Influence of inhaled bacteriophage therapy on oral mucosal immunity in children with acute tonsillitis

Turdieva, Shokhida T.; Ganieva, Durdona K.; Nasirova, Gulmira R.

doi:10.15789/2220-7619-ioi-2081

Russian Journal of Infection and Immunity

2023

DOI: 10.15789/2220-7619-ioi-2081

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Influence of inhaled bacteriophage therapy on oral mucosal immunity in children with acute tonsillitis

Shokhida T. Turdieva,

Durdona K. Ganieva,

Gulmira R. Nasirova

Abstract: The study aimed to assess the effect of inhaled bacteriophage therapy on oral mucosal immunity in children with acute tonsillitis. Materials and methods. We examined 212 patients aged 4 to 15 years old with acute tonsillitis and 110 age-matched apparently healthy children. Research methods: calculating the Neutrophil to lymphocyte ratio (NLR), saliva diagnostics - secretory immunoglobulin (sIgA) and the pro-inflammatory cytokine (TNF-). Taking into account the scheme of the treatment, the patients were d… Show more

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2024

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Cited by 2 publications

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Asymptomatic nasopharingeal carrying of Streptococcus pneumoniae in preschool children

Makhkamova,

Shamansurova,

Turdieva

2024

Medicinskij sovet

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Introduction. Despite the availability of modern, effective antibiotics and vaccines, up to 825 000 children under five years of age worldwide suffer from severe pneumococcal infection every year.Aim. To study the prevalence and manifestation of asymptomatic carriage of St. pneumoniae in unvaccinated preschool children.Materials and methods. The study design was a prospective cohort study that began before the inclusion of pneumococcal vaccination in the National Preventive Vaccination Calendar of Uzbekistan (2015). The microbiota of the nasopharynx was studied in 236 practically healthy children, of which children attending preschool, from 3 to 5 years old – 143 (60.6%), unorganized children from 1.5 to 3 years old – 93 (39.4%). According to standard methods, a bacteriological analysis (bacterial culture) was carried out to detect St. pneumoniae in a nasopharynx smear.Results and discussion. Asymptomatic nasopharyngeal carriage of St. pneumoniae was detected in 40.7% of those observed, which was higher than the detection rate of H. influenzae – 22.0% (52/236), as well as Moraxella catarrhalis – 13.6% (32/236), and in children attending kindergartens, the detection rate was two times higher (50.4% versus 25.8%), compared to unorganized children. According to two-year observations, a more aggressive effect of pathogens was noted in young children (unorganized children). Repeated episodes of pneumonia were noted in 29.2%, which is 5.2 times more than in children from the second age group (5.6%). The data obtained indicate a high incidence of children under three years of age with St. pneumoniae carriage.Conclusion. Among unvaccinated children under five years of age, asymptomatic nasopharyngeal carriage of St. pneumoniae was 40.7%, and the transition of asymptomatic carriage to invasive respiratory diseases reached 97.9%, which indicates the need for family doctors to organize and conduct effective vaccination of children before their admission to preschool institutions.

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Asymptomatic nasopharingeal carrying of Streptococcus pneumoniae in preschool children

Makhkamova,

Shamansurova,

Turdieva

2024

Medicinskij sovet

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Application of bacteriophage therapy in the treatment of children with acute tonsillitis

Tolkunovna,

Nishanovich,

Kizi

2024

International Journal of Pediatrics and Adolescent Medicine

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Context In pediatrics, there is an increasing interest in the therapeutic efficacy of inhaled bacteriophages for treating infectious diseases of the upper respiratory tract in children. Aim To analyze the effectiveness of inhaled bacteriophage therapy in children with acute tonsillitis (AT). Settings and Design Clinical observation of patients was based on a randomized, controlled research method. Methods and Material A total of 212 sick children aged 4–15 years who had AT were examined. Bacteriophage therapy was carried out by nebulizer inhalation using the liquid polyvalent piobacteriophage. Patients were divided into two groups based on the treatment method. One group of patients received a course of bacteriophage therapy against the background of standard treatment. Results When patients sought medical help, during the general clinical examination, the following were noted: cervical lymphadenopathy (98.6%), hyperemia of the tonsils and hyperplasia (98.1%), against the background of hyperthermia. Bacteriological analysis of the pharynx mucus showed that the main causative agents of AT in children were the bacteria Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae. Patients who underwent inhaled bacteriophage therapy in the early stages of treatment experienced a 1.4-fold greater disappearance of objective signs of pathological processes in the tonsils against the backdrop of rapid improvement in the well-being of sick children. Moreover, the use of a combination of antibiotic therapy and bacteriophage therapy led to a decrease in the detection of pathogenic bacteria, and the effectiveness of drug treatment increased four times. Conclusion The use of bacteriophage therapy in the complex treatment of AT in children contributes to a more rapid relief of the acute period against the background of an improvement in the subjective assessment of well-being by up to 25%, and a decrease in the detection of pathogenic bacteria.

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Influence of inhaled bacteriophage therapy on oral mucosal immunity in children with acute tonsillitis

Cited by 2 publications

References 34 publications

Asymptomatic nasopharingeal carrying of Streptococcus pneumoniae in preschool children

Asymptomatic nasopharingeal carrying of Streptococcus pneumoniae in preschool children

Application of bacteriophage therapy in the treatment of children with acute tonsillitis

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