Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children

Ibrahim, Ola M.; Gabre, A; Sallam, Sara F.; El-Alameey, Inas R.; Sabry, Rania N.; Galal, Essam M.; Tawfik, Sawsan M.; Zarouk, Waheba A.; Mosaad, Rehab M.; Ramadan, Abeer

doi:10.3889/oamjms.2017.175

Cited by 17 publications

(14 citation statements)

References 14 publications

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“…On correlating the IL-6 levels to the genotypes, no significant difference in IL-6 concentration among different genotypes in both study groups. These results are similar to a study performed on Egyptian obese children which reported also that the IL-6 concentration was independent of -174 G/C in all study subjects [26]. Other studies also support this finding [27,28].…”

Section: Serum Levels Of Serum Il-6supporting

confidence: 91%

Is there a correlation between -174(G/C) polymorphism of IL-6 gene and the incidence of acute myocardial infarction?

Nosseir

Shaban

Rahman³

2021

Journal of Genetic Engineering and Biotechnology

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Background Cardiovascular disease (CVD) remains the major cause of death worldwide. Most CVD can be prevented by addressing risk factors. Acute myocardial infarction (AMI) is an inflammatory disorder characterized by changes in several cytokines including the interleukins (ILs). Studies are running to evaluate the genetic variation in the inflammatory system and their influence on the risk factors for CVD aiming for future prevention of this global disease. The aim of the current study was too investigate the association of -174 (G/C) IL-6 polymorphism with the incidence of AMI in a representative sector of the Egyptian population and to examine the contribution of IL-6, as a biomarker, in the pathogenesis of AMI. Genotyping of -174 (G/C) IL-6 polymorphism was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) while IL-6 levels were assayed by ELISA. Results The genotype distribution of -174 (G/C) IL-6 gene was not significantly different between the control subjects (GG 81.7%, GC 16.3%, CC 1.9%) and the AMI patients (GG 79%, GC 19%, CC 2%).The serum levels of IL-6 were significantly elevated in the AMI patients in comparison to the control subjects (P < 0.0001). Conclusions There is no significant association of -174(G/C) polymorphism in the promoter sequence of IL-6 and the incidence of AMI in the examined sample of Egyptian population. Elevated levels of serum IL-6 confirmed the relationship between inflammation and the incidence of AMI.

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Section: Serum Levels Of Serum Il-6supporting

confidence: 91%

Is there a correlation between -174(G/C) polymorphism of IL-6 gene and the incidence of acute myocardial infarction?

Nosseir

Shaban

Rahman³

2021

Journal of Genetic Engineering and Biotechnology

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“…Both positive and negative associations between obesity and IL-6 polymorphisms in multiple loci have been reported [3,[18][19][20][21][22]. Our study, reporting the lack of a relationship between obesity parameters (BMI and fat%) and IL-6 polymorphisms rs1800795, rs1800796 and rs13306435 in a homogenous population poses an additional voice in this discussion.…”

Section: Discussionmentioning

confidence: 48%

IL-6 Polymorphisms Are Not Related to Obesity Parameters in Physically Active Young Men

Maculewicz

Antkowiak

et al. 2021

Genes

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Interleukin 6 (IL-6) is a cytokine with both pro- and anti-inflammatory actions, but is also considered as a “metabolic hormone” involved in immune responses, affecting glucose, protein and lipid metabolism. It has been proposed to be related to obesity, but various results have been presented. Thus, in this study, the very homogenous population of young, male military professionals, living in the same conditions involving high physical activity, has been selected to avoid the influence of environmental factors. The subjects were divided into groups depending on the obesity parameters BMI (body mass index) and fat percentage (fat%), and the following IL-6 SNPs (Single Nucleotide Polymorphisms) were analyzed: rs1800795, rs1800796 and rs13306435. No relation was found between obesity parameters and IL-6 polymorphisms rs1800795, rs1800796 and rs13306435. It may be postulated that even if a genetic predisposition involves IL-6 genes, this effect in individuals with obesity of a low grade is minor, or can be avoided or at least markedly reduced by changes in lifestyle.

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“…A recent study with post‐menopausal female with osteoporosis illustrated that the reduction of estradiol concentration causes a rise in the activity of IL‐1β, IL‐6 and TNF‐α, 34 and it could happen with patients in the studies. Some polymorphisms are associated with the IL‐6 gene, one of them is −174 G/C rs1800795 that is located in promoter region 35 . This polymorphism affects the constitutive transcription of the interleukin gene by controlling the production 36 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of IL‐6 levels and +3954 polymorphism of IL‐1β in burning mouth syndrome: A systematic review and meta‐analysis

Campello

Pellizzer

Vasconcelos

et al. 2020

J Oral Pathology Medicine

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This study evaluated IL‐6 salivary levels as well as the +3954 polymorphism of IL‐1β in patients with burning mouth syndrome and healthy individuals, through case‐control studies. This systematic review and meta‐analysis followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. We conducted this research in PubMed/MEDLINE, Cochrane Library and Web of Science databases. The risk of bias was measured based in the Newcastle‐Ottawa Scale. Researches with a group of patients with burning mouth syndrome and a control group in which the presence of the +3954 polymorphism of IL‐1β and/ or IL‐6 salivary levels through non‐stimulated saliva were evaluated to detect if this interleukin concentrations are increased in patients and if the polymorphism is a risk factor for this syndrome. We identified seven studies with total of 440 participants, 229 patients with burning mouth syndrome and 211 healthy controls, ages 24‐84 years old. The female gender was predominant. Patients in the majority of studies did not present increased levels of IL‐6 and the +3954 polymorphism of IL‐1β is not a risk factor for this syndrome. A few studies researched biomarkers in this pathology and more investigations are required not only to identify salivary levels and the polymorphism evaluated, but also other interleukins and polymorphisms in order to clarify the etiopathogenesis of this syndrome as well as for propose new diagnostic methods and treatments.

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Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children

Cited by 17 publications

References 14 publications

Is there a correlation between -174(G/C) polymorphism of IL-6 gene and the incidence of acute myocardial infarction?

Is there a correlation between -174(G/C) polymorphism of IL-6 gene and the incidence of acute myocardial infarction?

IL-6 Polymorphisms Are Not Related to Obesity Parameters in Physically Active Young Men

Evaluation of IL‐6 levels and +3954 polymorphism of IL‐1β in burning mouth syndrome: A systematic review and meta‐analysis

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