Influence of hypothyroidism induced at prepuberty on epididymal lipids and the number and motility of spermatozoa in rats*

Kumar, P. N. S.; Aruldhas, M. M.; Juneja, Sanjay

doi:10.1111/j.1365-2605.1994.tb01252.x

Cited by 14 publications

(7 citation statements)

References 38 publications

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“…animals is in agreement with previous reports showing decreased sperm motility in hypothyroid rats (Chandrasekhar et al 1985, Kumar et al 1994. Since the reduction of swimming velocities of spermatozoa from the epididymis of these animals could be rescued by T4 injections (Del Rio et al 1998), it was assumed that TH directly acted on the epididymis since TH binding to the epididymal nuclei has been demonstrated (Del Rio et al 2000).…”

Section: Trbsupporting

confidence: 91%

Male congenital hypothyroid Pax8−/− mice are infertile despite adequate treatment with thyroid hormone

Wistuba¹,

Mittag²,

Luetjens³

et al. 2007

Journal of Endocrinology

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Severe forms of congenital hypothyroidism lead to serious clinical symptoms if thyroid hormone replacement therapy is not instituted immediately after birth. In this study, Pax8mice that are born without a thyroid gland were used as an animal model to study the consequences of congenital hypothyroidism. As expected, adequate treatment of these animals with thyroxine restored the general deficits of congenital hypothyroidism; however, Pax8-deficient male mice were infertile. We report here that in these mice, the efferent ducts and epididymides are either absent or the efferent ducts exhibit a reduced lumen and extensive connective tissue, which appears to impair testicular drainage and subsequently leads to complete absence of spermatozoa from the epididymis. The results suggest that, starting with the onset of pubertal testicular fluid secretion, a backpressure is created in the testis by the absence of efferent ducts or constriction of their tubule lumen when present. This subsequently leads to secondary disorganization of the seminiferous epithelium that increases with age, resulting in mixed atrophy of the testis in the adult. Serum testosterone levels as well as mRNA expression of anterior pituitary hormones are in the normal range, indicating that the observed infertility is not due to hormonal imbalance, but rather to a developmental defect of the efferent ducts. The demonstration of Pax8 expression in the epithelia of the epididymis and the efferent ducts suggests a direct morphogenic role of Pax8 in the development of these organs. It remains to be elucidated whether congenital hypothyroid male patients with mutations in the Pax8 gene are similarly affected.

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Section: Trbsupporting

confidence: 91%

Male congenital hypothyroid Pax8−/− mice are infertile despite adequate treatment with thyroid hormone

Wistuba¹,

Mittag²,

Luetjens³

et al. 2007

Journal of Endocrinology

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“…Our results are in agreement with previous articles that disclosed histological alterations in testes of hypothyroid men [3] and rats [10,14]. The pattern of sperm motility changes during epididymal transit.…”

Section: Discussionsupporting

confidence: 93%

Epididymal Scanning Electron Microscopy Study in Hypothyroid Rats

Rio

Palaoro²,

Blanco³

et al. 2001

Archives of Andrology

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The purpose of this research was to investigate, using scanning electron microscopy, the effect of hypothyroidism on the ultrastructure of the rat cauda epididymis. Thyroidectomy was obtained by ip injection of 270 muCi of 131I per rat. One month later, several portions of cauda epididymis were examined. Morphological and physiological differences were detected in the cauda epididymis of the hypothyroid animals when compared to the control normal rats. The hypothyroid condition was associated with important changes in the luminal surface of the cauda epididymis epithelium. Broken, oblique, and loss of stereocilia, denuded epithelial cells, and flattening of the tubule were observed. The results confirm that hypothyroidism causes marked structural changes in the cauda ductus epididymis and could be adversely affect sperm maturation motility.

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“…Results obtained are in agreement with previous articles that disclosed histological alterations in testes of hypothyroid men [3] and rats [10,14]. The pattern of sperm motility changes during epididymal transit.…”

Section: Discussionsupporting

confidence: 92%