Influence of Iron Alone or with Fluoride on Caries Development in Desalivated and Intact Rats

Miguel, Joao C.; Bowen, William H.; Pearson, S.K.

doi:10.1159/000262407

Cited by 27 publications

(14 citation statements)

References 5 publications

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“…Contrarily to previous studies reporting a cariostatic effect of Fe [4,11], the findings of the present study did not confirm the negative correlation between caries prevalence and increased Fe concentration in drinking water. One possible explanation of these findings is that when groundwater is pumped up to the surface, soluble Fe 2? compounds contact air and transform into the insoluble Fe 3?…”

Section: Discussioncontrasting

confidence: 99%

Caries prevalence and manganese and iron levels of drinking water in school children living in a rural/semi-urban region of North-Eastern Greece

Tsanidou

Nena

Rossos

et al. 2015

Environ Health Prev Med

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Objective The aim of this study was to correlate different combinations of manganese (Mn) and iron (Fe) concentration in drinking water with prevalence of dental caries in both primary and permanent dentition, among school children with similar socio-demographic characteristics. Methods Evros region, in North-Eastern Greece, was divided into four areas, according to combinations of levels of Mn and Fe in drinking water (High Mn-high Fe; High Mn-low Fe; Low Mn-high Fe; Low Mn-low Fe). Children of similar socio-economic background, attending either first or sixth grade (primary or permanent dentition, respectively) of elementary schools, were clinically assessed for caries by three dentists. Caries was defined by the use of dmft/DMFT index. A questionnaire answered by the parents was also analysed. Results 573 children were included. Caries prevalence was high in both age groups (64.2 % with mean dmft 3.3 ± 3.6 in primary and 60.7 % with mean DMFT 2.3 ± 2.5 in permanent dentition, respectively). Residence in a high Mn-low Fe area was associated with a significant OR for caries in both age groups [OR (95 % CIs) for primary and permanent dentition was, respectively, 3.75 (1.68-8.37), p = 0.001 and 3.09 (1.48-6.44), p = 0.003], independently of factors like sugar consumption or brushing frequency. Conclusion Prevalence of caries was high in general, and was associated with the combination of high Mn/low Fe levels in drinking water, independently of various sociodemographic factors.

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Section: Discussioncontrasting

confidence: 99%

Caries prevalence and manganese and iron levels of drinking water in school children living in a rural/semi-urban region of North-Eastern Greece

Tsanidou

Nena

Rossos

et al. 2015

Environ Health Prev Med

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“…The use of 20% sucrose was based on results of mineral loss found in previous studies [Cury et al, 1997[Cury et al, , 2000, and the concentrations of Fe were chosen on the basis of results of caries reduction in rats [Miguel et al, 1997c] and data from a pilot study previously carried out in situ.…”

Section: Treatmentsmentioning

confidence: 99%

Effect of Sucrose Containing Iron (II) on Dental Biofilm and Enamel Demineralization in situ

et al. 2005

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Since the effect of iron (Fe) on the cariogenicity of sucrose in humans is unexplored, this study assessed in situ the effect of Fe co-crystallized with sucrose (Fe-sucrose) topically applied in vitro on the acidogenicity, biochemical and microbiological composition of the dental biofilm formed in vivo and on the demineralization of the enamel. During two phases of 14 days each, 16 volunteers wore palatal appliances containing blocks of human enamel, which were submitted to four groups of separate treatments: (1) water; (2) 20% sucrose; (3) 20% (w/v) sucrose plus 18 µg Fe/ml, and (4) 20% (w/v) sucrose plus 70 µg Fe/ml. The solutions were dripped onto the blocks 8 times per day. The biofilms formed on the blocks were analyzed with respect to acidogenicity, biochemical and microbiological composition. Mineral loss was determined on enamel by surface and cross-sectional microhardness. Lower demineralization was found in the blocks subjected to Fe-sucrose (70 µg Fe/ml) than in those treated with sucrose (p < 0.05). This concentration of Fe also reduced significantly the populations of mutans streptococci in the biofilm formed on the blocks. In conclusion, our data suggest that Fe may reduce in situ the cariogenic potential of sucrose and the effect seems to be related to the reduction in the populations of mutans streptococci in the dental biofilm formed.

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“…Findings from previous studies are contradictory, with reports of no relationship [10], a weak relationship [9] and even a direct relationship between micronutrient deficiencies and dental caries [7,11,13]. However, studies that have related malnutrition or micronutrient deficiencies to dental caries in the primary dentition offer indirect evidence of this association [19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…It is possible that micronutrients are protective elements against the occurrence of dental caries by contributing to the formation of tooth enamel or by protecting the enamel from bacterial effects [7,26,27]. This effect is plausible, since micronutrient intake at 12 months of age may reflect intake in the previous months, when the primary molars are undergoing the process of calcification.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, divergent opinions are found on the association between micronutrient intake and early childhood caries. While some studies have found no such association, others suggest that micronutrients have a cariostatic effect and others suggest a cariogenic effect [6][7][8][9][10][11][12][13]. However, the majority of these findings come from animal studies or investigations involving human subjects using a cross-sectional design.…”

Section: Introductionmentioning

confidence: 99%

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No Impact of Lower Intake of Micronutrients on Severe Early Childhood Caries: Findings from a Prospective Cohort Study

Feldens¹,

Kramer²,

Cascaes³

et al. 2015

Pesqui. bras. odontopediatria clín. integr.

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Objective: To investigate the association between micronutrients intake at 12 months of age and the occurrence of severe early childhood caries (S-ECC) at four years of age among children in southern Brazil. Material and Methods: The baseline sample was made up of 500 mother-child pairs followed since the birth of the child in São Leopoldo, Brazil. After the first birthday, micronutrients intake (calcium, iron, sodium, zinc, vitamin A, vitamin C, vitamin B12 and folate) was recorded using the 24-hour recall method. At four years of age, a calibrated examiner evaluated the occurrence of S-ECC based on internationally accepted criteria. Poisson regression was used to investigate associations between exposures and the outcome. Results: The final sample comprised 314 children. The occurrence of S-ECC was higher among children who consumed less calcium (p=0.009), zinc (p=0.021) and vitamin C (p=0.036). However, after the multivariable adjustments, no micronutrient was associated with the occurrence of S-ECC. Conclusion: A lower intake of micronutrients at 12 months of age did not represent a risk factor for the occurrence of S-ECC at four years of age, suggesting that advice on feeding practices for dental caries prevention should focus mainly on dietary aspects (local effect) rather than nutritional aspects (systemic effect).

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Influence of Iron Alone or with Fluoride on Caries Development in Desalivated and Intact Rats

Cited by 27 publications

References 5 publications

Caries prevalence and manganese and iron levels of drinking water in school children living in a rural/semi-urban region of North-Eastern Greece

Caries prevalence and manganese and iron levels of drinking water in school children living in a rural/semi-urban region of North-Eastern Greece

Effect of Sucrose Containing Iron (II) on Dental Biofilm and Enamel Demineralization in situ

No Impact of Lower Intake of Micronutrients on Severe Early Childhood Caries: Findings from a Prospective Cohort Study

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