Influence of IGF-I serum concentration on muscular regeneration capacity in patients with sarcopenia

Jarmusch, Stefanie; Baber, Lisa; Bidlingmaier, Martin; Ferrari, Uta; Hofmeister, Fabian; Hintze, Stefan; Mehaffey, Stefan; Meinke, Peter; Neuerburg, Carl; Schöser, Benedikt; Tanganelli, Fabiana; Drey, Michael

doi:10.1186/s12891-021-04699-3

Cited by 14 publications

(9 citation statements)

References 55 publications

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“…Lower levels of insulin-like growth factor-1 expression in sarcopenia have been linked to muscle denervation, as well as poor neuronal regeneration. 22 This relationship carries clinical implications. Because DPN is a significant risk factor for foot ulcers, lower limb amputation and falls, current clinical practice suggests early screening for DPN in all patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Association between diabetic peripheral neuropathy and sarcopenia: A systematic review and meta‐analysis

Wannarong

Sukpornchairak

Naweera³

et al. 2022

Geriatrics Gerontology Int

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Aim The present study comprehensively investigated the relationship between diabetic peripheral neuropathy (DPN) and sarcopenia by identifying all eligible studies and summarizing their results. Methods Records were identified through MEDLINE and EMBASE database searching from inception to March 9, 2022. We included all cross‐sectional studies investigating the association between DPN and sarcopenia among patients with diabetes. Data from eligible studies, including point estimates and standard errors, were pooled together using the generic inverse variance method. Results Of 2989 retrieved articles, five studies met the inclusion criteria and were allowed for meta‐analysis. The pooled analysis found a significant association between DPN and sarcopenia with the pooled odds ratio of 1.62 (95% confidence interval: 1.30–2.02; I2 0%). The funnel plot was relatively symmetric and was not suggestive of the presence of publication bias. Conclusions The current study discovered a significant association between DPN and sarcopenia in patients with diabetes. However, given summarized data from cross‐sectional studies, the temporality between DPN and sarcopenia could not be established. Geriatr Gerontol Int 2022; 22: 785–789.

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Section: Discussionmentioning

confidence: 99%

Association between diabetic peripheral neuropathy and sarcopenia: A systematic review and meta‐analysis

Wannarong

Sukpornchairak

Naweera³

et al. 2022

Geriatrics Gerontology Int

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“…This method correlates well with MRI findings of whole-body muscle mass [ 84 ] and requires additional enhancement to be widely applied in the clinical setting. The incorporation of additional clinical measurements will also be important, such as ones borrowed from neuromuscular fields, including the number (MUNIX) and size (MUSIX) of motor neurons by electromyography which correlates with the degree of sarcopenia [ 85 , 86 ].…”

Section: Discussionmentioning

confidence: 99%

Gene Ontology (GO)-Driven Inference of Candidate Proteomic Markers Associated with Muscle Atrophy Conditions

et al. 2022

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Skeletal muscle homeostasis is essential for the maintenance of a healthy and active lifestyle. Imbalance in muscle homeostasis has significant consequences such as atrophy, loss of muscle mass, and progressive loss of functions. Aging-related muscle wasting, sarcopenia, and atrophy as a consequence of disease, such as cachexia, reduce the quality of life, increase morbidity and result in an overall poor prognosis. Investigating the muscle proteome related to muscle atrophy diseases has a great potential for diagnostic medicine to identify (i) potential protein biomarkers, and (ii) biological processes and functions common or unique to muscle wasting, cachexia, sarcopenia, and aging alone. We conducted a meta-analysis using gene ontology (GO) analysis of 24 human proteomic studies using tissue samples (skeletal muscle and adipose biopsies) and/or biofluids (serum, plasma, urine). Whilst there were few similarities in protein directionality across studies, biological processes common to conditions were identified. Here we demonstrate that the GO analysis of published human proteomics data can identify processes not revealed by single studies. We recommend the integration of proteomics data from tissue samples and biofluids to yield a comprehensive overview of the human skeletal muscle proteome. This will facilitate the identification of biomarkers and potential pathways of muscle-wasting conditions for use in clinics.

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“…After eccentric exercise, the myofiber and the satellite cells upregulate the gene expression of IGF-I, resulting in greater production of IGF-I between 24–72 h post-exercise [ 38 ]. Furthermore, endocrine and autocrine as well as paracrine IGF mechanisms have been shown to mediate muscle development and repair, an early response critical in the regenerative process [ 39 , 40 , 41 ]. In line with this, our results revealed that for both treatments IGF-I in reached its peak value following 48 h post-exercise ( Figure 3 C).…”

Section: Discussionmentioning

confidence: 99%

Astragalosides Supplementation Enhances Intrinsic Muscle Repair Capacity Following Eccentric Exercise-Induced Injury

et al. 2022

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Astragalosides have been shown to enhance endurance exercise capacity in vivo and promote muscular hypertrophy in vitro. However, it remains unknown whether astragalosides supplementation can alter inflammatory response and enhance muscle recovery after damage in humans. We therefore aimed to evaluate the effect of astragalosides supplementation on muscle’s intrinsic capacity to regenerate and repair itself after exercise-induced damage. Using a randomized double-blind placebo-controlled cross-over design, eleven male participants underwent 7 days of astragalosides supplementation (in total containing 4 mg of astragalosides per day) or a placebo control, following an eccentric exercise protocol. Serum blood samples and variables related to muscle function were collected prior to and immediately following the muscle damage protocol and also at 2 h, and 1, 2, 3, 5, and 7 days of the recovery period, to assess the pro-inflammatory cytokine response, the secretion of muscle regenerative factors, and muscular strength. Astragalosides supplementation reduced biomarkers of skeletal muscle damage (serum CK, LDH, and Mb), when compared to the placebo, at 1, 2, and 3 days following the muscle damage protocol. Astragalosides supplementation suppressed the secretion of IL-6 and TNF-α, whilst increasing the release of IGF-1 during the initial stages of muscle recovery. Furthermore, following astragaloside supplementation, muscular strength returned to baseline 2 days earlier than the placebo. Astragalosides supplementation shortens the duration of inflammation, enhances the regeneration process and restores muscle strength following eccentric exercise-induced injury.

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Influence of IGF-I serum concentration on muscular regeneration capacity in patients with sarcopenia

Cited by 14 publications

References 55 publications

Association between diabetic peripheral neuropathy and sarcopenia: A systematic review and meta‐analysis

Association between diabetic peripheral neuropathy and sarcopenia: A systematic review and meta‐analysis

Gene Ontology (GO)-Driven Inference of Candidate Proteomic Markers Associated with Muscle Atrophy Conditions

Astragalosides Supplementation Enhances Intrinsic Muscle Repair Capacity Following Eccentric Exercise-Induced Injury

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