Influence of <i>N</i>‐acylhomoserine lactonase silver nanoparticles on the quorum sensing system of <i>Helicobacter pylori</i>: A potential strategy to combat biofilm formation

Gopalakrishnan, Vinoj; Esakkirajan, Masanam; Ramkumar, Vijayan Sri; Baskaraligam, Vaseeharan; Selvaraj, Gopinath

doi:10.1002/jobm.201900537

Cited by 24 publications

(17 citation statements)

References 53 publications

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“…Hence, proteins are one of the attractive targets for finding new antimicrobial therapies. To date, it has been shown that AuNPs and AgNPs, along with their respective ions, interact with several structural proteins, membrane proteins and several enzymes [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. In an experimental and molecular docking study, Shah et al evidenced the diverse action of AgNPs on various proteins of Pseudomonas aeruginosa [ 32 ].…”

Section: Interaction Of Gold and Silver Nanoparticles With Biofilmmentioning

confidence: 99%

Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance

Joshi

Singh

Mijaković

2020

IJMS

184

113

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Many bacteria have the capability to form a three-dimensional, strongly adherent network called ‘biofilm’. Biofilms provide adherence, resourcing nutrients and offer protection to bacterial cells. They are involved in pathogenesis, disease progression and resistance to almost all classical antibiotics. The need for new antimicrobial therapies has led to exploring applications of gold and silver nanoparticles against bacterial biofilms. These nanoparticles and their respective ions exert antimicrobial action by damaging the biofilm structure, biofilm components and hampering bacterial metabolism via various mechanisms. While exerting the antimicrobial activity, these nanoparticles approach the biofilm, penetrate it, migrate internally and interact with key components of biofilm such as polysaccharides, proteins, nucleic acids and lipids via electrostatic, hydrophobic, hydrogen-bonding, Van der Waals and ionic interactions. Few bacterial biofilms also show resistance to these nanoparticles through similar interactions. The nature of these interactions and overall antimicrobial effect depend on the physicochemical properties of biofilm and nanoparticles. Hence, study of these interactions and participating molecular players is of prime importance, with which one can modulate properties of nanoparticles to get maximal antibacterial effects against a wide spectrum of bacterial pathogens. This article provides a comprehensive review of research specifically directed to understand the molecular interactions of gold and silver nanoparticles with various bacterial biofilms.

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Section: Interaction Of Gold and Silver Nanoparticles With Biofilmmentioning

confidence: 99%

Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance

Joshi

Singh

Mijaković

2020

IJMS

184

113

View full text Add to dashboard Cite

show abstract

“…In the vast majority of the studies, spherical silver nanoparticles were used, obtained from different extracts, having various sizes: A. priceps , 5–30 nm [ 125 ]; S. xanthocarpum , 4–18 nm [ 32 , 126 ]; T. vernicifluum , 4–20 nm [ 127 ]; C. longa [ 128 ] and A. nilotica , 22–66 nm [ 124 ]; P. putida , 6–16 nm [ 35 ]; A. calamus , 5–60 nm [ 129 ]; A. nilotica , 22–55 nm [ 130 ]. The most common effect on the bacterial colonies was inhibition of growth, which was presented in six of the papers [ 124 , 125 , 127 , 128 , 131 , 132 , 133 , 134 ], followed by activation of reactive oxygen species production [ 130 , 132 ], inactivation of H. pylori urease [ 131 , 135 ], bacterial DNA fragmentation and consecutive loss of viability [ 130 ], damage to the bacterial cellular membrane [ 132 ], and activation of antioxidant activity [ 136 ].…”

Section: The Antibacterial Mechanism Of Silver Nanoparticles: An Exte...mentioning

confidence: 99%

Helicobacter Pylori-Induced Gastric Infections: From Pathogenesis to Novel Therapeutic Approaches Using Silver Nanoparticles

et al. 2022

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Helicobacter pylori is the first formally recognized bacterial carcinogen and the most important single digestive pathogen responsible for the induction of gastroduodenal diseases such as gastritis, peptic ulcer, and, finally, gastric neoplasia. The recently reported high rates of antimicrobial drug resistance hamper the current therapies of H. pylori, with therapeutic failure reaching up to 40% of patients. In this context, new treatment options and strategies are urgently needed, but the successful development of these new therapeutic tools is conditioned by the understanding of the high adaptability of H. pylori to the gastric acidic environment and the complex pathogenic mechanism. Due to several advantages, including good antibacterial efficiency, possible targeted delivery, and long tissular persistence, silver nanoparticles (AgNPs) offer the opportunity of exploring new strategies to improve the H. pylori therapy. A new paradigm in the therapy of H. pylori gastric infections using AgNPs has the potential to overcome the current medical limitations imposed by the H. pylori drug resistance, which is reported for most of the current organic antibiotics employed in the classical therapies. This manuscript provides an extensive overview of the pathology of H. pylori-induced gastritis, gastric cancer, and extradigestive diseases and highlights the possible benefits and limitations of employing AgNPs in the therapeutic strategies against H. pylori infections.

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“…clarify that N-acyl homoserine lactonase-stabilized silver NPs inhibit quorum sensing (QS) by degradation, thereby reducing biofilm formation and improving the effect treatment. ( 55 ). Niaz prepared a nanodelivery system that is composed of a protein/polysaccharide core-shell crown.…”

Section: H Pylori and Nanomaterialsmentioning

confidence: 99%

New Advances in Nano-Drug Delivery Systems: Helicobacter pylori and Gastric Cancer

Zhu

Wang

et al. 2022

Front. Oncol.

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With the development of materials science and biomedicine, the application of nanomaterials in the medical field is further promoted. In the process of the diagnosis and treatment of diseases, a variety of drugs need to be used. It is an ideal state to make these drugs arrive at a specific location at a specific time and release at a specific speed, which can improve the bioavailability of drugs and reduce the adverse effects of drugs on normal tissues. Traditional drug delivery methods such as tablets, capsules, syrups, and ointments have certain limitations. The emergence of a new nano-drug delivery system further improves the accuracy of drug delivery and the efficacy of drugs. It is well known that the development of the cancer of the stomach is the most serious consequence for the infection of Helicobacter pylori. For the patients who are suffering from gastric cancer, the treatments are mainly surgery, chemotherapy, targeted and immune therapy, and other comprehensive treatments. Although great progress has been made, the diagnosis and prognosis of gastric cancer are still poor with patients usually diagnosed with cancer at an advanced stage. Current treatments are of limited benefits for patients, resulting in a poor 5-year survival rate. Nanomaterials may play a critical role in early diagnosis. A nano-drug delivery system can significantly improve the chemotherapy, targeted therapy, and immunotherapy of advanced gastric cancer, reduce the side effects of the original treatment plan and provide patients with better benefits. It is a promising treatment for gastric cancer. This article introduces the application of nanomaterials in the diagnosis and treatment of H. pylori and gastric cancer.

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Influence of N‐acylhomoserine lactonase silver nanoparticles on the quorum sensing system of Helicobacter pylori: A potential strategy to combat biofilm formation

Cited by 24 publications

References 53 publications

Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance

Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance

Helicobacter Pylori-Induced Gastric Infections: From Pathogenesis to Novel Therapeutic Approaches Using Silver Nanoparticles

New Advances in Nano-Drug Delivery Systems: Helicobacter pylori and Gastric Cancer

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