Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas

Park, Kyung Jae; Kang, Sung Ho; Chae, Yang Seok; Yu, Mi Ok; Cho, Tai Hyoung; Suh, Jung Keun; Lee, Hoon Kap; Chung, Yong Gu

doi:10.3171/2009.4.jns09158

Cited by 33 publications

(24 citation statements)

References 61 publications

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“…The blots were probed with anti-AEG-1 (Invitrogen), anti-p-Akt, anti-Akt, and anti-Bcl-2 (Cell signaling Technology, Irvine, CA, USA) and with anti-beta actin (BioVision Research Products, Mountain View, CA, USA) antibodies. Immunohistochemistry for AEG-1 was performed in the meningioma specimens, and the degree of expression was graded using a threetiered system according to the percentage of positive cells and staining intensity: no or weak expression, moderate expression, and strong expression [23,24]. Cell proliferation and colony formation assay IOMM-LEE and SF3061 meningioma cell lines transfected with AEG-1 siRNA or non-targeting siRNA were stained with trypan blue (Invitrogen) and counted using a hemocytometer at day 1, 2, and 3 after the transfection.…”

Section: Protein Analysismentioning

confidence: 99%

Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival

Park

Song

et al. 2014

J Neurooncol

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Astrocyte elevated gene-1 (AEG-1) has recently been proposed to be involved in tumor development, invasion, and metastasis in several human cancers. However, the functional importance of AEG-1 expression in human meningioma has not been determined. We investigate the level of AEG-1 expression by quantitative reverse transcription PCR, immunohistochemistry analysis, and western blotting in various human meningioma tissues and cells. To determine the suppressive effect of AEG-1 on meningioma progression, we inhibited AEG-1 expression using small interfering RNA and examined cell proliferation, apoptosis, colony formation and tumorigenicity in a mouse xenograft model. AEG-1 expression was frequently elevated at both mRNA and protein levels in meningioma tumor tissues and in meningioma-derived cells as well. This elevation was more commonly observed in high-grade tumors than in benign ones. The knockdown of AEG-1 led to a decrease in overall cell proliferation, as well as anchorage-independent growth of malignant meningioma. In addition, apoptotic cell death occurred in AEG-1 depleted meningioma cells through p-Akt and Bcl-2 suppression. Furthermore, a mouse xenograft meningioma model showed that inhibition of AEG-1 expression significantly decreased tumor growth. Altogether, these data show that the elevation of AEG-1 contributes to the malignant progression of meningiomas, suggesting that AEG-1 could be a novel therapeutic target against human meningiomas.

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Section: Protein Analysismentioning

confidence: 99%

Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival

Park

Song

et al. 2014

J Neurooncol

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“…11,18,19,21 The physiological basis for meningioma-associated cerebral edema is attributed to blood-brain barrier breakdown. Biological factors such as expression of VEGF, matrix metalloproteinase-9, 16 and interleukin-6 17 trend toward an increase in PTBE. These molecules play an important role in the alteration of vessel permeability and the release of local mediators causing extracellular vasogenic edema.…”

Section: Discussionmentioning

confidence: 95%

“…1,15,20 While there are technical and surgical factors that portend poor results, one important contributing factor toward mortality and post- operative complications is the presence of preoperative PTBE. 3,4,15 Other factors associated with PTBE include histological subtype, increased tumor size, irregular margins, pial cortical blood supply, location at the midline 10 or frontal skull base, 17 and poor basal venous drainage. 11,18,19,21 The physiological basis for meningioma-associated cerebral edema is attributed to blood-brain barrier breakdown.…”

Section: Discussionmentioning

confidence: 99%

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The lion's mane sign: surgical results using the bilateral fronto-orbito-nasal approach in large and giant anterior skull base meningiomas

Li¹,

Portman²,

Rahal

et al. 2014

JNS

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Object. Concerns about extreme peritumoral edema and its ensuing surgical and perioperative complications led the authors to use the bilateral fronto-orbito-nasal approach to remove midline anterior skull base meningiomas that were larger than 4 cm. The authors hypothesize that extreme vasogenic edema exemplified by finger-like hyperintensities extending into the bifrontal white matter and external capsule and/or the extreme capsule, coined the lion's mane sign (LMS), would help identify patients with a challenging postoperative course. They hypothesize that the LMS would better predict symptomatic postoperative cerebral edema than the edema index (EI).Methods. This is an observational case series of 9 patients. The authors noted the grade, pathology, tumor volume, EI, and the presence or absence of the LMS in all tumors. They used the intensive unit care (ICU) length of stay as a nonspecific measure reflecting postoperative symptomatic cerebral edema. Comparisons of edema-related postoperative complications and the EI were made between patients with and without an LMS.Results. Bifrontal hyperintensities, extending into at least three-eighths of the length of the external capsules on T2-weighted MRI, seen in 4 of 9 patients, portended a longer postoperative ICU stay. The presence of an LMS better predicted postoperative complications related to cerebral edema than tumor grade, pathology, volume, or EI.Conclusions. The LMS predicts an increased duration of stay in the ICU after a bilateral fronto-orbito-nasal approach for resection of large and giant anterior skull base meningiomas. Furthermore, the LMS better predicted increased length of stay in the ICU than did the EI. (http://thejns.org/doi/abs/10.3171/2013.11.JNS13552) key WorDS • lion's mane sign • peritumoral brain edema • edema index • oncology 315Abbreviations used in this paper: EI = edema index; ICU = intensive care unit; LMS = lion's mane sign; LOS = length of stay; PONES = postoperative nonconvulsive encephalopathic status; PTBE = peritumoral brain edema.

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“…However, in the few case-reports on the serum level of IL-6 in meningioma patients, normal or increased levels of IL-6 in serum is reported (Rittierodt et al 2001;Arima et al, 2005;Sato et al, 2010). The local increased level of IL-6 is also shown to contribute to the development of brain edema in meningiomas (Park et al, 2010). The increased level of IL-6 in gliomas, however, has been restricted to GBM cases (Meir et al, 1990;Tofaris et al, 2002;Van Lee et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma

Doroudchi

Pishe²,

Malekzadeh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: There is a Th1/Th2 cytokine imbalance and expression of IL-17 in patients with brain tumours. We aimed to compare the levels of IL-17A and IL-6 in sera of glioma, meningioma and schwannoma patients as well as in healthy individuals. Materials and Methods: IL-17A and IL-6 levels were measured in sera of 38 glioma, 24 meningioma and 18 schwannoma patients for comparison with 26 healthy controls by commercial ELISA assays. Results: We observed an increase in the IL-17A in 30% of glioma patients while only 4% and 5.5% of meningioma and schwannoma patients and none of the healthy controls showed elevated IL-17A in their sera (0.29±0.54, 0.03±0.15 and 0.16±0.68 vs. 0.00±0.00pg/ml; p=0.01, p=0.01 and p=0.001, respectively). There was also a significant decrease in the level of IL-6 in glioma patients compared to healthy controls (2.34±4.35 vs. 4.67±4.32pg/ml; p=0.01). There was a direct correlation between the level of IL-17A and age in glioma patients (p=0.005). Glioma patients over 30 years of age had higher IL-17A and lower IL-6 in their sera compared to the young patients. In addition, a non-significant grade-specific inverse trend between IL-17A and IL-6 was observed in glioma patients, where high-grade gliomas had higher IL-17A and lower IL-6. Conclusions: Our data suggest a Th17 mediated inflammatory response in the pathogenesis of glioma. Moreover, tuning of IL-6 and IL-17A inflammatory cytokines occurs during progression of glioma. IL-17A may be a potential biomarker and/or immunotherapeutic target in glioma cases.

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Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas

Cited by 33 publications

References 61 publications

Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival

Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival

The lion's mane sign: surgical results using the bilateral fronto-orbito-nasal approach in large and giant anterior skull base meningiomas

Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma

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