Cross-laminated timber (CLT) floors are typically an assembly of prefabricated panels connected together on the site. CLT offers a wide range of configuration possibilities, as it can be easily pre-cut into various shapes and sizes, making it suitable for use in different architectural design requirements. However, available CLT design guidelines do not apply to complex-shaped CLT floors, i.e. unconventional geometry of floor plans including concave polygons, arches and openings. This paper presents a numerical vibration analysis of such a floor with openings, which represents a standard floor structure for residential and commercial buildings. Influence of panel orientation and inter-panel connections on modal properties and vibration response induced by a single pedestrian walking is analysed and discussed.