Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats.

Leichter, Joseph; McNeill, John H.; Basu, Tapan K.; Dunn, Bruce P.

doi:10.3164/jcbn.11.47

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…This is in agreement with a previous study in which plasma retinol was restored to normal levels in diabetic rats treated with a single dose of insulin once a day for 3 weeks [19]. In that study, however, the insulin treatment failed to alter the diabetes associated increased hepatic vitamin A concentrations.…”

Section: Discussionsupporting

confidence: 82%

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Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats.

Tuitoek

Lakey

Rajotte

et al. 1995

J. Clin. Biochem. Nutr.

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Section: Discussionsupporting

confidence: 82%

“…Plasma [18] and liver [19] vitamin A were assayed by high-performance liquid chromatography (HPLC) with retinyl acetate (Sigma Chemical Co., St. Louis, MO) used as the internal standard. For extraction of with an isocratic solvent system of methanol : water (95: 5) at a flow rate of 1.5 ml/ min.…”

Section: Methodsmentioning

confidence: 99%

Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats.

Tuitoek

Lakey

Rajotte

et al. 1995

J. Clin. Biochem. Nutr.

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“…We employed chromatographic separation using HPLC in a system that has routinely been used by one of the authors for the detection and measurement of retinol in serum samples and biological tissues such as liver (Leichter et al, 1991).…”

Section: Methodsmentioning

confidence: 99%

Undetectability of vitamin A in bee brood

1995

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“…Dr. Basu's recent research investigation on diabetes is another major break through in the contemporary nutritional research realm. He was been the first researcher to report that type 1 diabetes (T1D) is associated with impaired meta-bolic availability of vitamin A due to its decreased hepatic hydrolysis as well as the synthesis of its carrier protein and that this secondary deficiency of the vitamin is linked to diabetes-related retinopathy [48,[51][52][53][54][55][56][57][58][59]. The subnormal vitamin A status in poorly controlled diabetic subject does not seem to respond to vitamin A supplementation but rather it increases its load in the liver leading to hepatoxicity [60].…”

Section: Dr T K Basu's Research Profile and Our Common Research Inmentioning

confidence: 99%

Genotype X Environment Interactions and Its Impact on Use of Medicinal Plants

Acharya¹,

Basu²,

Banik³

et al. 2010

TONUTRAJ

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There is a paradigm shift from cure to prevention when it comes to human health. We want to live a healthy life and prevent sickness using substances other than pharmaceuticals. The plant-based nutraceutical products or Natural Health Products (NHPs) as they are some times referred to are the most important groups that have the potential to fit the bill. However, these products are sold without proper science based information in spite of the fact that most researchers acknowledge the need for such information. Evidence-based scientific studies to support health and nutraceutical claims related to the use of medicinal plants and their extracts have to be undertaken. It is only through critical research efforts that we can provide strong endorsements for medicinal plant use and ensure consumer confidence in the industry. Much of the research published on the medicinal value of plants does not take into account variability generated from genetic differences among plants and their interaction with the environment. Research should be directed towards properly identifying plants with known medicinal properties which have been grown in environments that are conducive to consistent production of the active agents attributed to the plants. Production of dependable medicinal plant products can only be attained if we pay close attention to these research-based principles. This article was written with main goals: 1) To discuss the above points in greater detail with examples; and 2) to highlight life time accomplishments and significant contributions of a well respected nutritionist Dr. T. K. Basu and his collaboration in development of fenugreek as a NHP. We believe that collaboration among clinical and agricultural researchers is essential to make the NHPs utilized to its potential and the plants (parts such as seed, foliage or roots) should be developed to the extent that they can be used directly to take advantage of the synergistic effect of the chemical constituents.

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Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats.

Cited by 9 publications

References 7 publications

Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats.

Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats.

Undetectability of vitamin A in bee brood

Genotype X Environment Interactions and Its Impact on Use of Medicinal Plants

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