Influence of inflammatory bowel disease on different dimensions of quality of life

Casellas, Francesc; López-Vivancos, Josefa; Badı́a, Xavier; Vilaseca, J; Malagelada, J.-R.

doi:10.1097/00042737-200105000-00017

Cited by 144 publications

(91 citation statements)

References 22 publications

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“…One of the major determinants of the extent to which quality of life is lowered by the diagnosis of IBD is disease activity (i.e., acute exacerbation vs. remission) [5, 56]. We were able to note an improvement in quality of life in individuals with relatively low disease activity, while there were no differences in clinical disease activity, assessed with the CAI, between the study groups at any time point.…”

Section: Discussionmentioning

confidence: 83%

“…On the other hand, it is also conceivable that the effectiveness of mind/body therapy may be inversely related to disease activity. Casellas et al [56] showed that systemic symptoms (i.e., nonspecific symptoms such as fatigue, general discomfort, energy and appetite problems) and emotional dysfunction persist during periods of remission. The present results support these findings, and suggest that at least some of these symptoms may effectively be improved by mind-body therapy.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Elsenbruch¹,

Langhorst²,

Popkirowa

et al. 2005

Psychother Psychosom

156

114

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Background: The aim of this study was to investigate the effects of mind-body therapy on neuroendocrine and cellular immune measures, health-related quality of life and disease activity in patients with ulcerative colitis (UC) in remission. Methods: Thirty UC patients in remission or with low disease activity were randomly assigned to an intervention group (n = 15) or a usual-care waiting control group (n = 15). Intervention consisted of a structured 60-hour training program over 10 weeks which included stress management training, moderate exercise, Mediterranean diet, behavioral techniques and self-care strategies. Quality of life, perceived stress and disease activity were assessed with standardized questionnaires (IBDQ, SF-36, PSS, CAI). In addition, the distribution of circulating lymphocytes and lymphocyte subsets as well as the β-adrenergic modulation of TNF-α production in vitro were analyzed. Urine catecholamines and plasma cortisol, prolactin and growth hormone were measured pre- and postinterventionally, and were compared with a healthy control group (n = 10). Results: In response to therapy, patients in the intervention group showed significantly greater improvement in the SF-36 scale Mental Health and the Psychological Health Sum score compared with changes observed in the usual-care waiting control group. Patients in the intervention group showed significantly greater improvement on the IBDQ scale Bowel Symptoms compared with the control group. However, no significant group differences in circulating lymphocyte subsets or endocrine parameters were observed in response to therapy. In addition, no significant effects of intervention on either the basal levels of TNF-α or the suppressive action of the β-adrenergic agonist isoproterenol on TNF-α production were observed. Conclusion: Mind-body therapy may improve quality of life in patients with UC in remission, while no effects of therapy on clinical or physiological parameters were found, which may at least in part be related to selective patient recruitment.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Elsenbruch¹,

Langhorst²,

Popkirowa

et al. 2005

Psychother Psychosom

156

114

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“…Inflammatory bowel disease (IBD), a chronic condition with fluctuating symptoms, an unpredictable course, and high rates of surgery, is thought to have similar negative repercussions [8][9][10][11][12][13][14][15] . Quality of life has been found to decline in parallel with increased disease severity 16 .…”

Section: Introductionmentioning

confidence: 99%

Stress Coping, Distress, and Health Perceptions in Inflammatory Bowel Disease and Community Controls

Graff

Walker

Clara

et al. 2009

American Journal of Gastroenterology

108

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Psychological health and IBD 2Background: This study compares a community IBD sample with a matched non-IBD community sample on psychological functioning and health perceptions. Methods:Participants in the population-based Manitoba IBD Cohort Study (n=388) were directly compared with sex, age, and region-matched controls from a national random-sample health survey on aspects of psychological health, coping, and perceived general health. Results:The IBD sample overall had lower psychological wellbeing and mastery, and higher distress than the non-IBD controls (p < 0.02). Those with IBD used avoidant coping significantly more often, and active coping modestly more often than the non-IBD sample; both had similar levels of 'self-soothing' behaviors. Crohn's disease and ulcerative colitis participants had similarly poor levels of functioning along these dimensions compared to the non-IBD sample, as did those with active disease (p < 0.01). However, those with inactive disease were similar to the non-IBD sample, and had modestly higher mastery levels. While nearly half of the non-IBD group reported chronic health conditions, those with IBD were threefold more likely to report poorer health (OR 3.07, 95% CI 2.10-4.47). Psychological factors explained a greater amount of variance in perceived health for the IBD than the non-IBD sample. Conclusions:Those with IBD have significantly poorer psychological health than those without IBD and view their general health status more negatively, although adaptive stress coping strategies were similar. However, when disease is quiescent there is little detriment to functioning. Active disease should be a flag to consider psychological needs in the care of the IBD patient.Psychological health and IBD 3

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“…Otros factores independientes reconocidos como el sexo femenino o el nivel educacional también existen (6). En cualquier caso, el factor más importante en la CVRS en la EII son los brotes de la enfermedad, afectando la CVRS del sujeto tanto en la percepción cualitativa como cuantitativa (7,8). No obstante, experiencias pasadas con la EII no influencian significativamente con la percepción de salud (9).…”

Section: Introductionunclassified

Traducción, adaptación y validación al español del cuestionario de calidad de vida de 32 ítems (IBDQ-32) de la enfermedad inflamatoria intestinal

Masachs

Casellas

Malagelada

2007

Rev. esp. enferm. dig.

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RESUMENIntroducción: la medida de la calidad de vida relacionada con la salud (CVRS) tiene una reconocida importancia en la evaluación, el manejo y el seguimiento de la enfermedad inflamatoria intestinal. El instrumento de medida más utilizado es la versión de 32 ítems del Inflammatory Bowel Disease Questionnaire (IBDQ-32), que no está adaptado al español.Objetivo: traducir la versión del IBDQ-32 al español y determinar su validez, fiabilidad y sensibilidad tanto en la colitis ulcerosa como en la enfermedad de Crohn.Método: estudio prospectivo en dos fases: traducción y posterior validación del IBDQ-32 al español. La traducción se ha basado en la versión al español validada del IBDQ-36, y los ítems del IBDQ-32 no incluidos en el IBDQ-36 se tradujeron "de novo". Una vez terminada la traducción del IBDQ32, se aplicó un cuestionario específico de comprensión. Para determinar las propiedades psicométricas del IBDQ-32, un grupo de pacientes completó el IBDQ-36 ya validado al español y el IBDQ-32.Resultados: se han incluido 84 pacientes (53 con enfermedad de Crohn y 31 con colitis ulcerosa). La mediana de la puntuación global de ambos cuestionarios en los 84 pacientes no fue diferente (6,1 vs. 6,2, p = ns) y su correlación de Spearman fue muy significativa (r = 0,97, p < 0,001). La capacidad de discriminar entre pacientes con brote y remisión también fue equivalente en ambos cuestionarios (6,4 vs. 6,4 con r = 0,96 en remisión y 3,8 vs. 3,9 con r = 0,95 en actividad, p < 0,001 remisión vs actividad). Estos resultados se reprodujeron en el análisis para EC y CU independientemente (6,4 vs. 6,4 y 6,7 vs. 6,6 respectivamente, p = ns).Conclusión: la versión en castellano de 32 ítems del IBDQ es válida y discriminativa para ser aplicada en pacientes con enfermedad de Crohn o colitis ulcerosa. ABSTRACTIntroduction: the measurement of health-related quality of life (HRQoL) has an established relevance in the assessment, management, and follow-up of inflammatory bowel disease. The most commonly used measuring instrument is the 32-item version of Inflammatory Bowel Disease Questionnaire (IBDQ-32), which has never been adapted to Spanish.Objective: to translate IBDQ-32 into Spanish, and to establish its validity, reliability, and sensitivity both in ulcerative colitis and Crohn's disease.Method: a prospective study in two phases -translation into Spanish and subsequent validation of IBDQ-32. Translation was based on the validated Spanish version of IBDQ-36, and IBDQ-32 items not included in IBDQ-36 were translated from scratch. Once the IBDQ32 translation was completed a comprehensionspecific questionnaire was administered. To establish IBDQ-32 psychometric properties a group of patients completed both the validated Spanish version of IBDQ-36 and IBDQ-32.Results: eighty-four patients (53 with Crohn's disease and 31 with ulcerative colitis) were included. Median overall scores in both questionnaires for all 84 patients did not differ (6.1 vs. 6.2, p = ns), and Spearman's correlation was highly significant (r = 0.97, p < 0.001). T...

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Influence of inflammatory bowel disease on different dimensions of quality of life

Abstract: Quality of life is impaired in IBD. During relapse, clinicians should pay attention to digestive symptoms and psychological distress. In remission, they should be sensitive to systemic symptoms.

Cited by 144 publications

References 22 publications

Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Stress Coping, Distress, and Health Perceptions in Inflammatory Bowel Disease and Community Controls

Traducción, adaptación y validación al español del cuestionario de calidad de vida de 32 ítems (IBDQ-32) de la enfermedad inflamatoria intestinal

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