Influence of hydrogel structure on the processes of water penetration and drug release from mixed hydroxypropylmethyl cellulose/thermally pregelatinized waxy maize starch hydrophilic matrices

Michailova, Victoria; Titeva, St; Kotsilkova, Rumiana; Krusteva, E.; Minkov, E

doi:10.1016/s0378-5173(01)00706-2

Cited by 63 publications

(26 citation statements)

References 20 publications

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“…11,35,36) In this section a study of the hydration rate of the matrices has been carried out, in order to obtain more information about the critical points observed in the study of drug release.…”

Section: Study Of Water Uptake Profiles and Swelling Kineticsmentioning

confidence: 99%

Study of the Critical Points in Lobenzarit Disodium Hydrophilic Matrices for Controlled Drug Delivery

Miranda

Millán

Caraballo

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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The hydrophilic matrices are one of the most used types of Controlled Release Systems in the world. In comparison with other Controlled Release Devices, they have the advantage of their low cost and simple technology, that facilitates their application to an important sector of the population, as well as their safety against the dose dumping (accidental fast release of the whole drug dose).1) Another advantage of these matrices concerns the drug release kinetics. Using these systems, it is possible to obtain a variety of release kinetics, including in some cases zero-order release kinetics.2)The study of hydrophilic matrices is a difficult task due to its complex and disordered structure. A number of publications have reported studies about the mechanisms of drug release from hydrophilic matrices. [3][4][5][6][7][8][9][10][11] In recent works, our research group has applied the percolation theory to study the release and hydration rate of hydrophilic matrices, in order to contribute to the rationalization of the design of these controlled release systems and to obtain a better knowledge of the processes that occur during the release of the drug. [12][13][14] Percolation Theory is a statistical theory that studies disordered or chaotic systems where the components are randomly distributed in a lattice. This theory has wide application in many scientific disciplines and was introduced by Leuenberger et al. in the pharmaceutical field in 1987 to improve the characterization of solid dosage forms. [15][16][17][18][19] Our research group is employing the percolation theory in order to describe solid forms, in concrete controlled release inert matrix systems. 15,16,[20][21][22][23][24][25][26] One of the most important parameters of percolation theory is the percolation threshold, where there is a maximum probability of appearance of an infinite or percolating cluster of a substance and some properties of the system change suddenly. A cluster is defined as a group of neighboring occupied sites in the lattice and is considered infinite or percolating when it extends from one side to the rest of the sides of the lattice, i.e. percolates the whole system. 27)The application of this theory to study the release and hydration rate of hydrophilic matrices allowed for first time to explain the changes in release and hydration kinetic of swellable matrices type controlled delivery systems. [12][13][14] According to this theory, the critical points observed in dissolution and water uptake studies can be attributed to the existence of excipient percolation thresholds. The knowledge of these thresholds is very important to optimize the design of swellable matrix tablets. Above the excipient percolation threshold an infinite cluster of this component is formed, controlling the hydration and release rate. Below this threshold the excipient does not percolate the system and, as a consequence, the drug release can not be controlled. It has to be emphasized that the infinite cluster of excipient responsible for the drug release contro...

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Section: Study Of Water Uptake Profiles and Swelling Kineticsmentioning

confidence: 99%

Study of the Critical Points in Lobenzarit Disodium Hydrophilic Matrices for Controlled Drug Delivery

Miranda

Millán

Caraballo

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The addition of glycerol provides increased free volume between starch polymeric chains and more hydrophilic active sites in the film due to the glycerol hydroxyl groups which improve film water affinity and aqueous penetration. This results in an increase in hydration velocity and in drug release (Mali, 2005;Michailova, 2001;Galietta et al, 1998).…”

Section: Hydroxycinnamic Derivatives Release From Starch/ Glycerol/momentioning

confidence: 99%

Mechanical properties and total hydroxycinnamic derivative release of starch/glycerol/Melissa officinalis extract films

Rechia

Morona

Zepon

et al. 2010

Braz. J. Pharm. Sci.

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The aim of this study was to investigate the mechanical properties of starch/glycerol/Melissa officinalis, a topical drug delivery system for labial herpes treatment. Four films were prepared with different concentrations of starch, glycerol, and Melissa officinalis extract. The results revealed that increasing the glycerol concentration in the film reduced elasticity modulus and tensile strength, exhibiting a plasticizing effect. The increase in free volume resulted in increased release of hydroxycinnamic derivatives expressed as rosmarinic acid. Uniterms

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“…However, starch cannot fit into some controlled drug delivery systems, as many drugs are released quickly from the starch based systems, due to considerable swelling and quick enzymatic degradation in biological systems [9,11]. One of the efficacious mechanisms is introduced in this study to improve the properties of starch by blending it with PEG, which is extensively employed in pharmaceutical and biomedical fields.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Drug Delivery Applications of Polyethylene Glycol/Corn Starch Microspheres

Mary¹,

Pingala²,

Sheetal³

et al. 2017

Asian J. Chem.

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The tablet form of microspheres for oral drug delivery system was prepared by the phase separation method by using the blends of polyethylene glycol (PEG) and corn starch in different ratios. Ciprofloxacin hydrochloride was used as a model drug to study the sustained release of drug from the vehicle. The as prepared microspheres were characterized by optical microscopy to analyze the morphology and size. The result shows that the average sphere size was found to be in the range of 10 µ to 40 µ. Decrease in the size of microspheres with agglomeration was observed with the increase in concentration of polyethylene glycol. Drug delivery study was carried out in the USP dissolution apparatus and the release kinetics was measured by using UV-visible spectrometer at the λmax of 278 nm. The results indicate that the release kinetics varies with the ratio of polyethylene glycol and corn starch present in the microspheres and certain formulations shows sustained release of the drug. Based on the obtained results these blends can be proposed as a drug delivery vehicle for the sustained release of ciprofloxacin.

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Influence of hydrogel structure on the processes of water penetration and drug release from mixed hydroxypropylmethyl cellulose/thermally pregelatinized waxy maize starch hydrophilic matrices

Cited by 63 publications

References 20 publications

Study of the Critical Points in Lobenzarit Disodium Hydrophilic Matrices for Controlled Drug Delivery

Study of the Critical Points in Lobenzarit Disodium Hydrophilic Matrices for Controlled Drug Delivery

Mechanical properties and total hydroxycinnamic derivative release of starch/glycerol/Melissa officinalis extract films

Preparation, Characterization and Drug Delivery Applications of Polyethylene Glycol/Corn Starch Microspheres

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