Influence of hyaluronic acid modification on CD44 binding towards the design of hydrogel biomaterials

Kwon, Mi Y.; Wang, Chao; Galarraga, Jonathan H.; Puré, Ellen; Han, Lin; Burdick, Jason A.

doi:10.1016/j.biomaterials.2019.119451

Cited by 132 publications

(94 citation statements)

References 54 publications

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“…Given its specific biological and bioactive properties, HA-based therapeutic formulations have been approved and used clinically for the treatment of arthritis and skin diseases ( 23 ). The degree of modification of HA is within 15%, less than the thresholds for affecting biological functions such as the interaction with CD44 receptors ( 36 ). Given that the biological properties of HA are highly sensitive to its molecular weight ( 37 ), we investigated the molecular size of HAPPI and found that HA backbone is still intact after the conjugation and purification process ( Fig.…”

Section: Discussionmentioning

confidence: 99%

A polymer-based systemic hemostatic agent

et al. 2020

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Uncontrolled noncompressible hemorrhage is a major cause of mortality following traumatic injuries in civilian and military populations. An injectable hemostat for point-of-care treatment of noncompressible hemorrhage represents an urgent medical need. Here, we describe an injectable hemostatic agent via polymer peptide interfusion (HAPPI), a hyaluronic acid conjugate with a collagen-binding peptide and a von Willebrand factor–binding peptide. HAPPI exhibited selective binding to activated platelets and promoted their accumulation at the wound site in vitro. In vivo studies in mouse tail vein laceration model demonstrated a reduction of >97% in both bleeding time and blood loss. A 284% improvement in the survival time was observed in the rat inferior vena cava traumatic model. Lyophilized HAPPI could be stably stored at room temperature for several months and reconstituted during therapeutic intervention. HAPPI provides a potentially clinically translatable intravenous hemostat.

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Section: Discussionmentioning

confidence: 99%

A polymer-based systemic hemostatic agent

et al. 2020

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“…The formulation containing hyaluronic acid was found to perform more favorably [75]. Although it was not discussed, the use of hyaluronic acid might be beneficial due to a favorable interaction of its N-acteylglucosamine units with CD44 [76,77] and mannose receptors [78]. Chitosan and chitosan-folate were further used to functionalize oleic acid-based nanoemulsions loaded with rifampicin, which were nebulized to render adequate respirability (MMAD of 3-4 µm and FPF of 62-73%).…”

Section: Delivery Of Antibioticsmentioning

confidence: 99%

Multifunctional Nanocarriers for Lung Drug Delivery

Pontes

Grenha

2020

Nanomaterials

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Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical situations is frequent. These include the surface engineering of the carriers by means of altering the material structure (i.e., chemical modifications), the addition of specific ligands so that predefined targets are reached, or even the tuning of the carrier properties to respond to specific stimuli. The devised strategies are mainly directed at three distinct areas of lung drug delivery, encompassing the delivery of proteins and protein-based materials, either for local or systemic application, the delivery of antibiotics, and the delivery of anticancer drugs—the latter two comprising local delivery approaches. This review addresses the applications of nanocarriers aimed at lung drug delivery of active biological and pharmaceutical ingredients, focusing with particular interest on nanocarriers that exhibit multifunctional properties. A final section addresses the expectations regarding the future use of nanocarriers in the area.

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“…Hyaluronic acid (HA), a non-sulfated glycosaminoglycan, is abundantly present in the ECM of the skin and many other major organs and has tissue-specific functions (Papakonstantinou, Roth, & Karakiulakis, 2012). HA has been shown to promote cellular proliferation and migration, and blood vessel formation during tissue injury (Gerecht et al, 2007; Hanjaya-Putra et al, 2012; Kwon et al, 2019; Shen et al, 2014). HA contains cell-binding motifs and has been widely used for surface modification of biomaterials to support cell survival and proliferation (Highley, Prestwich, & Burdick, 2016; Khetan & Corey, 2019; Solis et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

An In situ Collagen-HA Hydrogel System Promotes Survival and Preserves the Proangiogenic Secretion of hiPSC-derived Vascular Smooth Muscle Cells

Dash

Duan

Kyriakides

et al. 2020

Preprint

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Human induced pluripotent stem cell-derived vascular smooth muscle cells (hiPSC-VSMCs) with proangiogenic properties have huge therapeutic potential. While hiPSC-VSMCs have already been utilized for wound healing using a biomimetic collagen scaffold, an in situ forming hydrogel mimicking the native environment of skin offers the promise of hiPSC-VSMC mediated repair and regeneration. Herein, the impact of a collagen type-I-hyaluronic acid (HA) in situ hydrogel crosslinked using a PEG based cross-linker on hiPSC-VSMCs viability and proangiogenic paracrine secretion was investigated. Our study demonstrated increases in cell viability and maintenance of proangiogenic growth factor secretion. The optimally cross-linked and functionalized collagen type-I/HA hydrogel system developed in this study shows promise as an in situ hiPSC-VSMC carrier system for wound regeneration.

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Influence of hyaluronic acid modification on CD44 binding towards the design of hydrogel biomaterials

Cited by 132 publications

References 54 publications

A polymer-based systemic hemostatic agent

A polymer-based systemic hemostatic agent

Multifunctional Nanocarriers for Lung Drug Delivery

An In situ Collagen-HA Hydrogel System Promotes Survival and Preserves the Proangiogenic Secretion of hiPSC-derived Vascular Smooth Muscle Cells

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