Influence of Hydrophobicity on the Ion Exchange Selectivity Coefficients for Aromatic Amines

Kril, Michael B.; Fung, Ho‐Leung

doi:10.1002/jps.2600790517

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…lipophilicity ranging from log P 0.89 for PSE to log P 4.92 for Benfluorex) [20], the achievement of analytically suitable retention times was only possible by performing a gradient elution method. Different columns, mobile phases, and elution programs were tested.…”

Section: Resultsmentioning

confidence: 99%

A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules

Russo

Barbato

Grumetto

2016

Journal of Pharmaceutical and Biomedical Analysis

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Section: Resultsmentioning

confidence: 99%

A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules

Russo

Barbato

Grumetto

2016

Journal of Pharmaceutical and Biomedical Analysis

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“…In general, the equilibrium constant is determined by both electrostatic and hydrophobic forces. 26 With the drug-loading capacities of SP C25 MS and HM-MS being 32.8% and 33.6%, respectively, the hydrophobic modification seems to have no influence on the drug-loading capacity because the property of the bulk matrix is not altered (as evidenced by the swelling ratio). However, with the hydrophobicity being significantly increased after coating, EU-MS shows a higher drug loading capacity (42.5%) than that of either SP C25 MS or HM-MS.…”

Section: Drug Loading Into the Msmentioning

confidence: 96%

“…The functionality of the MS (before and after modifications) was determined by a modification of the procedure reported by Kril et al 26 Briefly, 0.2 g of MS was first incubated overnight with 20 g of 1 N hydrochloric acid (HCl) with gentle stirring. After the MS settled, the supernatant was removed with a pipette and fresh 1 N HCl was added.…”

Section: Determination Of Ion-exchange Capacitymentioning

confidence: 99%

Synthesis and Characterization of Surface‐Hydrophobic Ion‐Exchange Microspheres and the Effect of Coating on Drug Release Rate

Liu

Ballinger

et al. 2000

Journal of Pharmaceutical Sciences

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“…4,5 In a previous paper, 6 the selective collection of monovalent ion on an anion-exchange resin modified with Demol N (the polycondensation product of naphthalene sulfate and formaldehyde, made by Kao Chemicals Co., Ltd., Tokyo, Japan), anionic polyelectrolyte, was reported.…”

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confidence: 99%

Ion-Exchange Selectivity of Anion Exchange Resin Modified with Polystyrenesulfonic Acid

et al. 2004

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The separation and concentration of various ions have received considerable interest in various fields. The separation process using an ion-exchange resin is simple and advantageous for the concentration of trace ions in dilute solutions. Generally, multivalent ions are prior exchanged onto the ion-exchange resin to monovalent ions. Thus, the selective separation of monovalent ions in the presence of multivalent ions is difficult. To improve the ion-exchange selectivity, various modification processes were examined.Most of these improved a modification of chelate compounds on the anion-exchange resin for the selective collection of the metal cation, 1-3 and of hydrophilic compounds on the ion exchange resin for selective collection of hydrophilic ions. 4,5 In a previous paper, 6 the selective collection of monovalent ion on an anion-exchange resin modified with Demol N (the polycondensation product of naphthalene sulfate and formaldehyde, made by Kao Chemicals Co., Ltd., Tokyo, Japan), anionic polyelectrolyte, was reported.The ionexchange rate of multivalent anion becomes slower than that of monovalent anions. In this work, the influences of the modified condition and structure of polyelectrolyte on the ion-exchange reaction were examined. The modification layer may be controlled by using polystyrenesulfonic acid, due to the more linear polyelectrolyte structure and variation in the polymerization degree. Furthermore, the modified resin was applied to separate the nitrate ion from the sulfate ion in aqueous solution. Experimental ApparatusA sample solution was analyzed by ion chromatography composed of a pump (L-6000, Hitachi, Tokyo, Japan), a conductivity detector (L-3720, Hitachi) and a column oven with sample injector (L-5020, Hitachi). The separation column was a Showdex IC I-524A (φ4.6 × 100 mm, Showa Denko K. K., Tokyo, Japan). The analytical signals were recorded and processed with a chromato integrator (D-2500, Hitachi). ReagentsA gel-type anion exchange resin (Amberlite IRA-400, Organo Co., Ltd., Tokyo, Japan) in a chloride form (0.40 -0.53 mm) was used. Polystyrenesulfonic acid, ps-50 and ps-100 (TOSOH Corp., Tokyo, Japan) were used to form a modification layer on the surface of the anion-exchange resin. The polymerization degrees of polystyrenesulfonic acid polymer were 50 and 100, respectively. All other reagents used were of analytical grade. Modification of anion-exchange resinThe anion-exchange resin was pretreated with a sufficient sodium hydroxide solution (2 mol l -1 ). The pretreated resin was thoroughly washed with water. Ten milliliters of the anionexchange resin in a hydroxide form were introduced into a 200 ml round-bottomed flask, and 100 ml of 20 wt% polystyrenesulfonic acid solution was added. The mixture was stirred for 8 h at 90˚C in a water bath. Then modified resin was filtered and washed sufficiently with water. The modified resin was kept wet. Ion exchange procedureTwo milliliters of modified resin were introduced into a 300 ml flask, and several washings were made with water. Aft...

show abstract

Influence of Hydrophobicity on the Ion Exchange Selectivity Coefficients for Aromatic Amines

Cited by 7 publications

References 18 publications

A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules

A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules

Synthesis and Characterization of Surface‐Hydrophobic Ion‐Exchange Microspheres and the Effect of Coating on Drug Release Rate

Ion-Exchange Selectivity of Anion Exchange Resin Modified with Polystyrenesulfonic Acid

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