Influence of Human Papillomavirus on Alveolar Bone and Orthodontic Treatment: Systematic Review and Case Report

Abstract

Background: As the human papillomavirus (HPV) infections are detected in healthy oral mucosa as well as in oral lesions, dental practitioners have an important role in detecting any possible lesions that might be caused by this virus. Therefore, the aim of this study was to investigate the outcomes of orthodontic treatments and HPV infections and to report a rare case of ongoing orthodontic treatment superposed on an HPV infection. Methods: An electronic English literature research of the articles published between the years 2011–2021 was conducted between December 2021–February 2022, accessing PubMed, Web of Science, Embase, Scopus, and Google Scholar. The terms “HPV”, “orthodontics”, “orthodontic treatment”, “tooth movement”, “tooth mobility”, and “malocclusion” were searched. The following inclusion criteria were pursued: articles published in English language; studies reporting HPV infection in subjects with past or ongoing orthodontic treatment; and case reports of subjects with HPV and orthodontic treatment. Exclusion criteria were: articles in languages other than English, studies related to malignancies other than HPV and orthodontic treatment; and studies reporting patients with HPV and no orthodontic treatment. Results: Following the systematic review, which includes six papers, a case of orthodontic treatment superposed on a HPV infection is presented. Conclusion: Incumbent, postponed HPV infection on an ongoing orthodontic treatment might affect treatment outcome and patient compliance.

Dental implant considerations in patients with systemic diseases: An updated comprehensive review

“…Despite stable survival rates for this type of cancer, mortality rates have reduced during the last two decades 402 . Treatment modalities include a combination of radiotherapy (RT) and surgery 403,404 . Anatomical alterations may result from surgery; meanwhile, side effects of radiotherapy include oral mucositis, irradiation caries, xerostomia, decreased ability of bones to mend, and fibrosis of blood vessels and soft tissues 405 …”

“…402 Treatment modalities include a combination of radiotherapy (RT) and surgery. 403,404 Anatomical alterations may result from surgery; meanwhile, side effects of radiotherapy include oral mucositis, irradiation caries, xerostomia, decreased ability of bones to mend, and fibrosis of blood vessels and soft tissues. 405 As most of the bone field required for implant insertion lies inside the irradiation area or is grafted, implant treatment in patients with mouth cancer is complicated.…”