Influence of<i>Salvia miltiorrhizae</i>on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Zhang, Xiping; Zhang, Jie; Ye, Shu-Yun; Qili, Wang; Gao, Feng; Pan, Yan

doi:10.1155/2009/675195

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…In animal studies, Salvia miltiorrhiza Bunge extracts have appeared to inhibit the process of liver fibrosis and improve liver function by reducing the nonfunctioning fibers in the liver. For people who have chronic hepatitis or excessive consumption of alcohol, Salvia miltiorrhiza Bunge is recommended for protecting their liver function [ 143 ].…”

Section: Recent Research On the Roles Of Herbs And Phytochemicals mentioning

confidence: 99%

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Hong

Tan

et al. 2015

IJMS

148

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Chronic liver dysfunction or injury is a serious health problem worldwide. Chronic liver disease involves a wide range of liver pathologies that include fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The efficiency of current synthetic agents in treating chronic liver disease is not satisfactory and they have undesirable side effects. Thereby, numerous medicinal herbs and phytochemicals have been investigated as complementary and alternative treatments for chronic liver diseases. Since some herbal products have already been used for the management of liver diseases in some countries or regions, a systematic review on these herbal medicines for chronic liver disease is urgently needed. Herein, we conducted a review describing the potential role, pharmacological studies and molecular mechanisms of several commonly used medicinal herbs and phytochemicals for chronic liver diseases treatment. Their potential toxicity and side effects were also discussed. Several herbal formulae and their biological effects in chronic liver disease treatment as well as the underlying molecular mechanisms are also summarized in this paper. This review article is a comprehensive and systematic analysis of our current knowledge of the conventional medicinal herbs and phytochemicals in treating chronic liver diseases and on the potential pitfalls which need to be addressed in future study.

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Section: Recent Research On the Roles Of Herbs And Phytochemicals mentioning

confidence: 99%

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Hong

Tan

et al. 2015

IJMS

148

View full text Add to dashboard Cite

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Effects of Salvia Miltiorrhizae on the Kidney of Rats With Severe Acute Pancreatitis and Obstrutive Jaundice

Ren¹,

Zhang²,

Xiao-wen³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Severe acute pancreatitis (SAP) and obstructive jaundice (OJ) are frequent recurring diseases that bring about huge threat to human health. Some reports have demonstrated that Salviae miltiorrhizae can protect multiple organs of SAP and OJ model animals or patients, but their related mechanisms were not clear. In this study, we observed the effects of Salvia miltiorrhizae injection on apoptosis and NF-κB expression in kidney and explored the protective effect and mechanism of Salvia miltiorrhizae on the kidney of SAP or OJ rats. The results obtained will provide a theoretical basis for clinical application of Salvia miltiorrhizae. Material and Methods: A total of 288 rats were used for SAP - and OJ-associated experiments. The mortality rates of rats, the contents of serum BUN and CREA, the expression levels of Bax, NF-κB proteins and the apoptosis index were observed, respectively. Results: The pathological changes in the kidney of SAP or OJ rats in treated group were mitigated to varying degrees. At 6 and 12 hours after operation in SAP rats or on 21 and 28 days after operation in OJ rats, the contents of serum CREA in treated group were significantly lower than those in model control group; At 3 and 6 hours after operation, the staining intensity of Bax protein of kidney in treated group was significantly lower than that in model control group; on 14 days after operation, the apoptosis index in the kidney of OJ rats in treated group was significantly lower than that in model control group. Conclusion: Salvia miltiorrhizae can exert protective effects on the kidney of SAP and OJ rats.

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Influence ofSalvia miltiorrhizaeon the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Cited by 2 publications

References 29 publications

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Effects of Salvia Miltiorrhizae on the Kidney of Rats With Severe Acute Pancreatitis and Obstrutive Jaundice

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