Influence of ischemic injury on vein graft remodeling: Role of cyclic adenosine monophosphate second messenger pathway in enhanced vein graft preservation

Sakaguchi, Taichi; Asai, Tomohiro; Белов, Д. В.; Okada, Morihito; Pinsky, David J.; Schmidt, Ann Marie; Naka, Yoshifumi

doi:10.1016/j.jtcvs.2004.04.014

Cited by 17 publications

(9 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[133, 134] In general however, monocytes and polymorphonuclear cells (PMN) can bind to the vein graft in high shear conditions (20-40 dynes/cm 2 ) through the leukocyte β 2 -integrins, α M β 2 (MAC-1) and α L β 2 (LFA-1) receptors allowing firm adhesion to vascular cells and more than 30 proteins of the extracellular matrix including fibrinogen. [135, 136] Early induction of MMPs to breakdown BM and other ECM barriers not only permits SMC migration out toward the intima, but also facilitates PMNs and monocyte entry into the vessel wall.…”

Section: Inflammatory Cell Phenotype and The Fate Of Remodelingmentioning

confidence: 99%

Vein graft failure

Owens

Gasper

Rahman

et al. 2015

Journal of Vascular Surgery

123

107

View full text Add to dashboard Cite

Following the creation of an autogenous lower extremity bypass graft, the vein must undergo a series of dynamic structural changes to stabilize the arterial hemodynamic forces. These changes, commonly referred to as remodeling, include an inflammatory response, the development of a neointima, matrix turnover, and cellular proliferation and apoptosis. The sum total of these processes results in dramatic alterations in the physical and biomechanical attributes of the arterialized vein. The most clinically obvious and easily measured of these is lumen remodeling of the graft. However, though somewhat less precise, wall thickness, matrix composition, and endothelial changes can be measured in vivo within the healing vein graft. Recent translational work has demonstrated the clinical relevance of remodeling as it relates to vein graft patency and the systemic factors influencing it. By correlating histologic and molecular changes in the vein, insights into potential therapeutic strategies to prevent bypass failure and areas for future investigation are explored.

show abstract

Section: Inflammatory Cell Phenotype and The Fate Of Remodelingmentioning

confidence: 99%

Vein graft failure

Owens

Gasper

Rahman

et al. 2015

Journal of Vascular Surgery

123

107

View full text Add to dashboard Cite

show abstract

“…From the reported representative images, this model could induce obvious neointimal formation and wall thickening (day 20). Sakaguchi and associates 13 have reported an application of this technique to create a model that used a jugular patch to repair an abdominal aorta defect.…”

Section: Mouse Vein Bypass Graft Modelsmentioning

confidence: 99%

Rationale and practical techniques for mouse models of early vein graft adaptations

Nguyen

Tao

et al. 2010

Journal of Vascular Surgery

View full text Add to dashboard Cite

Mouse models serve as relatively new yet powerful research tools to study intimal hyperplasia and wall remodeling of vein bypass graft failure. Several model variations have been reported in the past decade. However, the approach demands thoughtful preparation, selected sophisticated equipment, microsurgical technical expertise, advanced tissue processing and data acquisition. This review compares several described models, and aims (building on our personal experiences) to practically aid the investigators who want to utilize mouse models of vein graft failure.

show abstract

“…In an animal model Sakaguchi et al could demonstrate an increased neointimal area in veins stored for 2 h before grafting compared with immediately grafted veins. Furthermore the increased storage time was associated with a decreased cAMP amount in the veins [7].…”

Section: Surgical Handling Of Svgsmentioning

confidence: 91%