Influence of incisor tooth development on osteoclast abundance and generation in the foetal rat mandible

Savostin-Asling, I

doi:10.1016/0003-9969(74)90167-8

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Although scarce, there are some other reports which relate resorption of Meckel's cartilage to the nearby presence of teeth. Savostin-Asling (1972 and Savostin-Asling and Asling (1973) found not only a spatial relationship between incisor development in rats and resorption of Meckel's cartilage as part of a ring of erosion around the developing incisor, but also a relation to the generation of multinucleated cells in the loose intervening tissues. Most interestingly, in the 'incisor absent' (ia) rat strain, bone and Meckel's cartilage resorption is delayed (Bhaskar et al, 1953).…”

Section: Role Of Tooth Germs In Bone and Cartilage Resorptionmentioning

confidence: 96%

“…Most interestingly, in the 'incisor absent' (ia) rat strain, bone and Meckel's cartilage resorption is delayed (Bhaskar et al, 1953). In the normal rat, the midpoint of erosion at day 19 is at the level where the tooth attains its full girth although the outline of the tooth is surrounded by a broad zone of loose connective tissue (Savostin-Asling, 1974). In the latter study, Savostin-Asling found a quantitative relationship between tooth dimensions and osteoclast abundance except in that area of the tooth bud not completely encircled by bone.…”

Section: Role Of Tooth Germs In Bone and Cartilage Resorptionmentioning

confidence: 99%

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Bone and cartilage resorption in relation to tooth development in the anterior part of the mandible in cichlid fish: A light and TEM study

Huysseune

Sire

1992

Anat. Rec.

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This paper presents ultrastructural features of the contact region between particular tooth germs and Meckel's cartilage prior to, during, and after initial resorption of the perichondral bone and of the cartilage in the cichlids Hemichromis bimaculatus and Astatotilapia burtoni. Imminent resorption opposite such teeth is announced by the presence, in this region, of a particular cell type, considered to be a stage in the cytodifferentiation of osteoclasts. Slightly later, an osteoclast with typical ruffled border is seen to open a fenestra in the perichondral bone which surrounds Meckel's cartilage. Although the action of the osteoclast is directed primarily towards the bone, it may also affect, to a much lesser extent, the underlying uncalcified cartilage. Typically, fibroblast-like cells invade the resorption cavity along with the osteoclast; the tooth germ soon follows. Capillaries are seen to invade the cartilage only at a later stage when a large cavity has been established. It is proposed that the fibroblast-like cells may have a dual function: degradation of cartilage and deposition of new bone. Although these processes are normally limited to the area surrounding tooth germs at specific loci, tooth germs in other positions may sometimes be seen invade the cartilage. They do so either passively, because of the existence of such a cavity, or as a result of their own resorption-inducing activity. Whatever the mechanism, attachment bone is being deposited within the erosion cavity and on the surface of the exposed perichondral bone. The stimuli possibly eliciting resorption of Meckel's cartilage are discussed. It is hypothesized that pressure exerted by the growing tooth germ may stimulate the osteoblasts covering the bone surface and, in this way, provoke osteoclastic bone resorption.

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Section: Role Of Tooth Germs In Bone and Cartilage Resorptionmentioning

confidence: 96%

Section: Role Of Tooth Germs In Bone and Cartilage Resorptionmentioning

confidence: 99%

Bone and cartilage resorption in relation to tooth development in the anterior part of the mandible in cichlid fish: A light and TEM study

Huysseune

Sire

1992

Anat. Rec.

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“…Osteoclasts resorbing bone around developing incisors in fetal rat mandibles have been observed (Savostin-Asling 1974) and odontoclasts (osteoclasts) are known to resorb to dentine in human deciduous teeth (Furseth 1968;Sasaki etal. Osteoclasts resorbing bone around developing incisors in fetal rat mandibles have been observed (Savostin-Asling 1974) and odontoclasts (osteoclasts) are known to resorb to dentine in human deciduous teeth (Furseth 1968;Sasaki etal.…”

Section: Osteoclastsmentioning

confidence: 99%

Structure and origin of the tooth pedicel (the so-called bone of attachment) and dental-ridge bone in the mandibles of the sea breams Acanthopagrus australis, Pagrus auratus and Rhabdosargus sarba (Sparidae, Perciformes, Teleostei)

1994

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Scanning electron and light microscopy were used to show that the pedicels of fish teeth (the so-called "bones of attachment") consist of three types of dentine that lie concentrically around a pulp cavity lined with typical odontoblasts with cytoplasmic processes in dentinal tubules. Circumpulpal canalar dentine forms on a thin layer of orthodentine that is encased in mantle dentine. Canalar dentine is a new name given to a dentine that is similar to vasodentine in canal arrangement, but not apparently in canal content. An inner series of wide, radial canals and an outer series of highly-branched thin canals of two diameters are inhabited by a population of cells, the osteodentocytes, and collagen fibril bundles. The flat, oval osteodentocytes appear to be quiescent cells, lying on the sides of the tubules and covered by a sheath. Plump, intensely metachromatic osteodentocytes appear to be more synthetically active. The canals and the osteodentocytes originate from blood capillaries enclosed in the predentine during dentinogenesis. New teeth begin within the small cavities present in spongy bone that were enlarged by multinucleated osteoclasts during tooth growth. Pedicel formation is initiated by the extension of the crown mantle dentine, forming the outer layer of the crimped ligament and outlining the future length and curvature of the pedicel. Central and inner ligament zones are subsequently formed as orthodentine is secreted in both crown and pedicel, and canalar dentine in the pedicel. Spongy bone osteogenesis begins during stage 1 of pedicel formation with the aggregation of osteoblasts and blood capillaries in the bone cavities and in the dermis between the pedicels. Loose fibrillar osteoid condenses into incomplete thin trabeculae bordered by intensely metachromatic osteoblasts. Osteoblasts become enclosed in the developing trabeculae that thicken to give mature spongy bone with osteocytes throughout. We conclude that the pedicels are the true bases of teeth, that the dental ridge is formed from pedicels and spongy bone, and that sea bream spongy bone is cellular. The term "bone of attachment" is inappropriate for the pedicel. It can be used for the spongy bone between the compact bone of the jaw and between adjacent pedicel.

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“…Observations of osteociasts suggest that only later is there a proliferation of precursor cells leading to an increase in osteoclast numbers (Bingham & Owen 1969). The origin of osteociasts has been discussed by Fischman & Hay 1962, Jee & Nolan 1963, Gothlin & Ericsson 1973, Savostin-Asling 1974, Addison 1976 but as yet there is no conclusive evidence for an exact origin. In a recent autoradiographic study concluded that osteoprogenitor cells are probably not the source of osteociasts.…”

Section: Discussionmentioning

confidence: 99%

The effect of parathyroid hormone on the numbers of nuclei in feline odontoclasts in vivo

Addison

1980

J of Periodontal Research

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Odontoclasts exhibit varying numbers of nuclei. The purpose of the present study was to determine the effect of a low dose (4 USP units per 100 g. body weight) of parathyroid hormone extract (PTE) in vivo on the numbers of nuclei in whole feline odontoclasts. Odontoclasts were recovered in smear type preparations from the resorbing primary teeth of 12 kittens aged approximately 18 weeks. Four kittens had received PTE intravenously one hour prior to sacrifice, four six hours previously, and four were controls. The fresh smears were allowed to dry and subjected to dehydrogenase enzyme histochemical reactions. The unstained odontoclast nuclei contrasted with the stained cytoplasm and were counted at a magnification of × 125. The three groups had similar distribution patterns of nuclei per cell but progressive increases in the mean and median numbers of nuclei per cell were found following PTE treatment. The mean in control animals was 7.0 S.E. ± 0.12 and in the PTE 1 hour and PTE 6 hours groups was 8.0 S.E. ± 0.12 and 8.9 S.E. ± 0.12 respectively. The median values were 5.5, 6.6 and 7.3 respectively. The differences between both the control and PTE 1 hour, and between the PTE 1 hour and PTE 6 hours groups were statistically significant (p < 0.001). This rapid increase in the numbers of nuclei in odontoclasts after PTE treatment has not been reported previously.

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Influence of incisor tooth development on osteoclast abundance and generation in the foetal rat mandible

Cited by 7 publications

References 17 publications

Bone and cartilage resorption in relation to tooth development in the anterior part of the mandible in cichlid fish: A light and TEM study

Bone and cartilage resorption in relation to tooth development in the anterior part of the mandible in cichlid fish: A light and TEM study

Structure and origin of the tooth pedicel (the so-called bone of attachment) and dental-ridge bone in the mandibles of the sea breams Acanthopagrus australis, Pagrus auratus and Rhabdosargus sarba (Sparidae, Perciformes, Teleostei)

The effect of parathyroid hormone on the numbers of nuclei in feline odontoclasts in vivo

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