Influence of Hypertonic Salt Solutions on the Motility of Normal and of Obstructed Intestine

Ochsner, Alton; Gage, I. M.; Cutting, Reginald A.

doi:10.1001/archsurg.1933.01170100116007

Arch Surg

1933

DOI: 10.1001/archsurg.1933.01170100116007

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Influence of Hypertonic Salt Solutions on the Motility of Normal and of Obstructed Intestine

Alton Ochsner¹,

I. M. Gage²,

Reginald A. Cutting³

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1936

1986

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Cited by 8 publications

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References 17 publications

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“…In terms of electrolyte imbalances, hypochloraemia is a more likely contributing factor which has received little attention to date. In man, a marked decrease in chloride is similarly present in clinical cases and replacement therapy is necessary for return of gastrointestinal propulsion (Oschner, Gage and Cutting 1933;Levy and Nora 1946;Streeten and Ward-McQuaid 1952). Chloride removal has been shown to inhibit contractions of guinea pig smooth muscle in vitro (Rangachari, Triggle and Daniel 1982).…”

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confidence: 99%

Pathophysiology of equine postoperative ileus: Effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model

Gerring

Hunt

1986

Equine Veterinary Journal

109

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Summary An experimental model of postoperative ileus was developed in ponies using trauma to, and exposure of, a length of small intestine which gave rise to a reproducible and reversible set of changes in gut activity. This was assessed by recordings of electrical and mechanical activity and by propulsion of spheres from stomach to anus. Activity was depressed, especially in the stomach and colon, and transit was slowed. All drugs given increased electromechanical activity but propranolol was the least effective and did not alter the delayed transit of spheres. Yohimbine was more effective and the addition of bethanechol produced a little extra propulsive action. Metoclopramide had the best effect, virtually returning transit to normal and was the only drug fully restoring coordination of gastric and small intestinal activity which was disrupted by the ileus procedure. Loss of gastroduodenal coordination is probably the central lesion in equine ileus and may be mediated by dopamine.

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mentioning

confidence: 99%

Pathophysiology of equine postoperative ileus: Effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model

Gerring

Hunt

1986

Equine Veterinary Journal

109

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Mechanical Decompression of the Intestine in Treatment of Ileus

Storck¹

1936

Arch Surg

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Intravenous injection of hypertonic sodium chloride solution in the treatment of some conditions of low blood-pressure

Walker¹

1936

Journal of British Surgery

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HYPERTONIC sodium chloride solution has been used intravenously for several different purposes. It has been given to reduce an increased intracranial pressure from edema or haemorrhage ;I to promote intestinal motility in cases of paralytic ileus ;2 and in cholera3 it has been given in order to attract water to the blood, which is viscous owing to extreme dehydration of the body. It has not been in general use for the purpose of raising a lowered blood-pressure, although it has been suggested by Graham4 that a pint of 1.2 per cent sodium chloride should be given to raise the blood-pressure in diabetic coma, as in this condition the tissues lack water and chlorine, and sodium chloride also helps to neutralize acetone bodies. Other workers have put forward objections to the use of hypertonic solutions in the treatment of shock. BaylissY5 in his Oliver Sharpey Lectures of 1918, reviewed the physiological and therapeutic action of various solutions that could be employed by intravenous injection for the treatment of wound shock. He came to the conclusion that a hypertonic solution of sodium chloride was inadvisable as he found the effect transitory and he had noticed unpleasant symptoms of gasping respiration and slowing of the heart. He stated that he believed it undesirable to add to the saline content of the organism, which is an interesting observation when considering the recent treatment of Addison's disease, with its associated low blood-pressure, by sodium If it is undesirable to add to, it seems essential to maintain, the balance of circulating sodium chloride, both on account of its chemical and of its physical properties.MacFee and Baldridge,s also when considering the infusion treatment of shock, state that they ' see small logic in the use of hypertonic solutions ', because of the temporary hydraemia, rapid excretion by the kidneys, and finally a loss rather than gain of fluid.Cushing and Foleyg find that the raised blood-pressure may be an objection to the use of hypertonic saline intravenously for reducing intracranial tension.With due regard for the objections mentioned above, the present series of observations were made on 53 cases. I n 49 of these hypertonic saline was injected intravenously with the object of raising a lowered blood-pressure before, during, or after operation. Most cases received 40 C.C. of a 30 per cent solution (12 grm.) of sodium chloride. Blood-pressure records were kept which show the rapidity and duration of the reaction. The two cases which suggested the possibility of using small quantities of strongly hypertonic salt solution for its rapid stimulating effect on the circulation happened to occur on the same day. In the first case 30 C.C. of 30 per cent sodium chloride solution were injected intravenously, with the aim of reducing intracranial

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Influence of Hypertonic Salt Solutions on the Motility of Normal and of Obstructed Intestine

Cited by 8 publications

References 17 publications

Pathophysiology of equine postoperative ileus: Effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model

Pathophysiology of equine postoperative ileus: Effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model

Mechanical Decompression of the Intestine in Treatment of Ileus

Intravenous injection of hypertonic sodium chloride solution in the treatment of some conditions of low blood-pressure

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