Influence of iron supplementation on fatigue, mood states and sweating profiles of healthy non-anemic athletes during a training exercise: A double-blind, randomized, placebo-controlled, parallel-group study

Kapoor, Mahendra P.; Sugita, Masaaki; Kawaguchi, Mikiko; Timm, David H; Kawamura, Aki; Abe, Aya; Ōkubo, Tsutomu

doi:10.1016/j.conctc.2023.101084

Cited by 11 publications

(5 citation statements)

References 87 publications

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“…In particular, it was discovered that serum-iron-deficient participants could have salivary iron even higher than that of the controls . Moreover, an increase in blood iron levels owing to the action of the enzyme lactoferrin follows a drop in saliva iron as a result of physical, mental, or emotional stress. , Thus, the significant decrease in salivary iron in healthy volunteers could be associated with the mobilization of iron stores to boost their blood levels and refill their resources depleted by the load, which results in the successful restoration of the participant’s psychological well-being.…”

Section: Discussionmentioning

confidence: 99%

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

Portnova,

Khayrullina,

Mikheev

et al. 2024

ACS Chem. Neurosci.

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The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time. In this study, we tested the dynamics of behavioral parameters, resting-state electroencephalogram (EEG), and salivary iron, copper, manganese, magnesium, and zinc in 30 healthy volunteers and 30 individuals with OCD before and after an emotional antisaccade task. The eye-movement data served as a measure of behavioral performance. Our research revealed consistently higher manganese concentrations in the OCD group compared to healthy volunteers associated with a higher EEG ratio of amplitude transformation and symptom severity. The dynamics of salivary microelements and resting-state EEG, possibly influenced by cognitive and emotional load during the anticsaccade task, differed between groups. In healthy volunteers, there was a decrease in salivary iron level with an increase in high-frequency power spectral density of EEG. The OCD group showed a decrease in salivary copper with an increased Hjorth mobility of EEG.

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Section: Discussionmentioning

confidence: 99%

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

Portnova,

Khayrullina,

Mikheev

et al. 2024

ACS Chem. Neurosci.

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“…Supplementation with low iron doses was shown to increase cortisol levels in female athletes (Kapoor et al, 2023), but the serum concentration of human placental lactogen was not altered after iron supplementation (Milman et al, 1991). No studies were identified on the effect of iron supplementation and circulating concentrations of lactin, prolactin, and progesterone in pregnant females.…”

Section: Iron Intake and Gestational Diabetes Mellitusmentioning

confidence: 99%

“…In this context, although being healthy, pregnancy was considered as a condition that affects cF, so that the studies included do not comprise pregnant women. The acronym cF includes all measurements where ferritin has been measured either in serum (abbreviated as s-ferritin in the High-Level Protocol), which was done in most of the studies, or in plasma (Kang et al, 2004;Kiss et al, 2015). To achieve an overview of the mentioned dose-response relationship, the effect of variables potentially affecting cF is provided in a descriptive part in the form of exploratory plots.…”

Section: Meta-analyses and Dose-response Relationship Between S-ferri...mentioning

confidence: 99%

Preparatory work for the update of the tolerable upper intake levels for iron

Parlesak,

Masino,

Reis

et al. 2024

EFSA Supporting Publications

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The present document has been produced and adopted by the bodies identified above as authors. This task has been carried out exclusively by the authors in the context of a contract between the European Food Safety Authority and the authors, awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors.

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“…Significant prior work has reported the benefits of oral supplementation in iron compromised athletes, with recent research confirming that 4 weeks of low dose (3.6 mg/day) iron supplementation (Ferric pyrophosphate form of iron, delivering 8% elemental iron) was beneficial for improving endurance athletes' stress, mood states, and subjective fatigue [10]. However, it appears that the timing of iron intake, with consideration for the proximity of exercise, could be important for maximizing iron uptake from any given meal.…”

Section: Iron Intake/supplementation Strategies For Athletesmentioning

confidence: 99%

Iron regulation and absorption in athletes: contemporary thinking and recommendations

Peeling

McKay

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review This review examines recent developments in our understanding of iron regulation/absorption around exercise, with specific attention paid towards the female athlete. Recent findings Building on the well accepted knowledge that hepcidin concentrations increase in the 3–6 h period following an acute bout of exercise, recent studies have shown that this links to a reduced fractional iron absorption from the gut during feedings provided 2 h postexercise. Further, a window of enhanced iron absorption has recently been identified to occur 30 min either side of exercise commencement/completion, which allows for strategic iron intake to optimize absorption around exercise. Finally, there is burgeoning evidence to show that iron status and iron regulation change throughout the menstrual cycle and with hormonal contraceptive use, which could have implications for iron status in female athletes. Summary Exercise can affect iron regulatory hormone activity, which subsequently impairs iron absorption, potentially contributing to the high rates of iron deficiency seen in athletes. Future research should continue to examine strategies to optimize iron absorption, with consideration to the timing, mode and intensity of exercise, the time of day, and in females, the menstrual cycle/menstrual status.

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Influence of iron supplementation on fatigue, mood states and sweating profiles of healthy non-anemic athletes during a training exercise: A double-blind, randomized, placebo-controlled, parallel-group study

Cited by 11 publications

References 87 publications

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

Preparatory work for the update of the tolerable upper intake levels for iron

Iron regulation and absorption in athletes: contemporary thinking and recommendations

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