Influence of infections on the quality of general movements in premature infants

Skworc, Aneta; Marciniak, Sylwia; Sławska, Helena

doi:10.1016/j.earlhumdev.2020.105118

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…When the functional components of one system deviate from the norm, it leads to failure and changes in the other system, forming a vicious loop. Cytokines are the connecting links necessary for adaptation, regulation of defence mechanisms, and they also support homeostasis of the newborn's body [17]. When studying the levels of proinflammatory (IL1β) and antiinflammatory (IL10) cytokines in the blood serum of newborns with normal weight and newborns weighing less than 2.500 g, a significant difference in their indicators between the groups was established.…”

Section: Resultsmentioning

confidence: 99%

RETRACTED ARTICLE: The levels of pro- and anti-inflammatory cytokines in premature infants with perinatal infections

et al. 2021

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Intrauterine infections are an urgent problem of modern neonatology. One of the causes of intrauterine infective foetal lesions is physiological immunosuppression. The purpose of this study is to investigate the cytokine status in newborns infected with perinatal infections, depending on their body weight. The study examined 145 newborns. Taking into account their body weight, they were divided into 2 groups: main and secondary. The study was conducted in the immunological laboratory of the Medical Centre of Marat Ospanov West Kazakhstan Medical University in the city of Aktobe, with the determination of the level of IgM and IgG to the herpes simplex virus (HSV) types 1, 2, cytomegalovirus (CMV), and chlamydia using the MULTISKANASCENT analyser with the "Chemo" T system. The main results of this study are the predominance of the anti-inflammatory component in both normal weight and underweight infants, which is evidence of the Th-cell-mediated immune response prevalence. The applied value of this study lies in the possibility of applying its results in practice to obtain effective methods to counteract the occurrence and development of intrauterine infections.

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Section: Resultsmentioning

confidence: 99%

RETRACTED ARTICLE: The levels of pro- and anti-inflammatory cytokines in premature infants with perinatal infections

et al. 2021

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“…In contrast to our study, their findings revealed a direct relationship between GMs and the occurrence of infections, particularly, a higher frequency of poor repertoire patterns during the first 14 days of life. The authors concluded that it is essential to monitor the PT population with a history of infections, emphasizing the importance of understanding their long-term neurodevelopment [29].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between General Movements and Risk Factors in Moderate-Late Preterm Infants: A Prospective Cohort Study

Merino-Andrés,

Pérez-Nombela,

Hidalgo-Robles

et al. 2023

JCM

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Introduction: Moderate-late preterm infants constitute the largest segment of preterm births globally. While previously considered to have a low neurological risk, recent research has uncovered an elevated incidence of neurodevelopmental conditions in this group. This study aimed to assess the relationship between the general movement assessment and birth-related risk factor-based tools in moderate-late preterm infants. Methods: A prospective cohort study of 65 moderate-late preterm infants in a neonatal intensive care unit involved the evaluation of general movements, the Nursery Neurobiologic Risk Score, and the Perinatal Risk Inventory. Associations were analyzed using Fisher’s exact test, Spearman’s correlation was used for ordinal variables, and backward stepwise logistic regression was used to identify predictor variables for the assessments. Results: The findings indicated a high prevalence of normal (41%) and poor (52%) repertoire patterns during the writhing period. While no significant associations were found between the three assessments, a slight approximation emerged between dysmorphic traits and patterns (p = 0.053). Furthermore, an extended period of ventilation correlated with a higher likelihood of developing a cramped synchronized pattern and there was a correlation between both risk factor-based tools (p < 0.001). Conclusions: This research enhances our understanding of the early impact on general movement assessments in moderate-late preterm infants. While no clear relationship emerged between general movement assessment and risk factor-based tools, there was a subtle connection noted with dysmorphic traits. A longer ventilation duration was linked to a higher risk of developing cramped synchronized patterns.

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Cerebral oxygenation during immediate fetal-to-neonatal transition and fidgety movements between six to 20 weeks of corrected age: An ancillary study to the COSGOD III trial

Wolfsberger,

Schwaberger,

Urlesberger

et al. 2024

Eur J Pediatr

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Fidgety movements provide early information about a potential development of cerebral palsy in preterm neonates. The aim was to assess differences in the combined outcome of mortality and fidgety movements defined as normal or pathological in very preterm neonates according to the group allocation in the randomised-controlled multicentre COSGOD III trial. Preterm neonates of two centres participating in the COSGOD III trial, whose fidgety movements were assessed as normal or pathological at six to 20 weeks of corrected age, were analysed. In the COSGOD III trial cerebral oxygen saturation (crSO2) was measured by near-infrared spectroscopy (NIRS) during postnatal transition and guided resuscitation in preterm neonates randomised to the NIRS-group, whereby medical support was according routine, as it was also in the control group. Fidgety movements were classified in normal or abnormal/absent at six to 20 weeks of corrected age. Mortality and fidgety movements of preterm neonates allocated to the NIRS-group were compared to the control-group. Normal outcome was defined as survival with normal fidgety movements. One-hundred-seventy-one preterm neonates were included (NIRS-group n = 82; control-group n = 89) with a median gestational age of 29.4 (27.4–30.4) and 28.7 (26.7–31.0) weeks in the NIRS-group and the control-group, respectively. There were no differences in the combined outcome between the two groups: 90.2% of the neonates in the NIRS-group and 89.9% in the control-group survived with normal outcome (relative risk [95% CI]; 0.96 [0.31–2.62]).Conclusions: In the present cohort of preterm neonates, monitoring of crSO2 and dedicated interventions in addition to routine care during transition period after birth did not show an impact on mortality and fidgety movements defined as normal or pathological at six to 20 weeks corrected age. What is Known• Fidgety movements display early spontaneous motoric pattern and may provide early information about a potential development of cerebral palsy in preterm neonates. What is New • This retrospective observational study of the randomised-controlled multicentre COSGOD III trial is the first study investigating the potential influence of cerebral oxygenation guided resuscitation during postnatal transition period on combined outcome of mortality and fidgety movements up to 20 weeks of corrected age in very preterm neonates.• This study adds to the growing interest of assessing cerebral oxygenation, that monitoring of cerebral oxygen saturation and dedicated interventions during postnatal transition period according to the COSGOD III trial has no significant influence on mortality and fidgety movements defined as normal or pathological in very preterm neonates.

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Influence of infections on the quality of general movements in premature infants

Cited by 7 publications

References 24 publications

RETRACTED ARTICLE: The levels of pro- and anti-inflammatory cytokines in premature infants with perinatal infections

RETRACTED ARTICLE: The levels of pro- and anti-inflammatory cytokines in premature infants with perinatal infections

The Relationship between General Movements and Risk Factors in Moderate-Late Preterm Infants: A Prospective Cohort Study

Cerebral oxygenation during immediate fetal-to-neonatal transition and fidgety movements between six to 20 weeks of corrected age: An ancillary study to the COSGOD III trial

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