Influence of Iontophoresis on Delivery of NSAID-loaded Deformable Liposomal Dispersions:
            <i>In Vitro</i>
            and
            <i>In Vivo</i>
            Evaluation

Kenchappa, Vanaja; Salwa, Slawomir; Shivakumar, H.N.; Murthy, S. N. B.

doi:10.4155/tde-2023-0005

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…At present, there are many methods to prepare liposomes [ 19 , [25] , [26] , [27] , [28] , [29] ], including film dispersion method, ultrasonic dispersion method, injection method, freeze-drying method, freeze-thaw method and reverse phase evaporation method. The liposomes prepared by these methods were not uniform in size and poor in stability.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics study of ginsenoside Rg1 liposome by pulmonary administration

Liang,

Zhang,

Hou

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics study of ginsenoside Rg1 liposome by pulmonary administration

Liang,

Zhang,

Hou

et al. 2024

Heliyon

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Hypothesizing the Oleic Acid-Mediated Enhanced and Sustained Transdermal Codelivery of Pregabalin and Diclofenac Adhesive Nanogel: A Proof of Concept

Datta,

Noor,

Rathee

et al. 2024

CMM

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Pregabalin (PG) and diclofenac diethylamine (DEE) are anti-inflammatory molecules that are effective in relieving inflammation and pain associated with musculoskeletal disorders, arthritis, and post-traumatic pain, among others. Intravenous and oral delivery of these two molecules has their limitations. However, the transdermal route is believed to be an alternate viable option for the delivery of therapeutic molecules with desired physicochemical properties. To this end, it is vital to understand the physicochemical properties of these drugs, dosage, and strategies to enhance permeation, thereby surmounting the associated constraints and concurrently attaining a sustained release of these therapeutic molecules when administered in combination. The present work hypothesizes the enhanced permeation and sustained release of pregabalin and diclofenac diethylamine across the skin, entrapped in the adhesive nano-organogel formulation, including permeation enhancers. The solubility studies of pregabalin and diclofenac diethylamine in combination were performed in different permeation enhancers. Oleic acid was optimized as the best permeation enhancer based on in vitro studies. Pluronic organogel containing pregabalin and diclofenac diethylamine with oleic acid was fabricated. Duro-Tak® (87-2196) was added to the organogel formulation as a pressure-sensitive adhesive to sustain the release profile of these two therapeutic molecules. The adhesive organogel was characterized for particle size, scanning electron microscopy, and contact angle measurement. The HPLC method developed for the quantification of the dual drug showed a retention time of 3.84 minutes and 9.69 minutes for pregabalin and diclofenac, respectively. The fabricated nanogel adhesive formulation showed the desired results with particle size and contact angle of 282 ± 57 nm and ≥120⁰, respectively. In vitro studies showed the percentage cumulative release of 24.90 ± 4.65% and 33.29 ± 4.81% for pregabalin and diclofenac, respectively. In order to accomplish transdermal permeation, the suggested hypothesis of fabricating PG and DEE nano-organogel in combination with permeation enhancers will be a viable drug delivery method. In comparison to a traditional gel formulation, oleic acid as a permeation enhancer increased the penetration of both PG and DEE from the organogel formulation. Notably, the studies showed that the use of pressure-sensitive adhesives enabled the sustained release of both PG and DEE.Therefore, the results anticipated the hypothesis that the transdermal delivery of adhesive PG and DEEbased nanogel across the human skin can be achieved to inhibit inflammation and pain.

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Influence of Iontophoresis on Delivery of NSAID-loaded Deformable Liposomal Dispersions: In Vitro and In Vivo Evaluation

Cited by 2 publications

References 57 publications

Pharmacokinetics study of ginsenoside Rg1 liposome by pulmonary administration

Pharmacokinetics study of ginsenoside Rg1 liposome by pulmonary administration

Hypothesizing the Oleic Acid-Mediated Enhanced and Sustained Transdermal Codelivery of Pregabalin and Diclofenac Adhesive Nanogel: A Proof of Concept

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