Influence of <i>de qi</i> on the immediate analgesic effect of SP6 acupuncture in patients with primary dysmenorrhoea and <i>cold and dampness stagnation</i>: A multicentre randomised controlled trial

Minyi, Zhao; Zhang, Peng; Li, Jing; Wang, Linpeng; Zhou, Wei; Wang, Yanxia; She, Yan-Fen; Ma, Liang-Xiao; Wang, Pei; Hu, Nijuan; Cai, Lin; Hu, Songhua; Wu, Guiwen; Wang, Ya-Feng; Sun, Jiangwei; Jiang, Si-zhu; Zhu, Jiang

doi:10.1136/acupmed-2016-011228

Cited by 27 publications

(25 citation statements)

References 15 publications

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“…"Deqi" is a needle response describing how the patients feel when they receive the needle insertion, which is regarded as a uniquely key predictor and an essential role in therapeutic effectiveness of acupuncture for stroke recovery [23]. Until now, there isn't a standard needle sensation assessment scale but all the self-designed scales consist of two parts.…”

Section: Needle Sensation Assessment Scale (Nsas)mentioning

confidence: 99%

Acupuncture for poststroke hemiplegia focusing on bilateral cerebral connections: study protocol for a randomized controlled trial

Jiang

Geng

et al. 2019

Preprint

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Background: Acupuncture is safe and effective for improving the motor function of poststroke hemiplegic patients, but there still exists a certain gap between clinical practice and its neural mechanisms. The cerebral functional reconstruction after unilateral motor pathway injury exhibits a bilateral tendency, however current studies seldom pay attention to it. Hence, based on bilateral cerebral connections, the underlying mechanism of acupuncture in stroke rehabilitation remains research space to date. Methods: This is a single-center, randomized controlled, paralleled neuroimaging trial, with patients, outcome assessors, and data statisticians blinded. Stroke patients with motor dysfunction meeting the inclusion criteria will be randomly assigned (2:1) to receive either true acupoints treatment or sham acupoints treatment (5 sessions per week for 2 weeks). All the patients will receive conventional treatment and rehabilitation. Participants will undergo the neuroimaging scanning before and after the entire acupuncture treatment. The clinical primary outcomes are Fugl-Meyer assessments (FMA) and the National Institutes of Health stroke scales (NIHSS). The secondary outcome is Needle Sensation Assessment Scale (NSAS). The neuroimaing outcomes are voxel-mirrored homotopic connectivity (VMHC), fractional anisotropy (FA) and gray matter volume (GMV). The correlation analysis will be explored between the neuroimage indicators and clinical motor assessments. Discussion: From the perspective of bilateral connection, this trial will investigate the cerebral influence of acupuncture treatment on poststroke patients with motor dysfunction, promoting application of acupuncture in stroke rehabilitation. Trial registration: Chinese Clinical Trials Registry, ChiCTR 1800016263. Registered on 22 May, 2018.

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Section: Needle Sensation Assessment Scale (Nsas)mentioning

confidence: 99%

Acupuncture for poststroke hemiplegia focusing on bilateral cerebral connections: study protocol for a randomized controlled trial

Jiang

Geng

et al. 2019

Preprint

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“…The cognitively induced somatosensation observed in our study corroborates studies that have reported remarkably similar de qi sensation between verum and sham acupuncture with regard to intensity, quality, and somatotopic pattern ( Beissner et al, 2015 ; Lee et al, 2014 ; Salih et al, 2010 ). De qi sensation, the somatosensation elicited by acupuncture stimulation, has been asserted to be a useful predictor of successful acupuncture treatment ( Spaeth et al, 2013 ; Zhao et al, 2017 ). Furthermore, cognitive factors in acupuncture stimulation, such as a patient's perception and expectations, can influence acupuncture analgesia ( Vase et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Brain activation during the expectations of sensory experience for cutaneous electrical stimulation

Jung

Ryu

Park

et al. 2018

NeuroImage: Clinical

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The brain actively interprets sensory inputs by integrating top-down and bottom-up information. Humans can make inferences on somatosensation based on prior experiences and expectations even without the actual stimulation. We used functional magnetic resonance imaging to investigate the neural substrates of the expectations of the sensory experience of cutaneous electrical stimulation on acupoint without actual stimuli. This study included 22 participants who wore sticker-type electrodes attached on three different acupoints on different body regions: CV17 (chest), CV23 (chin), and left PC6 (arm). Participants evaluated de qi sensations after they expected electrical stimulation on those points in random order without actual stimulation. All stimuli were presented with corresponding visual information of the stimulation sites. The control condition included the same visual information but outside the body. The expectations of cutaneous electrical stimuli without actual stimulation on three acupoints resulted in greater de qi sensation compared to the control condition. Cognitive components of cutaneous electrical stimulation exhibited greater brain activation in the anterior insula, pre-supplementary motor area, and secondary somatosensory area. The expectations of acupuncture stimulation exhibited a distinct experience of somatosensation as well as brain activations in insula and pre-supplementary motor area. Our findings suggest that the sensory experience of the pseudo-cutaneous stimulation may be derived from the predictive role of the salience network in monitoring internal and external body states.

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“…Deqi is a needle response describing how the patients feel when they receive the needle insertion, which is regarded as a unique key predictor and an essential role in the therapeutic effectiveness of acupuncture for stroke recovery. 31 The self-designed NSAS we adopt has been tested in our previous studies, 32 which includes Deqi features (sourness, numbness, tingling, aching and propagated feeling along the meridians) and rating of Deqi. Patients will describe the intensity of needle sensation by Visual Analogue Scale (0 stands for none, 10 stands for unbearable).…”

Section: Needle Sensation Assessmentmentioning

confidence: 99%

Acupuncture for poststroke hemiplegia focusing on cerebral bilateral connections: study protocol for a randomised controlled neuroimaging trial

Jiang

Geng

et al. 2020

BMJ Open

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IntroductionAcupuncture is safe and effective for improving the motor function of poststroke hemiplegic patients, but there still exists a certain gap between clinical practice and understanding its neural mechanisms. The cerebral functional reconstruction after unilateral motor pathway injury exhibits a bilateral tendency, however current studies seldom pay attention to it. Hence, based on cerebral bilateral connections, the underlying mechanism of acupuncture in stroke rehabilitation remains an area for further research. The results of this study will increase our understanding of acupuncture-induced motor recovery in patients who had suffered a stroke and demonstrate the differences in brain response and clinical assessments.Methods and analysisThis is a single-centre, randomised controlled, paralleled neuroimaging trial, with patients and outcome assessors blinded. Thirty patients who had a stroke with motor dysfunction meeting the inclusion criteria will be randomly assigned (2:1) to receive either 10 sessions true or sham acupoints treatments (five sessions per week for 2 weeks). All the participants will receive conventional standard medical care and rehabilitation. Motor function assessments and neuroimaging scanning will be conducted before and after the entire acupuncture treatment. The clinical and neuroimaging data will be analysed, respectively. The voxel-mirrored homotopic connectivity will be the primary outcome and the primary effect indicator. The secondary outcomes comprise clinical evaluations and neuroimaging assessments, which include Fugl-Meyer Assessment, the National Institutes of Health Stroke Scale, fractional anisotropy and gray matter volume. The Needle Sensation Assessment Scale is an additional outcome. The correlation analysis will be explored between the neuroimaging indicators, clinical motor assessments and needle sensation.Ethics and disseminationThe protocol has been approved by the ethics committee of Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine (DZMEC-KY-2018-04). The results of the neuroimaging trial will be disseminated through peer-reviewed publications and conferences.Trial registration numberChinese Clinical Trials Registry (ChiCTR 1800016263).

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Influence of de qi on the immediate analgesic effect of SP6 acupuncture in patients with primary dysmenorrhoea and cold and dampness stagnation: A multicentre randomised controlled trial

Abstract: Objective The aim of this multicentre randomised controlled trial was to investigate the contribution of de qi to the immediate analgesic effect of acupuncture in patients with primary dysmenorrhoea and the specific traditional Chinese medicine diagnosis cold and dampness stagnation.

Cited by 27 publications

References 15 publications

Acupuncture for poststroke hemiplegia focusing on bilateral cerebral connections: study protocol for a randomized controlled trial

Acupuncture for poststroke hemiplegia focusing on bilateral cerebral connections: study protocol for a randomized controlled trial

Brain activation during the expectations of sensory experience for cutaneous electrical stimulation

Acupuncture for poststroke hemiplegia focusing on cerebral bilateral connections: study protocol for a randomised controlled neuroimaging trial

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