Influence of Immunological Dissimilarity of Mother and Fœtus on Size of Placenta in Mice

Billington, W. D.

doi:10.1038/202317a0

Cited by 155 publications

(60 citation statements)

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“…The overall fertility of the crosses used in this study was similar to that observed in previous investigations (Liu, 1953a;Dawson, 1965 (Liu, 1953b Billington (1964) and James (1965James ( , 1967 Strong histo-incompatibility between P. polionotus females and the foetal PM hybrid could also account for pre-natal mortality in this cross. Liu (1953b) showed that most of the reduction in litter size in this cross is due to foetal death and résorption in the latter half of pregnancy and suggested such a mechanism.…”

Section: Introductionsupporting

confidence: 88%

“…However, inheritance data (Dawson, 1962) did not support this concept; and the only known erythrocytic antigen differences in Peromyscus did not seem to result in foetal-maternal incompati¬ bility (Rasmussen, 1965). Interest in the antigen hypothesis was revived by studies of strain crosses in the laboratory mouse, Mus musculus, performed by Billington (1964) and James (1965,1967 Placental decidual surface areas were calculated from the greatest and least diameters by the approximation:…”

Section: Introductionmentioning

confidence: 99%

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Foetal and Placental Size in a Peromyscus Species Cross

Rogers¹,

Dawson²

1970

Reproduction

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Summary. Near-term conceptuses of Peromyscus maniculatus, P. polionotus and their reciprocal hybrids were collected. Foetal weight and crown\p=m-\ rump length were ascertained, as were placental weight and decidual surface area. No significant differences in these measurements were found when the parent species were compared, but the reciprocal hybrids differed significantly from each other and from the parent types in means for these characters. Placentae from reciprocal hybrids showed more than a five-fold difference in weight. They also differed markedly in histological structure. Foetal weight was positively correlated with placental weight in all crosses. These findings are discussed with reference to immunological factors in placentation.

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Section: Introductionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Foetal and Placental Size in a Peromyscus Species Cross

Rogers¹,

Dawson²

1970

Reproduction

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“…Since then, numerous experiments have demonstrated that maternal-fetal MHC incompatibility is not deleterious [237,239]. In many cases this dissimilarity is beneficiary to embryo development [240][241][242]. However the mechanisms responsible for both the survival of fetal allograft and for promotion of MHC incompatible embryo are still unclear.…”

Section: Mother and Fetuses Dissimilaritymentioning

confidence: 99%

The Role of the Immune System in Behavioral Strategies of Reproduction

Мошкин

Gerlinskaya

Evsikov

2000

Journal of Reproduction and Development

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Abstract. Since both reproduction and immunocompetence are costly, the negative reciprocal relationships between these functions were found in many species. Due to reproductive immunosuppression, some fraction of seasonally breeding populations of small mammals reproduces in the first breeding season, while others reproduce in the next one. Elevation of breeding efforts under the increased risk of mortality and the reproductive delay until recovery are the polar variants of mating behavior of parasitized individuals. However the parasite-induced changes of odor, visual or acoustic signals limit the mating success of the infected hosts. The direct influence of the immune system, regularly activated by infections, to chemicals signals can be answer to the question: why these signals are honest? Decrease of a strange infection risk by kin breeding can be a satisfactory strategy of an isolated population. Nevertheless, many species follow the inbreeding avoidance strategy, where the major histocompatibility complex (MHC) genes play key role in kin recognition. The advantage of MHC heterozygosity was found at the all steps of the breeding cycle; including mating choice, fertilization, pre-and postnatal development. So, the relationships between immune system and neuroendocrine regulation of behavior give proximate explanations of the evolutionary stable strategies of breeding behavior.

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“…7,8 This is evidenced by increased risk in women with some autoimmune diseases, including antiphospholipid syndrome. 9 In addition, maternal-paternal immunogenetic relationships appear to influence pregnancy outcomes, 10,11 with a beneficial effect of disparity in human leukocyte antigen (HLA) genes in successful pregnancies, and a number of studies showing that excess HLA-sharing in a couple may be a risk factor for RM. [12][13][14][15] With this in mind, and extrapolating from the transplant literature in which some data suggest benefit of pre-transplant transfusion, 16 various immunotherapies have been considered for RM, aiming to modulate maternal recognition of the pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Microchimerism in recurrent miscarriage

et al. 2014

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Maternal-fetal cell exchange during pregnancy results in acquisition of microchimerism, which can durably persist in both recipients. Naturally acquired microchimerism may impact maternal-fetal interaction in pregnancy. We conducted studies to ask whether microchimerism that a woman acquired from her own mother is detectable before or during pregnancy in women with recurrent miscarriage. Fetal microchimerism was also assayed. Women with primary idiopathic recurrent miscarriage (n523) and controls (n531) were studied. Genotyping was conducted for probands, their mothers and the fetus, a non-shared polymorphism identified and quantitative polymerase chain reaction performed to measure microchimerismin peripheral blood mononuclear cells. Preconception comparisons were made between recurrent miscarriage subjects and controls, using logistic regression and Wilcoxon rank sum. Longitudinal microchimerism in subsequent pregnancies of recurrent miscarriage subjects was described. There was a trend toward lower preconception detection of microchimerism in recurrent miscarriage versus controls, 6% vs. 19% (1/16 vs. 6/31, P50.2). During pregnancy, 3/11 (27%) of recurrent miscarriage subjects who went on to have a birth had detection of microchimerism from their own mother, whereas neither of two subjects who went on to miscarry had detection (0/2). This initial data suggest that microchimerism from a woman's own mother, while detectable in women with recurrent miscarriage, may differ from controls and according to subsequent pregnancy outcome. Further studies are needed to determine the cell types, quantities and any potential functional role of microchimerism in recurrent miscarriage.

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Influence of Immunological Dissimilarity of Mother and Fœtus on Size of Placenta in Mice

Cited by 155 publications

References 0 publications

Foetal and Placental Size in a Peromyscus Species Cross

Foetal and Placental Size in a Peromyscus Species Cross

The Role of the Immune System in Behavioral Strategies of Reproduction

Microchimerism in recurrent miscarriage

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