Influence of integral and decaffeinated coffee brews on metabolic parameters of rats fed with hiperlipidemic diets

Gomes, Júlia Ariana de Souza; Faria, Bruno Generoso; Silva, Viviam de Oliveira; Zangerônimo, Márcio Gilberto; Miranda, José Romilson Paes de; Lima, Adriene Ribeiro; Pereira, Rosemary Gualberto Fonseca Alvarenga

doi:10.1590/s1516-89132013000500015

Cited by 7 publications

(6 citation statements)

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“…However, it may be due to the variations in the mode of coffee administration. Lipid lowering effects of coffee found in the present study could be related to caffeine, (methylxanthine) which stimulates lipolysis by increasing cellular levels of cAMP through antagonism adenosine receptors (A1) and inhibition of phosphodiesterase activity [25,27].…”

Section: Discussionmentioning

confidence: 62%

“…Evaluation of fasting serum lipid profiles showed that treating rats with 284 mg/kg BW/day of coffee had significantly lowered fasting serum levels of TG and LDL-C when compared to fructose control group (p = 0.031; 0.046) respectively. Consistent with these findings, Gomes et al reported that feeding of 7.2 mL/kg of body weight for 41 days significantly lowered lipid percentage in hyperlipidemic diet feeding rats [25]. In addition, Li et al reported CGA significantly lowered the levels of fasting serum TG, FFA, TC, and LDL-C in golden hamsters [18].…”

Section: Discussionmentioning

confidence: 73%

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Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

et al. 2019

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Coffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high fructose diet. A post-test experimental study was conducted on a total of 30 (9-10 weeks old) male albino Wistar rats. The rats were divided into 6 groups: group I (normal control)-fed on standard chow and plain tap water only; group II (fructose control)-fed on standard chow and 20% of fructose solution; group III-VI (treatment groups)-fed on standard chow, 20% of fructose solution and treated with 71, 142, 213 and 284 mg/kg body weight/day of coffee respectively for six weeks. At the end, body weight, serum glucose, uric acid and lipid profile levels were investigated. Data was entered and cleared by epi-data software version 3.1 and analyzed by one way ANOVA followed by Tukey post hoc multiple comparison tests using SPSS V. 23.00. Statistical significance was considered at p < 0.05. The results showed that body weight, fasting serum glucose and uric acid levels significantly lowered in rats treated with 213 (p = 0.047; 0.049; 0.026) and 284 (p = 0.035; 0.029; 0.010) mg/kg body weight/day of coffee compared to fructose control group. Fasting serum triglycide (TG) and low density lipoprotein (LDL-C) levels showed significant reduction in rats treated with 284 mg/kg body weight/day of coffee as compared to fructose control group (p = 0.031; 0.046) respectively. In conclusion, treating rats with coffee decreased body weight, fasting serum glucose, uric acid, TC, TG and LDL-C, and increased HDL-C in a dose dependent manner in rats feeding on high fructose diet, suggesting that coffee consumption may be helpful in ameliorating metabolic syndrome.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 73%

Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

et al. 2019

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“…It was like pectin polysaccharide. 11 Pectin is one of some species which water-soluble food and easy to fermented by intestine microflora. Because the compound of pectin inside is a good fiber source.…”

Section: Resultsmentioning

confidence: 99%

The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)

et al. 2020

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Green grass jelly (Premna oblongifolia merr) is a plant containing fiber and chlorophyll which can lower cholesterol and triglyceride levels. This study have aims to investigate the potency of green grass jelly extract (Premna oblongifolia Merr) to prevent hyperlipidemia. The animal mode used for this study is male Rattus norvegicus, Wistar strain, the age of 8 weeks, and weight of 200 g which is divided into 5 groups of treatment namely group Kn (negative control), Kp (positive control), Kp1, Kp2, and Kp3 induced with HFD and green grass jelly extract at a dose of 5.27 g/ kg BW/ daily, 8.43 g/ kg BW/ daily, 9.37 g/ kg BW/ daily. The data of infiltrating fatty cells and macrophage on aorta histopathology was analyzed by description. This research showed that the treatment of green grass jelly extract (Premna oblongifolia Merr) to animals of hyperlipidemia model reduced infiltration fatty cells and macrophage. The conclusion of this study was the green grass jelly extract was able to prevent an increase of fatty cells and macrophage infiltration of rat (Rattus noervegicus) induced with HFD on dose 9.37 g/ kg/ BW/ daily.

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“…About 120 adipocytes per region evaluated for each animal were randomly analyzed by ImageJ software. The following parameters were evaluated: (i) diameter, measured from the greatest distance between the edges of the cells; (ii) area, calculated from its delimitation; and (iii) density, using the square of the known area superimposed on certain fields of the captured images 22 …”

Section: Methodsmentioning

confidence: 99%

Effects of Moro orange juice (Citrus sinensis(l.) Osbeck) on some metabolic and morphological parameters in obese and diabetic rats

et al. 2020

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BACKGROUNDNutritional intervention with the use of phytochemicals is an important method for the treatment and prevention of a metabolic syndrome. The objective of this study was to chemically characterize Moro orange juice. The influence of juice intake on metabolic parameters of rats that were obese, diabetic or both by means of body mass management after the activation of anthocyanins during refrigerated storage was also assessed.RESULTSJuice intake reversed most of the metabolic abnormalities exhibited by obese rats, including reduction of body mass and improvement of the biochemical profile. The loss of body mass by diabetic animals and obese and diabetic animals was not attributed to juice intake, but to type I diabetes mellitus. In these animals, no improvement was observed in the biochemical profile, liver enzymes and glycemia, so this treatment model was deemed unfeasible.CONCLUSIONThe beneficial effects cannot be explained only by the anthocyanin C3G present in the juice, but rather, by the synergism between all the components. Studies in humans are needed to determine whether the ingestion of this orange can be recommended as an effective strategy to prevent or ameliorate complications of obesity. © 2020 Society of Chemical Industry

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Influence of integral and decaffeinated coffee brews on metabolic parameters of rats fed with hiperlipidemic diets

Abstract: The objective of this study was to evaluate the influence of integral and decaffeinated coffee brews (Coffea arabica L and C. canephora

Cited by 7 publications

References 32 publications

Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)

Effects of Moro orange juice (Citrus sinensis(l.) Osbeck) on some metabolic and morphological parameters in obese and diabetic rats

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