Influence of humic acid on arsenic bioaccumulation and biotransformation to zebrafish: A comparative study between As(III) and As(V) exposure

Wang, Xiaoyan; Liu, Liping; Wang, Xiangrui; Ren, Jinqian; Jia, Ping; Fan, Wenhong

doi:10.1016/j.envpol.2019.113459

Cited by 15 publications

(5 citation statements)

References 38 publications

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“…These results are consistent with literature data ( Table 4 ) for adult zebrafish specimens, within the limits of the experimental error. In particular, adult specimens showed a content of As (0.18–0.88 mg kg −1 dw) similar to As content in adult zebrafish from Wang et al [ 76 ], 0.94 ± 0.08 mg kg −1 dw, and from Boyle et al [ 33 ], 0.27–0.39 mg kg −1 dw. Larvae exposed to 5 ppm of As in a water tank showed As content about ten-fold higher (0.4–0.5 mg kg −1 ww) than larvae from this study [ 73 ].…”

Section: Discussionsupporting

confidence: 74%

“…From an eco-toxicological perspective, zebrafish have been extensively used to study heavy metals, endocrine-disrupting chemicals, and persistent organic pollutants [ 65 , 66 , 67 , 68 , 69 ]. However, in most studies, high amounts of PTEs [ 69 , 70 , 71 , 72 , 73 , 74 , 75 ], which bear no relation to their content in the environment, were added to the fish feed or the aquatic environment, whereas studies wherein “natural” contaminants content were determined in zebrafish at various life stages are scarce [ 32 , 33 , 76 ].…”

Section: Introductionmentioning

confidence: 99%

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New Eco-Sustainable Feed in Aquaculture: Influence of Insect-Based Diets on the Content of Potentially Toxic Elements in the Experimental Model Zebrafish (Danio rerio)

Truzzi

Girolametti

Giovannini³

et al. 2022

Molecules

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According to the concept of circular economy, insects represent good candidates as aquafeed ingredients. Nevertheless, there are some potential chemical risks linked with insect consumption. In this study, we reared the teleost Danio rerio, used as an experimental model, with five experimental diets characterized by increasing levels (0%, 25%, 50%, 75%, and 100%) of full-fat Hermetia illucens (Hi) prepupae, substituting for fish meal (FM) and fish oil (FO). We investigated the presence of potentially toxic elements (PTEs) Cd, Pb, Ni, As, and Hg in larval (20 days), juvenile (2 months), and adult (6 months) fish. Quantitative determinations of Cd, Pb, Ni, and As were made with an atomic absorption spectrometer; the total mercury content was determined by a direct mercury analyzer. The substitution of FM and FO with Hermetia illucens meal led to a reduction in the content of some PTEs, such as Pb, As, and Ni, in fishfeed, leading to concentrations below the legal limit of undesirable substances in animal feed. By increasing the Hi meal dietary content, we observed in the Danio rerio specimens an increase in Cd, Pb, and Ni content and a reduction in As content for all life stages. Moreover, a general increase in the content of Cd, Pb, Hg, and Ni from larvae to juvenile was measured, while the shift of Danio rerio from the juvenile to the adult stage involved a significant increase in the content of Pb, Hg, and Ni. Larvae had a reduced ability to bioaccumulate metal(loid)s compared to juveniles and adults. In conclusion, the content of PTEs in Danio rerio is influenced both by the type of diet administered and by the life stage of the animal itself. This research demonstrates the possibility of using Hi prepupae as an aquafeed ingredient without exposing fish to a chemical risk and, in perspective, allows applying these eco-sustainable diets for the breeding of edible fish species, without endangering human health.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

New Eco-Sustainable Feed in Aquaculture: Influence of Insect-Based Diets on the Content of Potentially Toxic Elements in the Experimental Model Zebrafish (Danio rerio)

Truzzi

Girolametti

Giovannini³

et al. 2022

Molecules

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“…However, Juncos et al (2019) reported that despite high arsenic levels in sh do not represent any health risk to consumers. Similarly, Liu et al (2020) found less arsenic in Chinese mitten crab collected from different locations of China and said that intake of Chinese mitten crabs had not posed any appreciable danger to human health. These ndings could be due to speci c food habits of those human populations around the study areas and other dietary factors.…”

Section: Arsenic Exposure Through Aquatic Food Animalsmentioning

confidence: 99%

“…Arsenic has a high metabolic action in accumulation in various tissues and organs of different sh species such as O. mykiss, S. trutta and Danio rerio (Juncos et al, 2019;Wang et al, 2020). The toxic effects are dose-dependent and through various mechanisms (Mekkawi et al, 2020;Tuteja et al, 2021), being chronic exposures at low doses to the higher doses for acute exposure.…”

Section: Aquatic Animal Model Using Shmentioning

confidence: 99%

Recent advancements in toxicology, modern technology for detection, and remedial measures for arsenic exposure: review

Kumari

Bharti

2022

Biotechnology and Genetic Engineering Reviews

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Arsenic toxicity is an important worldwide health problem of humans and animals due to environmental and occupational exposure through arsenic polluted water, air, soil and food items. It has a multifaceted health impact on animals, human beings, and the environment. Therefore, various experimental and clinical studies were undertaken and had been undergoing to understand its pathogenesis, identify the key biomarkers, medical and economic impact on the affected populations, timely detection and amelioration. However, despite these long-investigated studies, no conclusive information is available for prevention and control of arsenic toxicity, mainly due to complex epidemiology, scattered approach, and repetitive work. Hence, there is a need for literature that exclusively brings information on epidemiology, pathogenesis, and ameliorative measures of arsenic toxicity, which can help researchers and policymakers for effective future planning research and community control programs. In the above view, this article presents an extensive review on the current understanding of arsenic toxicity, detection methodologies, epidemiology, and remedial measures for the bene ts of researchers, academicians, and policy makers in controlling arsenic eco-toxicology and direction for direction futuristic research.

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“…If there is long-term exposure, skin changes or other health damage will occur, eventually leading to vascular disease or cancer [5]. At the same time, the detection of organic As in many aquatic products [6], and the health risks of accumulation through the food chain [7], needs to be concerned and assessed.…”

Section: Introductionmentioning

confidence: 99%

Zinc Alleviates Arsenic-Induced Inflammation and Apoptosis in the Head Kidney of Common Carp by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress

Xing

Zhang

Chi

2021

Biol Trace Elem Res

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Arsenic (As) pollution is ubiquitous in water, which shows immunotoxicity to aquatic organisms. As an indispensable regulator of gene transcription and enzymatic modification, zinc (Zn) may play a preventive and therapeutic effect on As toxicity. The purpose of this study was to investigate the interactions of As and Zn on the head kidney of common carp Cyprinus carpio. Herein the carp were treated alone or in combination with waterborne As 3+ (2.83 mg/L) and/or Zn 2+ (1 mg/L). Results suggested a head kidney-toxic effect of As exposure, which was manifested by the histopathological damage of the head kidney, elevation of nuclear translocation of pro-inflammatory nuclear factor-kappa light chain enhancer of B cells (NF-κB), and blockage of the anti-oxidative nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. The global activation of three endoplasmic reticulum (ER) stress pathways led to the execution of programmed cell death, including ER apoptosis mediated by C/EBP-homologous protein (CHOP), death receptor-mediated exogenous cell apoptosis, and the endogenous apoptosis executed by Caspases9. The combined application of Zn can significantly improve the histopathological damage of the head kidney, the imbalance of the antioxidant system, and the apoptosis outcomes due to ER stress. In conclusion, this study indicates that Zn has an antagonistic effect on the head kidney injury of common carp induced by sub-chronic As exposure. The results of this study provide basic data for the risk assessment of As accumulation in an aquatic environment and a reference for the use of Zn preparation in aquaculture.

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Influence of humic acid on arsenic bioaccumulation and biotransformation to zebrafish: A comparative study between As(III) and As(V) exposure

Cited by 15 publications

References 38 publications

New Eco-Sustainable Feed in Aquaculture: Influence of Insect-Based Diets on the Content of Potentially Toxic Elements in the Experimental Model Zebrafish (Danio rerio)

New Eco-Sustainable Feed in Aquaculture: Influence of Insect-Based Diets on the Content of Potentially Toxic Elements in the Experimental Model Zebrafish (Danio rerio)

Recent advancements in toxicology, modern technology for detection, and remedial measures for arsenic exposure: review

Zinc Alleviates Arsenic-Induced Inflammation and Apoptosis in the Head Kidney of Common Carp by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress

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