerebral blood flow is increased during controlled ovarian stimulation

Cerebral blood flow is increased during controlled ovarian stimulation

Estrogen Influences Cocaine-Induced Blood Oxygen Level-Dependent Signal Changes in Female Rats

The cerebellum as a target for estrogen action

Contact Info

Product

Resources

About