Influence of ion-pairing and chemical enhancers on the transdermal delivery of meloxicam

Zhang, Jingying; Fang, Liang; Tan, Zhe; Wu, Jing; Zhang, He

doi:10.1080/03639040802578111

Cited by 15 publications

(5 citation statements)

References 19 publications

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“…Moreover, low frequency ultrasound has stronger penetration promotion effect than high frequency ultrasound, and its penetration promotion effect is better than high frequency ultrasound. The thermal shock, cavitation shock and flow shock caused by it may be related to this law [14][15][16][17]. It was found in this study that the efficacy of patients in the observation group was more significant than that in the control group in all aspects and dimensions, such as total effective rate, VAS score, and degree of mass dissipation, and no obvious side effects or adverse reactions occurred in patients in both groups, such as skin allergic rash, skin flushing and even ulceration.…”

Section: Discussionmentioning

confidence: 99%

Clinical Observation of Ruyi Jinhuang Powder Combined with Ultrasonic Iontophotosis in the Treatment of Multiple Stye

2023

medcm

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In order to observe the clinical efficacy of Ruyi Jinhuang Powder combined with ultrasonic iontophotosis in the treatment of multiple stele, 90 patients with multiple stele treated in the ophthalmology department of our hospital from January to June 2023 were randomly divided into the observation group and the control group, 45 cases in each group. The control group was treated with ofloxacin eye ointment, and the observation group was treated with Ruyi Jinhuang Powder combined with ultrasonic iontophoresis on the basis of the control group. The treatment cycle of both groups was 7 days. The clinical efficacy, visual analogue score (VAS) and the changes of tumor size were compared between the two groups to observe and compare the clinical efficacy. And pay attention to the side effects and adverse reactions of patients in the course of treatment. By observing and studying the therapeutic effect of all patients, we found that the total effective rate of the observation group was 88.89%, which was significantly higher than that of the control group (80.00%). After systemic treatment, the visual analogue scale (VAS) scores of both groups decreased significantly, but the decrease was greater in the observation group. In addition, the size of the mass after treatment was compared with that before treatment, and the intra-group comparison: both groups were smaller than that before treatment, the difference was statistically significant. Therefore, we have reached the following conclusion: the combination of Ruyi Jinhuang Powder and ultrasonic iontophoresis in the treatment of multiple stes can effectively help patients relieve pain and promote the elimination of eyelid sclerosis.

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Section: Discussionmentioning

confidence: 99%

Clinical Observation of Ruyi Jinhuang Powder Combined with Ultrasonic Iontophotosis in the Treatment of Multiple Stye

2023

medcm

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“…[4] In another experiment the researcher investigated the effect of ion pairing on meloxicam, with six organic bases and four normal permeation enhancers, which include oleic acid, menthol, azone, and N-methyl-2-pyrrolidone. [5] The cumulative permeation is markedly increased in the presence of either a counter ion or chemical enhancers, and the results clearly suggest that the degree of enhancement depends only on the structure and hydrophilicity of the counter ions. However, overall only the limited permeation enhancement ratio is achieved with ion pairing techniques.…”

Section: Ph Regulationmentioning

confidence: 92%

Percutaneous penetration enhancement in transdermal drug delivery

Singh¹,

Sri²

2010

Asian J Pharm

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T he transdermal route has numerous advantages over the more traditional drug delivery routes. These include high bioavailability, absence of first pass hepatic metabolism, steady drug plasma concentrations, and the fact that therapy is non-invasive. The main obstacle to permeating drug molecules is the outermost layer of the skin, the stratum corneum. Consequently, research into enhancing transdermal drug delivery (TDD) by overcoming this layer, is an area of prime interest. This review article is written to provide a coverage commentary of the recent advancements in TDD enhancement techniques.

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“…Chemical enhancer Sodium salicylate (Hadgraft et al, 1985;Smith & Irwin, 2000); Sodium naproxen (Escobar-Chavez et al, 2005); Ibuprofen (Philips & Michniak,1995;Shen et al, 2007); Nonivamide acetate (Fang et al, 1997); Meloxicam (Zhang et al, 2009); Flurbiprofen (Ma et al, 2010); Naloxone (Xu et al, 2007); Furosemide (Agyralides et al, 2004); Methotrexate (Allan, 1995); Sumatriptan succinate (Balaguer-Fernandez et al, 2010).…”

Section: Drugmentioning

confidence: 99%

Chemical and Physical Enhancers for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

2012

Pharmacology

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Influence of ion-pairing and chemical enhancers on the transdermal delivery of meloxicam

Abstract: The cumulative permeation was markedly increased in the presence of either a counter ion or chemical enhancers. These results suggest that the degree of enhancement possibly depends on the structure and hydrophilicity of the counter ions.

Cited by 15 publications

References 19 publications

Clinical Observation of Ruyi Jinhuang Powder Combined with Ultrasonic Iontophotosis in the Treatment of Multiple Stye

Clinical Observation of Ruyi Jinhuang Powder Combined with Ultrasonic Iontophotosis in the Treatment of Multiple Stye

Percutaneous penetration enhancement in transdermal drug delivery

Chemical and Physical Enhancers for Transdermal Drug Delivery

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