Influence of interleukin-6 G-174C gene polymorphism on coronary artery disease, cardiovascular complications and mortality in dialysis patients

Aker, Sendogan; Bantis, Christos; Reis, Philip; Kuhr, Nicola; Schwandt, Christina; Grabensee, B; Heering, Peter; Ivens, Katrin

doi:10.1093/ndt/gfp141

Cited by 40 publications

(33 citation statements)

References 31 publications

(36 reference statements)

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“…Studies were excluded if they used study designs other than case-control or cross-sectional methods (e.g., prospective cohort of patients without healthy control subjects) [25][26][27][28][29][30], did not present relevant data to calculate the OR and its variance, or examined cardiovascular events associated with other systemic diseases [31]. For overlapping studies, only the study with the largest sample numbers was included, such as coronary artery disease (CAD) in Poland [22,32], MI [33,34] and history of IS in Italy [35,36], and IS/transient ischemic attacks in Austria [37,38].…”

Section: Publication Searchmentioning

confidence: 99%

Lack of an association between interleukin-6 gene promoter polymorphisms (−174G/C, −572G/C) and ischemic heart disease and/or ischemic stroke: A meta-analysis

Ma¹,

Tang²,

Xu³

et al. 2011

Human Immunology

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Section: Publication Searchmentioning

confidence: 99%

Lack of an association between interleukin-6 gene promoter polymorphisms (−174G/C, −572G/C) and ischemic heart disease and/or ischemic stroke: A meta-analysis

Ma¹,

Tang²,

Xu³

et al. 2011

Human Immunology

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“…Thus, in the study of S. Aker et al the CC genotype was significantly associated with the violation of patients survival, being an independent risk factor for death (HR 3.58, 95 % CI 1.41-9.07, p < 0.01) according to the results of the multivariate analysis [12]. In another study conducted by M. P. Sie et al, the association of 174-G/C promoter polymorphism with the level of Interleukin-6 and C-reactive protein and arterial stiffness was studied.…”

Section: Review Of Literaturementioning

confidence: 91%

The role of cytokine gene polymorphism in the development of acute myocardial infarction

Sid

2017

ZMJ

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The continuous growth of cardiovascular diseases is one of the important challenges facing the modern medicine. They are the primary cause of death both in developed countries and in Ukraine in particular.The aim of the study is to perform analysis of modern literary sources related to the role of cytokine gene polymorphism in the development of acute myocardial infarction.The basis for the search for candidate genes was study of individual characteristics and identifying genetic polymorphisms that increase the risk of triggering mechanisms of atherosclerotic lesions of the coronary vessels and the consequent acute myocardial infarction development. Cytokine genes feature a very high level of polymorphisms. The obtained results of the study are quite contradictory, in addition there is no consensus on their application. One of these candidate genes is the gene encoding interleukin-6 production. This is one of the proinflammatory cytokines, elevated levels of which are associated with the development and course of coronary heart disease, as well as with the processes of the atherosclerotic plaque destabilization. Polymorphic marker in interleukin-6 (-174-G/C) gene promoter is associated with IL-6 gene expression level and the level of Interleukin-6 in plasma, and can affect the course of ischemic heart disease. The tumor necrosis factor-α is a multifunctional proinflammatory cytokine which is produced mainly by monocytes and macrophages. Concentration of tumor necrosis factor-α in blood plasma is constantly increased in patients after acute myocardial infarction with an increased risk of recurrent coronary events. These data support the hypothesis that stable patients are at risk of constant inflammatory instability. Increased production of tumor necrosis factor-α is considered an important cause of destabilization of atherosclerotic plaques. The gene cluster of tumor necrosis factor-α is within the region of class III genes of highly polymorphic major histocompatibility complex, located on human chromosome 6 at the position 6p21.1-21.3. Another candidate gene encodes interleukin-10, being an anti-inflammatory cytokine is an inhibitor of inflammation located on chromosome 1 at the position 1q31-q32. The research identified a number of IL-10 gene polymorphisms at positions -592, -627, -1082.Conclusions. Analysis of the above literature allows us to make a conclusion that: first, the concentration of cytokines depends on the genetic characteristics of an individual; secondly, cytokine gene polymorphism may be of importance in regard to the course of coronary heart disease.Значення поліморфізму генів цитокінів у розвитку гострого інфаркту міокарда Є. В. СідьОдна з важливих проблем сучасної медицини -безперервне зростання серцево-судинних захворювань, що є провідною причиною смерті як у розвинених країнах світу, так і в Україні зокрема.Мета роботи -проаналізувати сучасні наукові літературні джерела щодо значення поліморфізму генів цитокінів у розвитку гострого інфаркту міокарда.Вивчення індивідуальних особливостей лю...

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“…There was no significant difference between patients with coronary revascularization (percutaneous transluminal coronary angioplasty with or without stent implantation and (or) CABG) and those without the need of revascularization. In addition, smokers with the CC genotype were an increased mortality risk compared to GG/GC carriers (41).…”

Section: Il-6 Gene Polymorphismmentioning

confidence: 96%

Interleukin-6 in cardiac surgery

Yuan

Lin

2017

Per Biol

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Influence of interleukin-6 G-174C gene polymorphism on coronary artery disease, cardiovascular complications and mortality in dialysis patients

Abstract: Our results suggest that IL-6 gene G-174C polymorphism is associated with the incidence of cardiovascular events and mortality in chronic dialysis patients.

Cited by 40 publications

References 31 publications

Lack of an association between interleukin-6 gene promoter polymorphisms (−174G/C, −572G/C) and ischemic heart disease and/or ischemic stroke: A meta-analysis

Lack of an association between interleukin-6 gene promoter polymorphisms (−174G/C, −572G/C) and ischemic heart disease and/or ischemic stroke: A meta-analysis

The role of cytokine gene polymorphism in the development of acute myocardial infarction

Interleukin-6 in cardiac surgery

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