Influence of Intravenous Fish Oil-Enriched Lipid Emulsion on the Inflammatory Response in Children Post Gastrointestinal Surgery

Hanindita, Meta Herdiana; Widjaja, Nur Aisiyah; Irawan, Roedi; Hidajat, Boerhan

doi:10.3923/pjn.2019.1036.1041

Cited by 4 publications

(7 citation statements)

References 26 publications

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“…TNF-α and IL-6 levels peak in 1-2 hours after surgery 25 . Our previous study showed a significant difference in mean IL-6 levels between subjects receiving MCT/LCT and subjects receiving MCT/LCT/OO/FO 17 . Lin and Lowry stated that the half-life of IL-1β in systemic circulation is less than 10 minutes, making it more difficult to detect during stressful periods than TNF-α.…”

Section: Discussionmentioning

confidence: 91%

“…ω-3 may also act as a regulator of the immune system and mitigator of inflammation since it acts as a precursor for lipid mediator 16 . Our previous study showed lower levels of proinflammatory cytokines IL-6 and TNF-α in subjects who received the mixture of MCT/LCT/OO/FO compared with subjects who received MCT/LCT IVLE 17 . To our knowledge, there been no study regarding the effects of MCT/LCT/OO/FO IVLE on IL-1β and IL-8 levels and fatty acid composition in infants who undergo gastrointestinal surgery, compared to those who receive standard IVLE.…”

Section: Introductionmentioning

confidence: 91%

“…The formula used datas from our previous published research (reference no. 17). No, the power calculation is only valid for interleukin-1b.…”

Section: Open Peer Reviewmentioning

confidence: 99%

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Comparison of two lipid emulsions on interleukin-1β, interleukin-8 and fatty acid composition in infants post gastrointestinal surgery: a randomized trial

et al. 2020

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Background: Nutritional support plays an essential role for recovery in infants who undergo gastrointestinal surgery. The current standard type of intravenous lipid emulsion (IVLE) used as parenteral nutrition is the mixture of medium-chain triglyceride (MCT) and long chain triglyceride (LCT) rich in ω-6. Studies showed that ω-6 is associated with higher level of proinflammatory cytokines, leading to increased mortality rate, morbidity rate, and postoperative recovery time. The latest generation of emulsion is a mixture of MCT, LCT, olive oil (OO), and fish oil (FO) which may optimize the ω6/ω3 ratio. This study aimed to compare the effect of MCT/LCT/OO/FO IVLE to standard IVLE on IL-1β, IL-8 and plasma fatty acids in infants who had undergone gastrointestinal surgery. Methods: A single-blind, randomised controlled, pretest-posttest design study was done in twelve subjects that were classified into two groups. Group 1 received standard IVLE, group 2 received MCT/LCT/OO/FO IVLE. The type of standard and MCT/LCT/OO/FO IVLE used in this study were Lipofundin 20% and SMOFlipid 20%, respectively, both administered for three consecutive days in 1-4 gram/kilogram/day. IL-1β and IL-8 were examined using ELISA while fatty acids was analyzed using gas chromatography tandem mass spectrometry (GC-MS). Statistical analyses were performed using SPSS for Mac 23. Results: No statistical difference was found in age, gender, birth weight and diagnosis between both groups. Leukocyte was significantly lower in MCT/LCT/OO/FO group 3 days after surgery (p=0.025). CRP was lower in MCT/LCT/OO/FO group 3 days after surgery (p=0.01) and in changes within 3 days (p=0.016). There were no differences in IL-1β, IL-8 and ω-3 but ω-6 was higher in standard IVFE group on third day after surgery (p=0,048) Conclusion: MCT/LCT/OO/FO IVLE can significantly lower leukocyte, CRP and ω-6 levels and is comparable with standard IVLE on IL-1β, IL-8 and ω-3 levels in infants underwent gastrointestinal surgery.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 91%

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Comparison of two lipid emulsions on interleukin-1β, interleukin-8 and fatty acid composition in infants post gastrointestinal surgery: a randomized trial

et al. 2020

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“…ω-3 fatty acids may also act as a regulator of the immune system and mitigator of inflammation since it acts as a precursor for lipid mediator 16 . Our previous study showed lower levels of proinflammatory cytokines IL-6 and TNF-α in subjects who received the mixture of MCT/LCT/OO/FO compared with subjects who received MCT/LCT IVLE 17 . To our knowledge, there been no study regarding the effects of MCT/LCT/OO/FO IVLE on IL-1β and IL-8 levels and fatty acid composition in infants who undergo gastrointestinal surgery, compared to those who receive standard IVLE.…”

Section: Introductionmentioning

confidence: 91%

Comparison of two lipid emulsions on interleukin-1β, interleukin-8 and fatty acid composition in infants post gastrointestinal surgery: a randomized trial

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Nutritional support plays an essential role for recovery in infants who undergo gastrointestinal surgery. The current standard type of intravenous lipid emulsion (IVLE) used as parenteral nutrition is the mixture of medium-chain triglyceride (MCT) and long chain triglyceride (LCT) rich in ω-6. Studies showed that ω-6 is associated with higher level of proinflammatory cytokines, leading to increased mortality rate, morbidity rate, and postoperative recovery time. The latest generation of emulsion is a mixture of MCT, LCT, olive oil (OO), and fish oil (FO) which may optimize the ω6/ω3 ratio. This study aimed to compare the effect of MCT/LCT/OO/FO IVLE to standard IVLE on IL-1β, IL-8 and serum fatty acids in infants who had undergone gastrointestinal surgery. Methods: A single-blind, randomised controlled, pretest-posttest design study was done in twelve subjects that were classified into two groups. Group 1 received standard IVLE, group 2 received MCT/LCT/OO/FO IVLE. The type of standard and MCT/LCT/OO/FO IVLE used in this study were Lipofundin 20% and SMOFlipid 20%, respectively, both administered for three consecutive days in 1-4 gram/kilogram/day. IL-1β and IL-8 were examined using ELISA while fatty acids was analyzed using gas chromatography tandem mass spectrometry (GC-MS). Statistical analyses were performed using SPSS for Mac 23. Results: No statistical difference was found in age, gender, birth weight and diagnosis between both groups. Leukocyte was significantly lower in MCT/LCT/OO/FO group 3 days after surgery (p=0.025). CRP was lower in MCT/LCT/OO/FO group 3 days after surgery (p=0.01) and in changes within 3 days (p=0.016). There were no differences in IL-1β, IL-8 and ω-3 but ω-6 was higher in standard IVFE group on third day after surgery (p=0,048) Conclusion: MCT/LCT/OO/FO IVLE can significantly lower leukocyte, CRP and ω-6 levels and is comparable with standard IVLE on IL-1β, IL-8 and ω-3 levels in infants who had undergone gastrointestinal surgery.

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“…ω-3 may also act as a regulator of the immune system and mitigator of inflammation since it acts as a precursor for lipid mediator 16 . Our previous study showed lower levels of proinflammatory cytokines IL-6 and TNF-α in subjects who received the mixture of MCT/LCT/OO/FO compared with subjects who received MCT/LCT IVLE 17 . To our knowledge, there been no study regarding the effects of MCT/ LCT/OO/FO IVLE on IL-1β and IL-8 levels and fatty acid composition in infants who undergo gastrointestinal surgery, compared to those who receive standard IVLE.…”

Section: Introductionmentioning

confidence: 91%

Comparison of two lipid emulsions on interleukin-1β, interleukin-8 and fatty acid composition in infants post gastrointestinal surgery: a randomized trial

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Nutritional support plays an essential role for recovery in infants who undergo gastrointestinal surgery. The current standard type of intravenous lipid emulsion (IVLE) used as parenteral nutrition is the mixture of medium-chain triglyceride (MCT) and long chain triglyceride (LCT) rich in ω-6. Studies showed that ω-6 is associated with higher level of proinflammatory cytokines, leading to increased mortality rate, morbidity rate, and postoperative recovery time. The latest generation of emulsion is a mixture of MCT, LCT, olive oil (OO), and fish oil (FO) which may optimize the ω6/ω3 ratio. This study aimed to compare the effect of MCT/LCT/OO/FO IVLE to standard IVLE on IL-1β, IL-8 and plasma fatty acid composition in infants who had undergone gastrointestinal surgery. Methods: A single-blind, randomised controlled, pretest-posttest design study was done in twelve subjects that were classified into two groups. Group 1 received standard IVLE, group 2 received MCT/LCT/OO/FO IVLE. The type of standard and MCT/LCT/OO/FO IVLE used in this study were Lipofundin 20% and SMOFlipid 20%, respectively, both administered for three consecutive days in 1-4 gram/kilogram/day. IL-1β and IL-8 were examined using ELISA while fatty acid composition was analyzed using gas chromatography tandem mass spectrometry (GC-MS). Statistical analyses were performed using SPSS for Mac 23. Results: No statistical difference was found in age, gender, birth weight and diagnosis, between both groups. Leukocyte level was significantly lower in MCT/LCT/OO/FO group 3 days after surgery (p=0.025). CRP level was lower in MCT/LCT/OO/FO group 3 days after surgery (p=0.01) and in changes within 3 days (p=0.016). There were no differences in IL-1β and IL-8 but ω-6 was higher in standard IVFE group on third day after surgery (p=0,048). Conclusion: MCT/LCT/OO/FO IVLE can significantly lower leukocyte, CRP and ω-6 levels and is comparable with standard IVLE on IL-1β & IL-8 levels in infants underwent gastrointestinal surgery.

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Influence of Intravenous Fish Oil-Enriched Lipid Emulsion on the Inflammatory Response in Children Post Gastrointestinal Surgery

Cited by 4 publications

References 26 publications

Comparison of two lipid emulsions on interleukin-1β, interleukin-8 and fatty acid composition in infants post gastrointestinal surgery: a randomized trial

Comparison of two lipid emulsions on interleukin-1β, interleukin-8 and fatty acid composition in infants post gastrointestinal surgery: a randomized trial

Comparison of two lipid emulsions on interleukin-1β, interleukin-8 and fatty acid composition in infants post gastrointestinal surgery: a randomized trial

Comparison of two lipid emulsions on interleukin-1β, interleukin-8 and fatty acid composition in infants post gastrointestinal surgery: a randomized trial

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