Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis

Abstract

ABSTRACT. We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1b and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796). The genotype distributions of IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796) were in HardyWeinberg equilibrium for the control group. Multivariate regression analyses showed that subjects carrying the rs1143634 TT genotype had a significantly increased risk of acute pancreatitis, with an adjusted odds ratio (95% confidence interval) of 2.11 (1.03-4.51). Subjects carrying the IL-1β rs1143634 TT genotype had a significantly increased risk of acute pancreatitis in our Chinese population.

Association of interleukin gene polymorphisms with the risk of coronary artery disease

“…Genetic variants impacting cytokine function might also alter the expression of cytokine genes, and thus influence the pathology of vascular lesions (Weng et al, 2010;Khankhanian et al, 2013). Previous studies have indicated that genetic variants of interleukin genes such as interleukin-1β (IL-1β), , and IL-23A could affect the development of CAD (Romani et al, 2014;Armingohar et al, 2015;Chi et al, 2015;Jia et al, 2015;Tripathi et al, 2015;Yue et al, 2015), but the results have been inconsistent. In our study, we reported that the IL-6 -174G/C and IL-10 -1082A/G polymorphisms are correlated with an elevated risk of CAD in a multivariate analysis.…”

“…Polymorphisms in cytokine genes could alter the function of protein expression and thus influence their roles in the process of cardiovascular disease. Specifically, previous studies have indicated that genetic variants of interleukin genes, such as interleukin-1β (IL-1β), , and IL-23A could affect the development of CAD (Romani et al, 2014;Armingohar et al, 2015;Chi et al, 2015;Jia et al, 2015;Tripathi et al, 2015;Yue et al, 2015).…”

Investigation of the association between Interleukin-10 polymorphisms and risk of acute pancreatitis in a Chinese population

“…Several previous studies have reported the association between interleukin gene polymorphisms and acute pancreatitis (Schneider et al, 2004;Chen and Nie, 2008;Bao et al, 2015;Chi et al, 2015). Schneider et al (2004) investigated the role of TNF-α, TGF-β1, IL-10, and IFN-γ gene polymorphisms in the development of alcoholic chronic pancreatitis, but they did not find that genetic variants played a dominant role in alcoholic chronic pancreatitis.…”

“…However, not all subjects with similar risk factors develop acute pancreatitis, which suggests that genetic variations could influence the development of the condition. Several studies have reported that genetic polymorphisms play an important role in the development of acute pancreatitis such as interleukin-8 (IL-8), IL-1β, IL-6, toll-like receptor, and tumor necrosis factoralpha (TNF-α) genes (Yin et al, 2012;Yin et al, 2013;Bao et al, 2015;Chi et al, 2015;MatasCobos et al, 2015).…”

Influence of interleukin-18 gene polymorphisms on acute pancreatitis susceptibility in a Chinese population

“…Not all individuals subject to acute pancreatitis risk factors go on to develop this disease, which indicates that genetic influences may contribute to the development of this disease. Recently, many studies have suggested that interleukin (IL) genes, such as IL-10, play an important role in the development of acute pancreatitis (Bao et al, 2015b;Chi et al, 2015;Jia et al, 2015;Li et al, 2015a).…”