Influence of Intestinal Parasitism on Lactose Absorption in Well-Nourished African Children

Gendrel, D.; Richard-Lenoble, D; Kombila, M.; Dupont, Christophe; Moreno, Jean-Luc; Gendrel, C; Nardou, M.; Chaussain, M

doi:10.4269/ajtmh.1992.46.137

Cited by 16 publications

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“…Similar results were found by Gendrel and others, who reported that asymptomatic giardiasis does not increase the frequency of lactose intolerance in well-nourished children. 4 Furthermore, Tolboom and others 27 found that lactose malabsorption does not correlate with the presence of giardiasis, but milk intolerance manifested as diarrhea is more common in children with giardiasis than in healthy subjects. Because of the location of the disaccharidases in the intestinal brush border, any condition that damages its morphology (such as severe diarrhea), will result in a detrimental effect on these enzymes, and thus disaccharides absorption.…”

Section: Discussionmentioning

confidence: 99%

“…However, few studies have reported the potential effects of moderate or asymptomatic giardiasis on nutrient absorption, and thus the effects on the nutritional status of the host. 4,[25][26][27] For instance, de Morais and others found that asymptomatic giardiasis did not affect the intestinal absorption of iron in children with iron deficiency. 25 We have previously found that mild G. intestinalis infection did not affect energy metabolism (energy intake, basal metabolic rate, and total energy expenditure) in children.…”

Section: Discussionmentioning

confidence: 99%

“…3 One of the main complications of giardiasis is disaccharide (most frequently lactose) malabsorption. 4,5 Because of its interference with nutrient absorption, severe giardiasis may cause malnutrition and growth retardation in children. 6 However, many patients infected with G. intestinalis do not present symptoms or damage to the small intestine.…”

Section: Introductionmentioning

confidence: 99%

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Effects of asymptomatic Giardia intestinalis infection on carbohydrate absorption in well-nourished Mexican children.

Moya-Camarena¹,

Sotelo²,

Valencia³

2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. The aim of this study was to evaluate carbohydrate absorption in well-nourished children with asymptomatic giardiasis. Two groups were selected based on results of stool examination of 211 children attending pre-school centers in Hermosillo, Sonora, Mexico: a control group of six non-infected children, and an infected group of seven children harboring Giardia intestinalis, without gastrointestinal symptoms of disease. Carbohydrate absorption was determined in the control group, before and after drug therapy in the infected group by the hydrogen breath test. Hydrogen production after lactose ingestion was higher in children with giardiasis compared with control group and after anti-parasite treatment; however, hydrogen production was not high enough to classify children as lactose malabsorbers by the cut-off criteria. Similar results were obtained for xylose absorption. None of the children had hydrogen increments high enough to be considered xylose malabsorbers. In conclusion, children asymptomatically infected with G. intestinalis showed significantly higher hydrogen production. However, the biological relevance is questionable since they did not exceed cut-off criteria to classify them as carbohydrate malabsorbers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of asymptomatic Giardia intestinalis infection on carbohydrate absorption in well-nourished Mexican children.

Moya-Camarena¹,

Sotelo²,

Valencia³

2002

The American Journal of Tropical Medicine and Hygiene

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“…Parasitosis of children with ascaris (Taren et al 1987) and giardia (Tolboom et af. 1987) was shown to increase lactose maldigestion; a more recent study in well nourished African children (Gendrel et al 1992) showed a marginal effect of ascaris and no effect of giardia on lactose digestion. Perhaps the overall nutritional status of children is a more important determinant of the capacity to digest lactose.…”

Section: Secondary Lactase Deficiencymentioning

confidence: 93%

Lactose digestion and maldigestion: implications for dietary habits in developing countries

Rosado¹

1997

Nutr. Res. Rev.

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Milk is an important source of high quality protein. energy, calcium, potassium, phosphorus and riboflavin. It also has good functional properties and a highly acceptable taste, making milk a good alternative for the nutrition of children and for food programmes in developing countries. However, in some instances it has been advocated that milk or milk based products might not be appropriate for nutritional support, given the high prevalence of lactose intolerance among populations in those countries. After reviewing studies in different regions of the world it is concluded that: I . Prevalence of lactose maldigestion in children and adults is significantly reduced, to less than half in most studies, when assessed with a dose of milk similar to that normally taken in the diet, as distinct from a large dose of lactose used in the lactose tolerance test. 2. Lactose intolerance as a result of consuming a glass of milk occurs only in a small proportion (about 30% in most studies) of lactose maldigesters. Even this small group can ingest smaller amounts of milk without adverse symptoms and there is good evidence that colonic metabolism in these people adapts to the presence of lactose to reduce or eliminate adverse symptoms. 3. Lactose maldigestion and intolerance in children in developing countries is more likely to exist in association with gastrointestinal damage associated with diarrhoea, malnutrition andor infection. 4. There is no evidence to support a reduction or elimination of milk intake for people in developing countries because of lactose maldigestion or intolerance.

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“…Son varios los artículos publicados que apoyan o refutan diferentes relaciones (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Esto se debe a que el peso, la talla y, en general, el estado nutricional de un individuo a lo largo de su vida depende de la compleja interacción de una serie de variables entre las cuales están su propia información genética, patologías que pueden afectar su desarrollo desde la vida intrauterina, el nivel socioeconómico y las conductas alimentarias de la familia y la sociedad a las que pertenece, así como las patologías que retrasan su crecimiento y desarrollo durante la infancia, la niñez y la pubertad, entre las cuales el parasitismo intestinal es tan sólo una (1,12).…”

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Desnutrición y su relación con parasitismo intestinal en niños de una población de la Amazonia colombiana.

Ordóñez¹,

Angulo²

2002

biomedica

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En el mundo y principalmente en los países en vía de desarrollo, los parásitos intestinales y la desnutrición causan gran morbilidad, especialmente entre la población infantil. El presente estudio se desarrolló en un poblado de la Amazonia colombiana con el fin de determinar la frecuencia de parásitos intestinales, de desnutrición y para establecer, si se encontraban, relaciones entre ellos. Fueron incluidos 237 niños de quienes se recolectaron cuatro muestras de materia fecal para análisis parasitológicos; se calcularon los índices antropométricos talla para la edad (HAZ), peso para la edad (WAZ) y peso para la talla (WHZ) con respecto de la población de referencia internacional recomendada por la Organización Mundial de la Salud y, adicionalmente, se aplicó una encuesta socioeconómica diseñada por el estado colombiano. Los resultados arrojaron que el 86,1% se encontraba parasitado y el 54,4% tenía dos o más parásitos. El 29,5% del grupo presentó baja talla para la edad; 10,1% bajo peso para la edad y 2,5% bajo peso para la talla. HAZ y WAZ presentaron relación inversa con la edad y el número de parásitos, en tanto que el puntaje en la encuesta socioeconómica tuvo una relación directa con el número de parásitos e inversa con el índice HAZ; todas estas relaciones fueron estadísticamente significativas (p<0,05). En conclusión, las frecuencias de desnutrición y parasitismo intestinal en esta población son superiores a las informadas para el resto del país. Al igual que en estudios previos, la edad, el parasitismo intestinal y el estado socioeconómico son variables que se relacionan significativamente con el estado nutricional.Palabras clave: desnutrición, baja talla para la edad, bajo peso para la talla, parasitismo intestinal, poliparasitismo intestinal, antropometría. Malnutrition and its association with intestinal parasitism among children from a village in the Colombian Amazon regionIntestinal parasites and malnutrition cause high morbidity among children in developing countries. A study to establish the associations between intestinal parasitism and undernourishment was undertaken in a village in the Colombian Amazon region. Two hundred thirty seven children each provided four stool samples for parasitic analysis. Anthropometric indices were calculated based on height and weight (HAZ), weight and age (WAZ) and height and weight (WHZ) using the international growth standards recommended by the World Health Organization. Of the 237 children, 86.1% were carrying parasites, 54% had 2 or more parasites, 30% were stunted, 10% were underweight, and 2.5% were wasting. HAZ and WAZ indices were inversely related to age and number of parasites. Socioeconomic status was positively correlated with the number of parasites and inversely related to the HAZ index (p<0.05). In conclusion, frequencies of undernourishment and intestinal parasites among the sample population were higher than the national average for Colombia. As previous studies have indicated, age, intestinal parasitism and socio-economic level are variables si...

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Influence of Intestinal Parasitism on Lactose Absorption in Well-Nourished African Children

Cited by 16 publications

References 0 publications

Effects of asymptomatic Giardia intestinalis infection on carbohydrate absorption in well-nourished Mexican children.

Effects of asymptomatic Giardia intestinalis infection on carbohydrate absorption in well-nourished Mexican children.

Lactose digestion and maldigestion: implications for dietary habits in developing countries

Desnutrición y su relación con parasitismo intestinal en niños de una población de la Amazonia colombiana.

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